Hypertrichosis cubiti explained

Synonym:hairy elbow syndrome
Specialty:Dermatology

Hypertrichosis cubiti (also known as "hairy elbow syndrome") is a cutaneous condition characterized by multiple terminal hairs on both elbows in children.[1]

Signs and symptoms

Hypertrichosis cubiti is characterized by an unusually high concentration of longhairs that are concentrated mostly in the elbow area on the extensor surfaces of the upper extremities. Hypertrichosis is not always visible at birth; it typically manifests in early infancy, peaks between the ages of 5 and 6, then gradually declines and eventually goes away during puberty.[2]

Causes

Several inheritance patterns with varying penetrance and expressivity have been proposed, such as a familial pattern with either an autosomal dominant or autosomal recessive inheritance.[3] Primary nevoid hypertrichosis[4] [5] and somatic hypertrichosis mosaicism are two other possibilities.[6] [7] There have been some speculative connections made to disorders including the Floating-Harbor syndrome,[8] Wiedemann-Steiner syndrome,[9] and Weill-Marchesani syndrome.[10]

Treatment

For children with sporadic hypertrichosis cubiti, parents should be reassured and given guidance on hair removal or bleaching. Care should be used while discussing hair removal methods in order to reduce discomfort and expense.[3]

See also

Further reading

Notes and References

  1. Book: Rapini, Ronald P. . Bolognia, Jean L. . Jorizzo, Joseph L. . Dermatology: 2-Volume Set . Mosby . St. Louis . 2007 . 978-1-4160-2999-1 .
  2. Nardello . R . Mangano . S . Fontana . A . Tripi . G . Didato . M A . Di Pace . M . Corsello . G . The hairy elbows syndrome: clinical and neuroradiological findings . La Pediatria Medica e Chirurgica: Medical and Surgical Pediatrics . 2008 . 30 . 5 . 262–264 . 19320141 . 17 March 2024.
  3. Tng . Vivian E.T. . de Zwaan . Sally . Hypertrichosis cubiti, a case report and literature review . Clinical Case Reports . Wiley . 4 . 2 . 2015-12-09 . 2050-0904 . 10.1002/ccr3.465 . 138–142. 26862409 . 4736513 .
  4. Andreev . Vladimir C. . Hairy Elbows . Archives of Dermatology . 115 . 6 . 1979-06-01 . 0003-987X . 10.1001/archderm.1979.04010060059036 . 761. 453885 .
  5. Fernandez-Crehuet . Pablo . Ruiz-Villaverde . Ricardo . Fernandez-Crehuet Serrano . Jose Luis . Hairy elbows — A case study . Australian Family Physician . November 2013 . 42 . 11 . 801–802 . 24217102 . 17 March 2024.
  6. Edwards . Matthew J. . Crawford . Anthony E. . Jammu . Vapinder . Wise . Graham . Hypertrichosis "cubiti" with facial asymmetry . American Journal of Medical Genetics . Wiley . 53 . 1 . 1994-10-15 . 0148-7299 . 10.1002/ajmg.1320530112 . 56–58. 7802037 .
  7. Polizzi . A. . Pavone . P. . Ciancio . E. . Rosa . C. La . Sorge . G. . Ruggieri . M. . Hypertrichosis Cubiti (Hairy Elbow Syndrome): A Clue to a Malformation Syndrome . Journal of Pediatric Endocrinology and Metabolism . Walter de Gruyter GmbH . 18 . 10 . 2005 . 1019–1025 . 2191-0251 . 10.1515/jpem.2005.18.10.1019 . 16355816 .
  8. Koç . A . Karaer . K . Ergün . M A . Cinaz . P . Perçin . E F . A new case of hairy elbows syndrome (hypertrichosis cubiti) . Genetic Counseling (Geneva, Switzerland) . 2007 . 18 . 3 . 325–330 . 18019374.
  9. Jones . Wendy D. . Dafou . Dimitra . McEntagart . Meriel . Woollard . Wesley J. . Elmslie . France V. . Holder-Espinasse . Muriel . Irving . Melita . Saggar . Anand K. . Smithson . Sarah . Trembath . Richard C. . Deshpande . Charu . Simpson . Michael A. . De Novo Mutations in MLL Cause Wiedemann-Steiner Syndrome . The American Journal of Human Genetics . Elsevier BV . 91 . 2 . 2012 . 0002-9297 . 10.1016/j.ajhg.2012.06.008 . 358–364. 22795537 . 3415539 .
  10. Beighton . P . Familial hypertrichosis cubiti: hairy elbows syndrome. . Journal of Medical Genetics . BMJ . 7 . 2 . 1970-06-01 . 1468-6244 . 10.1136/jmg.7.2.158 . 158–160. 5519603 . 1468803 .

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