Hydroxymethylglutaryl-CoA reductase explained

Hydroxymethylglutaryl-CoA reductase
Ec Number:	1.1.1.88
Cas Number:	37250-24-1

In enzymology, a Hydroxymethylglutaryl-CoA reductase is an enzyme that catalyzes the chemical reaction

(R)-mevalonate + CoA + 2 NAD⁺

\rightleftharpoons 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H⁺

The 3 substrates of this enzyme are (R)-mevalonate, CoA, and NAD⁺, whereas its 3 products are 3-hydroxy-3-methylglutaryl-CoA, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (R)-mevalonate:NAD⁺ oxidoreductase (CoA-acylating).^[1] Other names in common use include beta-hydroxy-beta-methylglutaryl coenzyme A reductase, beta-hydroxy-beta-methylglutaryl CoA-reductase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and hydroxymethylglutaryl coenzyme A reductase.

Notes and References

1. Substrate-competitive inhibition of bacterial mevalonate:nicotinamide-adenine dinucleotide oxidoreductase (acylating CoA) . Fimognari GM, Rodwell VW . Biochemistry . 1965 . 4 . 10 . 2086–2090 . 10.1021/bi00886a025.