Integral monotopic protein explained

Integral monotopic proteins are permanently attached to the cell membrane from one side, and are a type of integral membrane protein (IMP).^[1]

Three-dimensional structures of the following integral monotopic proteins have been determined:

• prostaglandin H2 syntheses 1 and 2 (cyclooxygenases)
• lanosterol synthase and squalene-hopene cyclase
• microsomal prostaglandin E synthase
• carnitine O-palmitoyltransferase 2

There are also structures of integral monotopic domains of transmembrane proteins:

• monoamine oxidases A and B
• fatty acid amide hydrolase
• mammalian cytochrome P450 oxidases
• corticosteroid 11-beta-dehydrogenases

Notes and References

1. Fowler. Philip W.. Coveney. Peter V.. A Computational Protocol for the Integration of the Monotopic Protein Prostaglandin H2 Synthase into a Phospholipid Bilayer. Biophysical Journal. July 2006. 91. 2. 401–410. 10.1529/biophysj.105.077784. 1483072. 16632499.