Idebenone Explained

Idebenone (pronounced eye-deb-eh-known, trade names Catena, Raxone, Sovrima, among others) is a drug that was initially developed by Takeda Pharmaceutical Company for the treatment of Alzheimer's disease and other cognitive defects.[1] This has been met with limited success. The Swiss company Santhera Pharmaceuticals has started to investigate it for the treatment of neuromuscular diseases. In 2010, early clinical trials for the treatment of Friedreich's ataxia and Duchenne muscular dystrophy have been completed. the drug is not approved for these indications in North America or Europe. It is approved by the European Medicines Agency (EMA) for use in Leber's hereditary optic neuropathy (LHON) and was designated an orphan drug in 2007.[2]

Chemically, idebenone is an organic compound of the quinone family. It is also promoted commercially as a synthetic analog of coenzyme Q10 (CoQ10).

Uses

Indications that are or were approved in some territories

Nootropic effects and Alzheimer's disease

Idebenone improved learning and memory in experiments with mice.[3] In humans, evaluation of Surrogate endpoints like electroretinography, auditory evoked potentials and visual analogue scales also suggested positive nootropic effects,[4] but larger studies with hard endpoints are missing.

Research on idebenone as a potential therapy of Alzheimer's disease have been inconsistent, but there may be a trend for a slight benefit.[5] [6] In May 1998, the approval for this indication was cancelled in Japan due to the lack of proven effects. In some European countries, the drug is available for the treatment of individual patients in special cases.

Friedreich's ataxia (Sovrima)

Preliminary testing has been done in humans and found idebenone to be a safe treatment for Friedreich's ataxia (FA), exhibiting a positive effect on cardiac hypertrophy and neurological function.[7] The latter was only significantly improved in young patients.[8] In a different experiment, a one-year test on eight patients, idebenone reduced the rate of deterioration of cardiac function, but without halting the progression of ataxia.[9]

The drug was approved for FA in Canada in 2008 under conditions including proof of efficacy in further clinical trials.[10] However, on February 27, 2013, Health Canada announced that idebenone would be voluntarily recalled as of April 30, 2013 by its Canadian manufacturer, Santhera Pharmaceuticals, due to the failure of the drug to show efficacy in the further clinical trials that were conducted.[11] In 2008, the European Medicines Agency (EMA) refused a marketing authorisation for this indication. As of 2013 the drug was not approved for FA in Europe[12] nor in the US, where, as of February 2023, there is only one approved treatment.[13]

Leber's hereditary optic neuropathy (Raxone)

Leber's hereditary optic neuropathy (LHON) is a mitochondrially inherited (mother to all offspring) degeneration of retinal ganglion cells (RGCs) and their axons that leads to an acute or subacute loss of central vision; this affects predominantly young adult males. Santhera completed a Phase III clinical trial in this indication in Europe with positive results,[14] and submitted an application to market the drug to European regulators in July 2011.[15] It is approved by EMA for this indication and was designated an orphan drug in 2007.

Indications being explored

Duchenne muscular dystrophy (Catena)

After experiments in mice[16] and preliminary studies in humans, idebenone has entered Phase II clinical trials in 2005 and Phase III trials in 2009.

Other neuromuscular diseases

Phase I and II clinical trial for the treatment of MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes) was conducted. Phase I/II trial for primary progressive multiple sclerosis concluded that Idebenone did not inhibit disability progression.[17]

As of 2022, a phase III clinical trial is ongoing for the treatment of Parkinson's disease.[18]

Life style

Idebenone is claimed to have properties similar to CoQ10 in its antioxidant properties, and has therefore been used in anti-aging on the basis of free-radical theory. Clinical evidence for this use is missing. It has been used in topical applications to treat wrinkles.[19]

Pharmacology

In cellular and tissue models, idebenone acts as a transporter in the electron transport chain of mitochondria and thus increases the production of adenosine triphosphate (ATP) which is the main energy source for cells, and also inhibits lipoperoxide formation. Positive effects on the energy household of mitochondria has also been observed in animal models.[20] Clinical relevance of these findings has not been established.

Pharmacokinetics

Idebenone is well absorbed from the gut but undergoes excessive first pass metabolism in the liver, so that less than 1% reach the circulation. This rate can be improved with special formulations (suspensions) of idebenone and by administering it together with fat food; but even taking these measures bioavailability still seems to be considerably less than 14% in humans. More than 99% of the circulating drug are bound to plasma proteins. Idebenone metabolites include glucuronides and sulfates, which are mainly (~80%) excreted via the urine.

Notes and References

  1. CHMP Assessment Report for Sovrima. European Medicines Agency. 20 November 2008. 6, 9–11, 67f.
  2. Web site: Raxone. www.ema.europa.eu. 17 September 2018 . 12 July 2019.
  3. Liu XJ, Wu WT . Effects of ligustrazine, tanshinone II A, ubiquinone, and idebenone on mouse water maze performance . Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica . 20 . 11 . 987–990 . November 1999 . 11270979 .
  4. Schaffler K, Hadler D, Stark M . Dose-effect relationship of idebenone in an experimental cerebral deficit model. Pilot study in healthy young volunteers with piracetam as reference drug . Arzneimittel-Forschung . 48 . 7 . 720–726 . July 1998 . 9706371 .
  5. Gutzmann H, Kühl KP, Hadler D, Rapp MA . Safety and efficacy of idebenone versus tacrine in patients with Alzheimer's disease: results of a randomized, double-blind, parallel-group multicenter study . Pharmacopsychiatry . 35 . 1 . 12–18 . January 2002 . 11819153 . 10.1055/s-2002-19833 .
  6. Parnetti L, Senin U, Mecocci P . Cognitive enhancement therapy for Alzheimer's disease. The way forward . Drugs . 53 . 5 . 752–768 . May 1997 . 9129864 . 10.2165/00003495-199753050-00003 . 46987059 .
  7. Di Prospero NA, Baker A, Jeffries N, Fischbeck KH . Neurological effects of high-dose idebenone in patients with Friedreich's ataxia: a randomised, placebo-controlled trial . The Lancet. Neurology . 6 . 10 . 878–886 . October 2007 . 17826341 . 10.1016/S1474-4422(07)70220-X . 24749816 .
  8. Tonon C, Lodi R . Idebenone in Friedreich's ataxia . Expert Opinion on Pharmacotherapy . 9 . 13 . 2327–2337 . September 2008 . 18710357 . 10.1517/14656566.9.13.2327 . 73285881 .
  9. Buyse G, Mertens L, Di Salvo G, Matthijs I, Weidemann F, Eyskens B, Goossens W, Goemans N, Sutherland GR, Van Hove JL . 6 . Idebenone treatment in Friedreich's ataxia: neurological, cardiac, and biochemical monitoring . Neurology . 60 . 10 . 1679–1681 . May 2003 . 12771265 . 10.1212/01.wnl.0000068549.52812.0f . 36556782 .
  10. Web site: Heath Canada Fact Sheet - Catena. https://web.archive.org/web/20140619110910/http://www.hc-sc.gc.ca/dhp-mps/prodpharma/notices-avis/conditions/catena_fs_fd_117672-eng.php. 19 June 2014. dead.
  11. http://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2013/23509a-eng.php Voluntary Withdrawal of Catena from the Canadian Market
  12. Margaret Wahl for Quest Magazine, MAY 28, 2010. FA Research: Idebenone Strikes Out Again
  13. https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-first-treatment-friedreichs-ataxia#:~:text=FDA%20has%20approved%20Skyclarys%20(omaveloxolone,recommended%20dosage%20of%20150%20mg. FDA approves first treatment for Friedreich’s ataxia
  14. Klopstock T, Yu-Wai-Man P, Dimitriadis K, Rouleau J, Heck S, Bailie M, Atawan A, Chattopadhyay S, Schubert M, Garip A, Kernt M, Petraki D, Rummey C, Leinonen M, Metz G, Griffiths PG, Meier T, Chinnery PF . 6 . A randomized placebo-controlled trial of idebenone in Leber's hereditary optic neuropathy . Brain . 134 . Pt 9 . 2677–2686 . September 2011 . 21788663 . 3170530 . 10.1093/brain/awr170 .
  15. Web site: Staff. European Biotechnology News. 26 July 2011. Santhera publishes pivotal trial results of idebenone and goes for EU approval. https://archive.today/20130217112149/http://www.eurobiotechnews.eu/news/messages-archive/archive/article/santhera-publishes-pivotal-trial-results-of-idebenone-and-goes-for-eu-approval.html. 2013-02-17. dead.
  16. Buyse GM, Van der Mieren G, Erb M, D'hooge J, Herijgers P, Verbeken E, Jara A, Van Den Bergh A, Mertens L, Courdier-Fruh I, Barzaghi P, Meier T . 6 . Long-term blinded placebo-controlled study of SNT-MC17/idebenone in the dystrophin deficient mdx mouse: cardiac protection and improved exercise performance . European Heart Journal . 30 . 1 . 116–124 . January 2009 . 18784063 . 2639086 . 10.1093/eurheartj/ehn406 .
  17. Kosa P, Wu T, Phillips J, Leinonen M, Masvekar R, Komori M, Wichman A, Sandford M, Bielekova B . 6 . Idebenone does not inhibit disability progression in primary progressive MS . Multiple Sclerosis and Related Disorders . 45 . 102434 . October 2020 . 32784117 . 9386688 . 10.1016/j.msard.2020.102434 .
  18. McFarthing K, Rafaloff G, Baptista M, Mursaleen L, Fuest R, Wyse RK, Stott SR . Parkinson's Disease Drug Therapies in the Clinical Trial Pipeline: 2022 Update . Journal of Parkinson's Disease . 12 . 4 . 1073–1082 . 2022 . 35527571 . 9198738 . 10.3233/JPD-229002 .
  19. McDaniel DH, Neudecker BA, DiNardo JC, Lewis JA, Maibach HI . Clinical efficacy assessment in photodamaged skin of 0.5% and 1.0% idebenone . Journal of Cosmetic Dermatology . 4 . 3 . 167–173 . September 2005 . 17129261 . 10.1111/j.1473-2165.2005.00305.x . 2394666 .
  20. Suno M, Nagaoka A . [Effect of idebenone and various nootropic drugs on lipid peroxidation in rat brain homogenate in the presence of succinate] . ja . Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica . 91 . 5 . 295–299 . May 1988 . 3410376 . 10.1254/fpj.91.295 . free .

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