Inositol-polyphosphate multikinase explained
| Inositol-polyphosphate multikinase |
| Ec Number: | 2.7.1.151 |
| Cas Number: | 9077-69-4 |
Inositol-polyphosphate multikinase (IpK2, IP3/IP4 6-/3-kinase, IP3/IP4 dual-specificity 6-/3-kinase, IpmK, ArgRIII, AtIpk2alpha, AtIpk2beta, inositol polyphosphate 6-/3-/5-kinase) is an enzyme with systematic name ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase.[1] [2] [3] [4] This enzyme catalyses the following chemical reaction
2 ATP + 1D-myo-inositol 1,4,5-trisphosphate
2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (overall reaction)
(1a) ATP + 1D-myo-inositol 1,4,5-trisphosphate
ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
(1b) ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
This enzyme also phosphorylates Ins(1,4,5)P3 to Ins(1,3,4,5)P4, Ins(1,3,4,5)P4 to Ins(1,3,4,5,6)P5, and Ins(1,3,4,5,6)P4 to Ins(PP)P4, isomer unknown.
Notes and References
- Saiardi A, Erdjument-Bromage H, Snowman AM, Tempst P, Snyder SH . Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases . Current Biology . 9 . 22 . 1323–6 . November 1999 . 10574768 . 10.1016/S0960-9822(00)80055-X . free .
- Odom AR, Stahlberg A, Wente SR, York JD . A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control . Science . 287 . 5460 . 2026–9 . March 2000 . 10720331 . 10.1126/science.287.5460.2026 .
- Stevenson-Paulik J, Odom AR, York JD . Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases . The Journal of Biological Chemistry . 277 . 45 . 42711–8 . November 2002 . 12226109 . 10.1074/jbc.M209112200 . free .
- Verbsky JW, Chang SC, Wilson MP, Mochizuki Y, Majerus PW . The pathway for the production of inositol hexakisphosphate in human cells . The Journal of Biological Chemistry . 280 . 3 . 1911–20 . January 2005 . 15531582 . 10.1074/jbc.M411528200 . free .
