Indolepyruvate ferredoxin oxidoreductase explained

indolepyruvate ferredoxin oxidoreductase
Ec Number:	1.2.7.8
Go Code:	0043805

In enzymology, an indolepyruvate ferredoxin oxidoreductase is an enzyme that catalyzes the chemical reaction

(indol-3-yl)pyruvate + CoA + oxidized ferredoxin

\rightleftharpoons S-2-(indol-3-yl)acetyl-CoA + CO₂ + reduced ferredoxin

The 3 substrates of this enzyme are (indol-3-yl)pyruvate, CoA, and oxidized ferredoxin, whereas its 3 products are S-2-(indol-3-yl)acetyl-CoA, CO₂, and reduced ferredoxin.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with an iron-sulfur protein as acceptor. The systematic name of this enzyme class is 3-(indol-3-yl)pyruvate:ferredoxin oxidoreductase (decarboxylating, CoA-indole-acetylating). Other names in common use include 3-(indol-3-yl)pyruvate synthase (ferredoxin), and IOR.

References

• Mai X, Adams MW . 1994 . Indolepyruvate ferredoxin oxidoreductase from the hyperthermophilic archaeon Pyrococcus furiosus. A new enzyme involved in peptide fermentation . J. Biol. Chem. . 269 . 16726 - 32 . 8206994 . 24 . 10.1016/S0021-9258(19)89451-6 . free .
• Siddiqui MA, Fujiwara S, Imanaka T . 1997 . Indolepyruvate ferredoxin oxidoreductase from Pyrococcus sp. KOD1 possesses a mosaic structure showing features of various oxidoreductases . Mol. Gen. Genet. . 254 . 433 - 9 . 9180697 . 10.1007/PL00008607 . 4 .
• Tersteegen A, Linder D, Thauer RK, Hedderich R . 1997 . Structures and functions of four anabolic 2-oxoacid oxidoreductases in Methanobacterium thermoautotrophicum . Eur. J. Biochem. . 244 . 862 - 8 . 9108258 . 10.1111/j.1432-1033.1997.00862.x . 3 . free .
• Book: Schut GJ, Menon AL, Adams MW . 2001 . 2-keto acid oxidoreductases from Pyrococcus furiosus and Thermococcus litoralis . 2-keto acid oxidoreductases from Pyrococcus furiosus and Thennococcus litoralis . Methods Enzymol. . 331 . 144 - 58 . 11265457 . 10.1016/S0076-6879(01)31053-4 . 978-0-12-182232-3 .