| hydroxyethylthiazole kinase | |
| Ec Number: | 2.7.1.50 |
| Cas Number: | 9026-56-6 |
| Go Code: | 0004417 |
| Symbol: | HK |
| Hydroxyethylthiazole kinase family | |
| Pfam: | PF02110 |
| Pfam Clan: | CL0118 |
| Interpro: | IPR000417 |
| Scop: | 1c3q |
In enzymology, a hydroxyethylthiazole kinase is an enzyme that catalyzes the chemical reaction
ATP + 4-methyl-5-(2-hydroxyethyl)thiazole
\rightleftharpoons
Thus, the two substrates of this enzyme are ATP and 4-methyl-5-(2-hydroxyethyl)thiazole, whereas its two products are ADP and 4-methyl-5-(2-phosphonooxyethyl)thiazole.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:4-methyl-5-(2-hydroxyethyl)thiazole 2-phosphotransferase. Other names in common use include hydroxyethylthiazole kinase (phosphorylating), and 4-methyl-5-(beta-hydroxyethyl)thiazole kinase. This enzyme participates in thiamine metabolism. Thiamine pyrophosphate (TPP), a required cofactor for many enzymes in the cell, is synthesised de novo in Salmonella typhimurium.[1]
In Saccharomyces cerevisiae, hydroxyethylthiazole kinase expression is regulated at the mRNA level by intracellular thiamin pyrophosphate.[2]
As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes,,,,, and .