Hypoalphalipoproteinemia Explained

Hypoalphalipoproteinemia is a high-density lipoprotein deficiency, inherited in an autosomal dominant manner.

It can be associated with LDL receptor.^[1]

Associated regions and genes include:

Name	OMIM	Locus	Candidates
HDLCQ1		9p	ABCA1 (Tangier disease)^[2]
HDLCQ2		8q23
HDLCQ3		16q24.1	Lecithin cholesterol acyltransferase deficiency (LCAT)
HDLCQ4		4q32
HDLD3		11q23.3	APOA1

niacin is sometimes prescribed to raise HDL levels.

See also

• CER-001

Notes and References

1. Pisciotta L, Calabresi L, Lupattelli G, etal . Combined monogenic hypercholesterolemia and hypoalphalipoproteinemia caused by mutations in LDL-R and LCAT genes . Atherosclerosis . 182 . 1 . 153–9 . September 2005 . 16115486 . 10.1016/j.atherosclerosis.2005.01.048 .
2. Soro-Paavonen A, Naukkarinen J, Lee-Rueckert M, etal . Common ABCA1 variants, HDL levels, and cellular cholesterol efflux in subjects with familial low HDL . J. Lipid Res. . 48 . 6 . 1409–16 . June 2007 . 17372331 . 10.1194/jlr.P600012-JLR200 . free .