Interleukin 10 receptor, beta subunit explained

Interleukin 10 receptor, beta subunit is a subunit for the interleukin-10 receptor. IL10RB is its human gene.^[1]

IL10RB has also been designated CDw210b (cluster of differentiation w210b).

The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFNAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21.^[2]

Further reading

• Lutfalla G, McInnis MG, Antonarakis SE, Uzé G . Structure of the human CRFB4 gene: comparison with its IFNAR neighbor. . J. Mol. Evol. . 41 . 3 . 338–44 . 1995 . 7563119 . 10.1007/BF01215180 . 38574595 .
• Lutfalla G, Gardiner K, Uzé G . A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR. . Genomics . 16 . 2 . 366–73 . 1993 . 8314576 . 10.1006/geno.1993.1199 .
• Gibbs VC, Pennica D . CRF2-4: isolation of cDNA clones encoding the human and mouse proteins. . Gene . 186 . 1 . 97–101 . 1997 . 9047351 . 10.1016/S0378-1119(96)00690-7 .
• Kotenko SV, Krause CD, Izotova LS, etal . Identification and functional characterization of a second chain of the interleukin-10 receptor complex. . EMBO J. . 16 . 19 . 5894–903 . 1997 . 9312047 . 10.1093/emboj/16.19.5894 . 1170220 .
• Spencer SD, Di Marco F, Hooley J, etal . The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor. . J. Exp. Med. . 187 . 4 . 571–8 . 1998 . 9463407 . 10.1084/jem.187.4.571 . 2212143 .
• Reboul J, Gardiner K, Monneron D, etal . Comparative genomic analysis of the interferon/interleukin-10 receptor gene cluster. . Genome Res. . 9 . 3 . 242–50 . 1999 . 10077530 . 10.1101/gr.9.3.242. 310731 .
• Hattori M, Fujiyama A, Taylor TD, etal . The DNA sequence of human chromosome 21. . Nature . 405 . 6784 . 311–9 . 2000 . 10830953 . 10.1038/35012518 . 2000Natur.405..311H . free .
• Xie MH, Aggarwal S, Ho WH, etal . Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. . J. Biol. Chem. . 275 . 40 . 31335–9 . 2000 . 10875937 . 10.1074/jbc.M005304200 . free .
• Dumoutier L, Van Roost E, Colau D, Renauld JC . Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor. . Proc. Natl. Acad. Sci. U.S.A. . 97 . 18 . 10144–9 . 2000 . 10954742 . 10.1073/pnas.170291697 . 27764 . 2000PNAS...9710144D . free .
• Lewis K, Li C, Perrin MH, etal . Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. . Proc. Natl. Acad. Sci. U.S.A. . 98 . 13 . 7570–5 . 2001 . 11416224 . 10.1073/pnas.121165198 . 34709 . 2001PNAS...98.7570L . free .
• Hollborn M, Kohen L, Wiedemann P, Enzmann V . The influence of pro-inflammatory cytokines on human retinal pigment epithelium cell receptors. . Graefes Arch. Clin. Exp. Ophthalmol. . 239 . 4 . 294–301 . 2001 . 11450494 . 10.1007/s004170100263 . 676836 .
• Josephson K, Logsdon NJ, Walter MR . Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site. . Immunity . 15 . 1 . 35–46 . 2001 . 11485736 . 10.1016/S1074-7613(01)00169-8 . free .
• Sheppard P, Kindsvogel W, Xu W, etal . IL-28, IL-29 and their class II cytokine receptor IL-28R. . Nat. Immunol. . 4 . 1 . 63–8 . 2003 . 12469119 . 10.1038/ni873 . 35764259 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Kotenko SV, Gallagher G, Baurin VV, etal . IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. . Nat. Immunol. . 4 . 1 . 69–77 . 2003 . 12483210 . 10.1038/ni875 . 2734534 .
• Hör S, Pirzer H, Dumoutier L, etal . The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains. . J. Biol. Chem. . 279 . 32 . 33343–51 . 2004 . 15178681 . 10.1074/jbc.M405000200 . free .
• Zhang Z, Henzel WJ . Signal peptide prediction based on analysis of experimentally verified cleavage sites. . Protein Sci. . 13 . 10 . 2819–24 . 2005 . 15340161 . 10.1110/ps.04682504 . 2286551 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Pletnev S, Magracheva E, Wlodawer A, Zdanov A . A model of the ternary complex of interleukin-10 with its soluble receptors. . BMC Struct. Biol. . 5. 10 . 2006 . 15985167 . 10.1186/1472-6807-5-10 . 1192808 . free .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .

Notes and References

1. Web site: Entrez Gene: IL10RB interleukin 10 receptor, beta.
2. Web site: Entrez Gene: IL10RB interleukin 10 receptor, beta.