Inositol-1,3,4-trisphosphate 5/6-kinase explained

inositol-1,3,4-trisphosphate 5/6-kinase
Ec Number:	2.7.1.159
Cas Number:	288307-53-9

inositol-1,3,4-trisphosphate 5/6-kinase (Ins(1,3,4)P3 5/6-kinase, inositol trisphosphate 5/6-kinase) is an enzyme with systematic name ATP:1D-myo-inositol 1,3,4-trisphosphate 5-phosphotransferase.^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

(1) ATP + 1D-myo-inositol 1,3,4-trisphosphate

\rightleftharpoons ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate

(2) ATP + 1D-myo-inositol 1,3,4-trisphosphate

\rightleftharpoons ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate

In humans, this enzyme, along with EC 2.7.1.127 (inositol-trisphosphate 3-kinase), EC 2.7.1.140 (inositol-tetrakisphosphate 5-kinase) and EC 2.7.1.158 (inositol pentakisphosphate 2-kinase) is involved in the production of inositol hexakisphosphate (InsP6).

Notes and References

1. Wilson MP, Majerus PW . Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme . The Journal of Biological Chemistry . 271 . 20 . 11904–10 . May 1996 . 8662638 . 10.1074/jbc.271.20.11904 . free .
2. Verbsky JW, Chang SC, Wilson MP, Mochizuki Y, Majerus PW . The pathway for the production of inositol hexakisphosphate in human cells . The Journal of Biological Chemistry . 280 . 3 . 1911–20 . January 2005 . 15531582 . 10.1074/jbc.M411528200 . free .
3. Miller GJ, Wilson MP, Majerus PW, Hurley JH . Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase . Molecular Cell . 18 . 2 . 201–12 . April 2005 . 15837423 . 10.1016/j.molcel.2005.03.016 . free .