Hygromycin B 4-O-kinase explained

Hygromycin B 4-O-kinase
Ec Number:	2.7.1.163

Hygromycin B 4-O-kinase (hygromycin-B kinase) is an enzyme with systematic name ATP:hygromycin-B 4-O-phosphotransferase.^[1] This enzyme catalyses the following chemical reaction

\rightleftharpoons ADP + 4-O-phosphohygromycin B

Phosphorylates the antibiotic hygromycin B.

Notes and References

1. Rao RN, Allen NE, Hobbs JN, Alborn WE, Kirst HA, Paschal JW . Genetic and enzymatic basis of hygromycin B resistance in Escherichia coli . Antimicrobial Agents and Chemotherapy . 24 . 5 . 689–95 . November 1983 . 6318654 . 185926 . 10.1128/aac.24.5.689 .