See also: Interleukin-1 receptor family.
| interleukin 1 receptor, type I | |
| Hgncid: | 5993 |
| Symbol: | IL1R1 |
| Altsymbols: | IL1R, IL1RA |
| Entrezgene: | 3554 |
| Omim: | 147810 |
| Refseq: | NM_000877 |
| Uniprot: | P14778 |
| Chromosome: | 2 |
| Arm: | q |
| Band: | 12 |
| interleukin 1 receptor, type II | |
| Hgncid: | 5994 |
| Symbol: | IL1R2 |
| Altsymbols: | IL1RB |
| Entrezgene: | 7850 |
| Omim: | 147811 |
| Refseq: | NM_173343 |
| Uniprot: | P27930 |
| Chromosome: | 2 |
| Arm: | q |
| Band: | 12 |
| interleukin 1 receptor accessory protein | |
| Hgncid: | 5995 |
| Symbol: | IL1RAP |
| Altsymbols: | IL-1RAcP, IL1R3, C3orf13 |
| Entrezgene: | 3556 |
| Omim: | 602626 |
| Refseq: | NM_134470 |
| Uniprot: | Q9NPH3 |
| Chromosome: | 3 |
| Arm: | q |
| Band: | 28 |
Interleukin-1 receptor (IL-1R) is a cytokine receptor which binds interleukin 1.[1] Two forms of the receptor exist. The type I receptor is primarily responsible for transmitting the inflammatory effects of interleukin-1 (IL-1) while type II receptors may act as a suppressor of IL-1 activity by competing for IL-1 binding.[1] Also opposing the effects of IL-1 is the IL-1 receptor antagonist (IL-1RA).[2]
The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction.[3]