Intelectin-1 Explained

Intelectin-1, also known as omentin or intestinal lactoferrin receptor, is an intelectin encoded in humans by the ITLN1 gene.^{[1] [2] [3]} Intelectin-1 functions both as a receptor for bacterial arabinogalactans^[1] and for lactoferrin.^[4]

Having conserved ligand binding site residues, both human and mouse intelectin-1 bind the exocyclic vicinal diol of carbohydrate ligands such as galactofuranose.^{[5] [6]}

See also

• Intelectin

Further reading

• Suzuki YA, Lopez V, Lönnerdal B . Mammalian lactoferrin receptors: structure and function . Cellular and Molecular Life Sciences . 62 . 22 . 2560–75 . November 2005 . 16261254 . 10.1007/s00018-005-5371-1 . 265994535 . 11139119 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Chang BY, Peavy TR, Wardrip NJ, Hedrick JL . The Xenopus laevis cortical granule lectin: cDNA cloning, developmental expression, and identification of the eglectin family of lectins . Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology . 137 . 1 . 115–29 . January 2004 . 14720597 . 10.1016/S1095-6433(03)00269-1 .
• Wali A, Morin PJ, Hough CD, Lonardo F, Seya T, Carbone M, Pass HI . Identification of intelectin overexpression in malignant pleural mesothelioma by serial analysis of gene expression (SAGE) . Lung Cancer . 48 . 1 . 19–29 . April 2005 . 15777968 . 10.1016/j.lungcan.2004.10.011 .
• Schäffler A, Neumeier M, Herfarth H, Fürst A, Schölmerich J, Büchler C . Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1732 . 1–3 . 96–102 . December 2005 . 16386808 . 10.1016/j.bbaexp.2005.11.005 .
• Yang RZ, Lee MJ, Hu H, Pray J, Wu HB, Hansen BC, Shuldiner AR, Fried SK, McLenithan JC, Gong DW . Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action . American Journal of Physiology. Endocrinology and Metabolism . 290 . 6 . E1253-61 . June 2006 . 16531507 . 10.1152/ajpendo.00572.2004 .
• Schäffler A, Zeitoun M, Wobser H, Buechler C, Aslanidis C, Herfarth H . Frequency and significance of the novel single nucleotide missense polymorphism Val109Asp in the human gene encoding omentin in Caucasian patients with type 2 diabetes mellitus or chronic inflammatory bowel diseases . Cardiovascular Diabetology . 6 . 3 . February 2007 . 17295929 . 1802733 . 10.1186/1475-2840-6-3 . free .
• Wurm S, Neumeier M, Weigert J, Schäffler A, Buechler C . Plasma levels of leptin, omentin, collagenous repeat-containing sequence of 26-kDa protein (CORS-26) and adiponectin before and after oral glucose uptake in slim adults . Cardiovascular Diabetology . 6 . 7 . February 2007 . 17311679 . 1804262 . 10.1186/1475-2840-6-7 . free .
• de Souza Batista CM, Yang RZ, Lee MJ, Glynn NM, Yu DZ, Pray J, Ndubuizu K, Patil S, Schwartz A, Kligman M, Fried SK, Gong DW, Shuldiner AR, Pollin TI, McLenithan JC . Omentin plasma levels and gene expression are decreased in obesity . Diabetes . 56 . 6 . 1655–61 . June 2007 . 17329619 . 10.2337/db06-1506 . free .

Notes and References

1. Tsuji S, Uehori J, Matsumoto M, Suzuki Y, Matsuhisa A, Toyoshima K, Seya T . Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall . The Journal of Biological Chemistry . 276 . 26 . 23456–63 . June 2001 . 11313366 . 10.1074/jbc.M103162200 . free .
2. Lee JK, Schnee J, Pang M, Wolfert M, Baum LG, Moremen KW, Pierce M . Human homologs of the Xenopus oocyte cortical granule lectin XL35 . Glycobiology . 11 . 1 . 65–73 . January 2001 . 11181563 . 10.1093/glycob/11.1.65 . free .
3. Web site: Entrez Gene: ITLN1 intelectin 1 (galactofuranose binding).
4. Suzuki YA, Shin K, Lönnerdal B . Molecular cloning and functional expression of a human intestinal lactoferrin receptor . Biochemistry . 40 . 51 . 15771–9 . December 2001 . 11747454 . 10.1021/bi0155899 .
5. Wesener DA, Wangkanont K, McBride R, Song X, Kraft MB, Hodges HL, Zarling LC, Splain RA, Smith DF, Cummings RD, Paulson JC, Forest KT, Kiessling LL . Recognition of microbial glycans by human intelectin-1 . Nature Structural & Molecular Biology . 22 . 8 . 603–10 . August 2015 . 26148048 . 4526365 . 10.1038/nsmb.3053 .
6. Wangkanont K, Wesener DA, Vidani JA, Kiessling LL, Forest KT . Structures of Xenopus Embryonic Epidermal Lectin Reveal a Conserved Mechanism of Microbial Glycan Recognition . The Journal of Biological Chemistry . 291 . 11 . 5596–610 . March 2016 . 26755729 . 4786701 . 10.1074/jbc.M115.709212 . free .