Hydroxymethylglutaryl-CoA reductase (NADPH) explained
| hydroxymethylglutaryl-CoA reductase (NADPH) |
| Ec Number: | 1.1.1.34 |
| Cas Number: | 9028-35-7 |
| Go Code: | 0004420 |
| Width: | 270 |
In enzymology, a hydroxymethylglutaryl-CoA reductase (NADPH) is an enzyme that catalyzes the chemical reaction
(R)-mevalonate + CoA + 2 NADP+
(
S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H
+The 3 substrates of this enzyme are (R)-mevalonate, CoA, and NADP+, whereas its 3 products are (S)-3-hydroxy-3-methylglutaryl-CoA, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, to be specific those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. This enzyme participates in biosynthesis of steroids including cholesterol. The statin class of anticholesterol drugs act through inhibiting this enzyme.
Nomenclature
The systematic name of this enzyme class is (R)-mevalonate:NADP+ oxidoreductase (CoA-acylating). Other names in common use include:
- hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate)
- 3-hydroxy-3-methylglutaryl-CoA reductase
- β-hydroxy-β-methylglutaryl coenzyme A reductase
- hydroxymethylglutaryl CoA reductase (NADPH)
- S-3-hydroxy-3-methylglutaryl-CoA reductase
- NADPH-hydroxymethylglutaryl-CoA reductase
- HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating-CoA)
- 3-hydroxy-3-methylglutaryl CoA reductase (NADPH)
- hydroxymethylglutaryl-CoA reductase (NADPH2).
Structural studies
As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes,,,,,,,,,,, and .
References
- Bucher NL, Overath P, Lynen F . 1960 . β-Hydroxy-β-methylglutaryl coenzyme A reductase, cleavage and condensing enzymes in relation to cholesterol formation in rat liver . Biochim. Biophys. Acta . 40 . 491 - 501 . 10.1016/0006-3002(60)91390-1 . 13805544.
- Durr IF, Rudney H . 1960 . The reduction of β-hydroxy-β-methyl-glutaryl coenzyme A to mevalonic acid . J. Biol. Chem. . 235 . 2572 - 8 . 13818862 .
- Kawachi T, Rudney H . 1970 . Solubilization and purification of β-hydroxy-β-methylglutaryl coenzyme A reductase from rat liver . Biochemistry . 9 . 1700 - 5 . 4985697 . 10.1021/bi00810a008 . 8 .
