Inositol-polyphosphate 5-phosphatase explained

Inositol-polyphosphate 5-phosphatase
Ec Number:	3.1.3.56
Cas Number:	106283-14-1

The enzyme inositol-polyphosphate 5-phosphatase, systematic name 1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase, catalyses the following reactions:

(1) D-myo-inositol 1,4,5-trisphosphate + H₂O

\rightleftharpoons myo-inositol 1,4-bisphosphate + phosphate

(2) 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H₂O

\rightleftharpoons 1D-myo-inositol 1,3,4-trisphosphate + phosphate

Ten mammalian isoforms are known.^[1]

Other names of this enzyme include type I inositol-polyphosphate phosphatase, inositol trisphosphate phosphomonoesterase, InsP₃/Ins(1,3,4,5)P₄ 5-phosphatase, inosine triphosphatase, D-myo-inositol 1,4,5-triphosphate 5-phosphatase, D-myo-inositol 1,4,5-trisphosphate 5-phosphatase, L-myo-inositol 1,4,5-trisphosphate-monoesterase, inositol phosphate 5-phosphomonoesterase, inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase, Ins(1,4,5)P₃ 5-phosphataseD-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase, inositol 1,4,5-trisphosphate phosphatase, inositol polyphosphate-5-phosphatase, myo-inositol-1,4,5-trisphosphate 5-phosphatase, inositol-1,4,5-trisphosphate 5-phosphatase.^{[2] [3] [4] [5]}

Notes and References

1. Ooms LM, Horan KA, Rahman P, Seaton G, Gurung R, Kethesparan DS, Mitchell CA . The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease . The Biochemical Journal . 419 (Pt 1) . 29–49 . 2009 . 19272022 . 10.1042/BJ20081673 .
2. Downes CP, Mussat MC, Michell RH . April 1982 . The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane . The Biochemical Journal . 203 . 1 . 169–77 . 10.1042/bj2030169 . 1158207 . 6285891.
3. Erneux C, Lemos M, Verjans B, Vanderhaeghen P, Delvaux A, Dumont JE . May 1989 . Soluble and particulate Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase in bovine brain . European Journal of Biochemistry . 181 . 2 . 317–22 . 10.1111/j.1432-1033.1989.tb14726.x . 2540972 . free.
4. Book: Woscholski, R. . Biology of Phosphoinositides . Parker, P.J. . Biology of Phosphoinositides . 2000 . Cockcroft, S. . Oxford . 320–338 . Inositol phosphatases: constructive destruction of phosphoinositides and inositol phosphates.
5. Verjans B, De Smedt F, Lecocq R, Vanweyenberg V, Moreau C, Erneux C . May 1994 . Cloning and expression in Escherichia coli of a dog thyroid cDNA encoding a novel inositol 1,4,5-trisphosphate 5-phosphatase . The Biochemical Journal . 300 (Pt 1) . 85–90 . 10.1042/bj3000085 . 1138127 . 8198557.