Intermediate cleaving peptidase 55 explained

Intermediate cleaving peptidase 55
Ec Number:	3.4.11.26

Intermediate cleaving peptidase 55 (Icp55, mitochondrial intermediate cleaving peptidase 55 kDa) is an enzyme.^{[1] [2]} This enzyme catalyses the following chemical reaction

The enzyme cleaves the Pro36-Pro37 bond of cysteine desulfurase (EC 2.8.1.7) removing three amino acid residues (Tyr-Ser-Pro) from the N-terminus after cleavage by mitochondrial processing peptidase.

Icp55 removes the destabilizing N-terminal amino acid residues.

Notes and References

1. Naamati A, Regev-Rudzki N, Galperin S, Lill R, Pines O . Dual targeting of Nfs1 and discovery of its novel processing enzyme, Icp55 . The Journal of Biological Chemistry . 284 . 44 . 30200–8 . October 2009 . 19720832 . 2781575 . 10.1074/jbc.M109.034694 . free .
2. Vögtle FN, Wortelkamp S, Zahedi RP, Becker D, Leidhold C, Gevaert K, Kellermann J, Voos W, Sickmann A, Pfanner N, Meisinger C . Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability . Cell . 139 . 2 . 428–39 . October 2009 . 19837041 . 10.1016/j.cell.2009.07.045 . 12789215 . free .