Interleukin 11 receptor alpha subunit explained

Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. IL11RA is its human gene.^[1]

Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus and two variants, each encoding a distinct isoform, have been identified.^[2]

Further reading

• Chérel M, Sorel M, Lebeau B, etal . Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11 . Blood . 86 . 7 . 2534–40 . 1995 . 7670098 . 10.1182/blood.V86.7.2534.bloodjournal8672534. 2024-05-13 . free .
• Chérel M, Sorel M, Apiou F, etal . The human interleukin-11 receptor alpha gene (IL11RA): genomic organization and chromosome mapping . Genomics . 32 . 1 . 49–53 . 1996 . 8786120 . 10.1006/geno.1996.0075 .
• Van Leuven F, Stas L, Hilliker C, etal . Molecular cloning and characterization of the human interleukin-11 receptor alpha-chain gene, IL11RA, located on chromosome 9p13 . Genomics . 31 . 1 . 65–70 . 1996 . 8808281 . 10.1006/geno.1996.0010 .
• Magrangeas F, Pitiot G, Dubois S, etal . Cotranscription and intergenic splicing of human galactose-1-phosphate uridylyltransferase and interleukin-11 receptor alpha-chain genes generate a fusion mRNA in normal cells. Implication for the production of multidomain proteins during evolution . J. Biol. Chem. . 273 . 26 . 16005–10 . 1998 . 9632650 . 10.1074/jbc.273.26.16005 . free .
• Barton VA, Hudson KR, Heath JK . Identification of three distinct receptor binding sites of murine interleukin-11 . J. Biol. Chem. . 274 . 9 . 5755–61 . 1999 . 10026196 . 10.1074/jbc.274.9.5755 . free .
• Tacken I, Dahmen H, Boisteau O, etal . Definition of receptor binding sites on human interleukin-11 by molecular modeling-guided mutagenesis . Eur. J. Biochem. . 265 . 2 . 645–55 . 1999 . 10504396 . 10.1046/j.1432-1327.1999.00755.x . free .
• Campbell CL, Jiang Z, Savarese DM, Savarese TM . Increased expression of the interleukin-11 receptor and evidence of STAT3 activation in prostate carcinoma . Am. J. Pathol. . 158 . 1 . 25–32 . 2001 . 11141475 . 10.1016/S0002-9440(10)63940-5. 1850253 .
• Cork BA, Tuckerman EM, Li TC, Laird SM . Expression of interleukin (IL)-11 receptor by the human endometrium in vivo and effects of IL-11, IL-6 and LIF on the production of MMP and cytokines by human endometrial cells in vitro . Mol. Hum. Reprod. . 8 . 9 . 841–8 . 2003 . 12200462 . 10.1093/molehr/8.9.841 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Karpovich N, Chobotova K, Carver J, etal . Expression and function of interleukin-11 and its receptor alpha in the human endometrium . Mol. Hum. Reprod. . 9 . 2 . 75–80 . 2003 . 12569176 . 10.1093/molehr/gag012 . 1626582 .
• Kiessling S, Muller-Newen G, Leeb SN, etal . Functional expression of the interleukin-11 receptor alpha-chain and evidence of antiapoptotic effects in human colonic epithelial cells . J. Biol. Chem. . 279 . 11 . 10304–15 . 2004 . 14701802 . 10.1074/jbc.M312757200 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Zurita AJ, Troncoso P, Cardó-Vila M, etal . Combinatorial screenings in patients: the interleukin-11 receptor alpha as a candidate target in the progression of human prostate cancer . Cancer Res. . 64 . 2 . 435–9 . 2004 . 14744752 . 10.1158/0008-5472.CAN-03-2675 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Tsimanis A, Shtalrid M, Shvidel L, etal . Expression of interleukin-11 receptor in CD38-positive cells from patients with multiple myeloma . Leuk. Lymphoma . 45 . 11 . 2315–9 . 2005 . 15512823 . 10.1080/10428190412331283161 . 27011485 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Karube K, Ohshima K, Suzumiya J, etal . Gene expression profile of cytokines and chemokines in microdissected primary Hodgkin and Reed-Sternberg (HRS) cells: high expression of interleukin-11 receptor alpha . Ann. Oncol. . 17 . 1 . 110–6 . 2006 . 16291580 . 10.1093/annonc/mdj064 . free .
• Hanavadi S, Martin TA, Watkins G, etal . Expression of interleukin 11 and its receptor and their prognostic value in human breast cancer . Ann. Surg. Oncol. . 13 . 6 . 802–8 . 2006 . 16614887 . 10.1245/ASO.2006.05.028 . 5693500 .
• Yoshizaki A, Nakayama T, Yamazumi K, etal . Expression of interleukin (IL)-11 and IL-11 receptor in human colorectal adenocarcinoma: IL-11 up-regulation of the invasive and proliferative activity of human colorectal carcinoma cells . Int. J. Oncol. . 29 . 4 . 869–76 . 2006 . 16964382 . 10.3892/ijo.29.4.869. free .
• Nakayama T, Yoshizaki A, Izumida S, etal . Expression of interleukin-11 (IL-11) and IL-11 receptor alpha in human gastric carcinoma and IL-11 upregulates the invasive activity of human gastric carcinoma cells . Int. J. Oncol. . 30 . 4 . 825–33 . 2007 . 17332920 . 10.3892/ijo.30.4.825. free .

Notes and References

1. Web site: Entrez Gene: IL11RA interleukin 11 receptor, alpha.
2. Web site: Entrez Gene: IL11RA interleukin 11 receptor, alpha.