Imidazolonepropionase Explained

imidazolonepropionase
Ec Number:	3.5.2.7
Cas Number:	9024-91-3
Go Code:	0050480
Width:	270

In enzymology, an imidazolonepropionase is an enzyme that catalyzes the chemical reaction

(S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H₂O

\rightleftharpoons N-formimidoyl-L-glutamate + H⁺

Thus, the two substrates of this enzyme are (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate and H₂O, whereas its two products are N-formimidoyl-L-glutamate and H⁺.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amides. The systematic name of this enzyme class is 3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate amidohydrolase. Other names in common use include 4(5)-imidazolone-5(4)-propionic acid hydrolase, and imidazolone propionic acid hydrolase. This enzyme participates in histidine metabolism.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes,,,,, and .

References

• Rao DR . Greenberg DM . 1961 . Studies on the enzymic decomposition of urocanic acid. IV Purification and properties of 4(5)-imidazolone-5(4)-propionic acid hydrolase . J. Biol. Chem. . 236 . 1758 - 1763 . 13739526.
• Snyder SH, Silva OL, Kies MW . 1961 . The mammalian metabolism of L-histidine. IV. Purification and properties of imidazolone propionic acid hydrolase . J. Biol. Chem. . 236 . 2996 - 2998 . 13914653.