Interleukin receptor explained

Interleukin receptors are a family of cytokine receptors for interleukins. They belong to the immunoglobulin superfamily.

Types

There are two main families of Interleukin receptors, Type 1 and Type 2.

Type 1

Type 1 interleukin receptors include:^{[1] [2]}

• Interleukin-1 receptor
• Interleukin-2 receptor
• Interleukin-3 receptor
• Interleukin-4 receptor
• Interleukin-5 receptor
• Interleukin-6 receptor
• Interleukin-7 receptor
• Interleukin-9 receptor
• Interleukin-11 receptor
• Interleukin-12 receptor
• Interleukin-13 receptor
• Interleukin-15 receptor
• Interleukin-18 receptor
• Interleukin-21 receptor
• Interleukin-23 receptor
• Interleukin-27 receptor

Type 2

Type 2 interleukin receptors are Type II cytokine receptors. They include:^[3]

• Interleukin-10 receptor
• Interleukin-20 receptor
• Interleukin-22 receptor
• Interleukin-28 receptor

Other

• Interleukin-8 receptor, RANTES receptors (CCR1, CCR3, CCR5), MIP-1 receptor, PF4 receptor, M-CSF receptor and NAP-2 receptor belong to GPCR chemokine receptor family.

Notes and References

1. Subramaniam S, Stansberg C, Cunningham C . The interleukin 1 receptor family . Dev. Comp. Immunol. . 28 . 5 . 415–28 . May 2004 . 15062641 . 10.1016/j.dci.2003.09.016 .
2. Boraschi D, Tagliabue A . The interleukin-1 receptor family . Vitam. Horm. . Vitamins & Hormones . 74 . 229–54 . 2006 . 17027517 . 10.1016/S0083-6729(06)74009-2 . 9780127098746 .
3. Donnelly RP, Sheikh F, Kotenko SV, Dickensheets H . The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain . J. Leukoc. Biol. . 76 . 2 . 314–21 . August 2004 . 15123776 . 10.1189/jlb.0204117 . free .