Hydroxycyclohexanecarboxylate dehydrogenase explained

hydroxycyclohexanecarboxylate dehydrogenase
Ec Number:	1.1.1.166
Cas Number:	55467-53-3
Go Code:	0047010

In enzymology, a hydroxycyclohexanecarboxylate dehydrogenase is an enzyme that catalyzes the chemical reaction

(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD⁺

\rightleftharpoons (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + NADH + H⁺

Thus, the two substrates of this enzyme are (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate and NAD⁺, whereas its 3 products are (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate:NAD⁺ 3-oxidoreductase. Other names in common use include dihydroxycyclohexanecarboxylate dehydrogenase, and (−)t-3,t-4-dihydroxycyclohexane-c-1-carboxylate-NAD⁺ oxidoreductase.

References

• Whiting GC, Coggins RA . 1974 . A new nicotinamide–adenine dinucleotide-dependent hydroaromatic dehydrogenase of Lactobacillus plantarum and its role in formation of (−)t-3t-4-dihydroxycyclohexane-c-1-carboxylate . Biochem. J. . 141 . 35 - 42 . 4375976 . 1 . 1168046 .