Integrin alpha 2 explained
Integrin alpha-2, or CD49b (cluster of differentiation 49b), is a protein which in humans is encoded by the CD49b gene.
The CD49b protein is an integrin alpha subunit. It makes up half of the α2β1 integrin duplex. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including T cells (the NKT cells), NK cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface-mediated signalling.[1]
Expression of CD49b in conjunction with LAG-3 has been used to identify type 1 regulatory (Tr1) cells.[2]
The DX5 monoclonal antibody recognizes mouse CD49b.[3]
Interactions
CD49b has been shown to interact with MMP1.[4] [5]
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Integrin alpha 2
Further reading
- Moroi M, Jung SM . Platelet receptors for collagen. . Thromb. Haemost. . 78 . 1 . 439–44 . 1997 . 9198193 . 10.1055/s-0038-1657566. 8121197 .
- Takada Y, Kamata T, Irie A, Puzon-McLaughlin W, Zhang XP . Structural basis of integrin-mediated signal transduction. . Matrix Biol. . 16 . 4 . 143–51 . 1998 . 9402003 . 10.1016/S0945-053X(97)90002-0 .
- Dickeson SK, Santoro SA . Ligand recognition by the I domain-containing integrins. . Cell. Mol. Life Sci. . 54 . 6 . 556–66 . 1998 . 9676575 . 10.1007/s000180050184 . 9775686 . 11147323 .
- Porter JC, Hogg N . Integrins take partners: cross-talk between integrins and other membrane receptors. . Trends Cell Biol. . 8 . 10 . 390–6 . 1999 . 9789327 . 10.1016/S0962-8924(98)01344-0 .
- Plenz GA, Deng MC, Robenek H, Völker W . Vascular collagens: spotlight on the role of type VIII collagen in atherogenesis. . Atherosclerosis . 166 . 1 . 1–11 . 2003 . 12482545 . 10.1016/S0021-9150(01)00766-3 .
- Charakida M, Tousoulis D, Stefanadis C, Toutouzas P . The impact of platelet glycoprotein IIIa and Ia polymorphisms in cardiovascular thrombotic disease. . Italian Heart Journal . 4 . 1 . 17–22 . 2003 . 12690916 .
- Tsantes AE, Nikolopoulos GK, Bagos PG, Vaiopoulos G, Travlou A . Lack of association between the platelet glycoprotein Ia C807T gene polymorphism and coronary artery disease: a meta-analysis. . Int. J. Cardiol. . 118 . 2 . 189–96 . 2007 . 17023078 . 10.1016/j.ijcard.2006.06.047 .
External links
Notes and References
- Web site: Entrez Gene: ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor).
- Gagliani. Nicola. Magnani. Chiara F.. Huber. Samuel. Gianolini. Monica E.. Pala. Mauro. Licona-Limon. Paula. Guo. Binggege. Herbert. De'Broski R.. Bulfone. Alessandro. 2013-06-01. Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells. Nature Medicine. 19. 6. 739–746. 10.1038/nm.3179. 1546-170X. 23624599. 21305032.
- Arase H, Saito T, Phillips JH, Lanier LL . Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin, very late antigen-2) . Journal of Immunology . 167 . 3 . 1141–4 . August 2001 . 11466327 . 10.4049/jimmunol.167.3.1141 . free .
- Stricker TP, Dumin JA, Dickeson SK, Chung L, Nagase H, Parks WC, Santoro SA . Structural analysis of the alpha(2) integrin I domain/procollagenase-1 (matrix metalloproteinase-1) interaction . J. Biol. Chem. . 276 . 31 . 29375–81 . Aug 2001 . 11359774 . 10.1074/jbc.M102217200 . free .
- Dumin JA, Dickeson SK, Stricker TP, Bhattacharyya-Pakrasi M, Roby JD, Santoro SA, Parks WC . Pro-collagenase-1 (matrix metalloproteinase-1) binds the alpha(2)beta(1) integrin upon release from keratinocytes migrating on type I collagen . J. Biol. Chem. . 276 . 31 . 29368–74 . Aug 2001 . 11359786 . 10.1074/jbc.M104179200 . free .
