Imidazothiazoles Explained

Imidazothiazoles are a class of chemical compounds containing a bicyclic heterocycle (a double ring system) consisting of an imidazole ring fused to a thiazole ring.[1] The structure contains three non-carbon or heteroatoms: two nitrogen atoms and one sulfur atom. Imidazothiazole derivatives show a broad spectrum of in vitro, i.e. "in the petri dish", activity such as anticancer,[2] [3] [4] antipsychotic,[5] antimicrobial,[6] antifungal,[7] and anthelmintic[8] (against cancer, psychosis, microorganisms, fungi and worms, respectively).

References

  1. Fascio. Mirta L.. Errea. María Inés. D'Accorso. Norma Beatriz. 2015-01-27. Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties. European Journal of Medicinal Chemistry. en. 90. 666–683. 10.1016/j.ejmech.2014.12.012. 25499987. 11336/17776. free.
  2. Gürsoy. Elif. Güzeldemirci. Nuray Ulusoy. 2007-03-01. Synthesis and primary cytotoxicity evaluation of new imidazo[2,1-b]thiazole derivatives. European Journal of Medicinal Chemistry. en. 42. 3. 320–326. 10.1016/j.ejmech.2006.10.012. 17145120.
  3. Andreani. Aldo. Granaiola. Massimiliano. Leoni. Alberto. Locatelli. Alessandra. Morigi. Rita. Rambaldi. Mirella. Varoli. Lucilla. Lannigan. Deborah. Smith. Jeff. Scudiero. Dominic. Kondapaka. Sudhir. 2011-09-01. Imidazo[2,1-b]thiazole guanylhydrazones as RSK2 inhibitors [1]. European Journal of Medicinal Chemistry. en. 46. 9. 4311–4323. 10.1016/j.ejmech.2011.07.001. 21794960. 11585/105011. free.
  4. Park. Jin-Hun. El-Gamal. Mohammed I.. Lee. Yong Sup. Oh. Chang-Hyun. 2011-12-01. New imidazo[2,1-b]thiazole derivatives: Synthesis, in vitro anticancer evaluation, and in silico studies. European Journal of Medicinal Chemistry. en. 46. 12. 5769–5777. 10.1016/j.ejmech.2011.08.024. 22033063.
  5. Cole. Derek C.. Stock. Joseph R.. Lennox. William J.. Bernotas. Ronald C.. Ellingboe. John W.. Boikess. Steve. Coupet. Joseph. Smith. Deborah L.. Leung. Louis. Zhang. Guo-Ming. Feng. Xidong. 2007-11-01. Discovery of N1-(6-Chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a Potent, Selective, and Orally Active 5-HT6 Receptor Agonist. Journal of Medicinal Chemistry. 50. 23. 5535–5538. 10.1021/jm070521y. 17948978.
  6. Güzeldemirci. Nuray Ulusoy. Küçükbasmacı. Ömer. 2010-01-01. Synthesis and antimicrobial activity evaluation of new 1,2,4-triazoles and 1,3,4-thiadiazoles bearing imidazo[2,1-b]thiazole moiety. European Journal of Medicinal Chemistry. en. 45. 1. 63–68. 10.1016/j.ejmech.2009.09.024. 19939519.
  7. 2013-01-01. Synthesis, characterization and evaluation for antifungal activity of substituted diaryl imidazo [2, 1, b]-benzothiazole. Journal of Pharmacy Research. en. 7. 1. 39–46. 10.1016/j.jopr.2013.01.002. Malik. Jitender K.. Soni. Himesh. Singhai. A.K.. free.
  8. Amarouch. Hamid. Loiseau. Philippe R. Bacha. Catarina. Caujolle. Raymond. Payard. Marc. Loiseau. Philippe M. Bories. Christian. Gayral. Philippe. 1987-09-01. Imidazo[2,1-b]thiazoles: analogues du lévamisole. European Journal of Medicinal Chemistry. fr. 22. 5. 463–466. 10.1016/0223-5234(87)90037-7.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Imidazothiazoles".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.