Hydroxychavicol Explained

Hydroxychavicol is a phenylpropanoid compound present in leaves of Piper betle.^[1] It is a more potent inhibitor of xanthine oxidase (IC₅₀=16.7 μM) than allopurinol.^{[2] [3]}

Research

It might be a useful new compound in treating cutaneous fungal infections.^[4] It is a promising agent in prevention and treatment of dental disorders as it had bactericidal and fungicidal effect on Streptococcus intermedius, Streptococcus mutans, and Candida albicans and inhibited biofilm formation.^{[5] [6] [7] [8]}

See also

• Chavicol

Notes and References

1. Atiya A, Sinha BN, Lal UR . The new ether derivative of phenylpropanoid and bioactivity was investigated from the leaves of Piper betle L . . 34 . 5 . 638–645 . March 2020 . 30169967 . 10.1080/14786419.2018.1495634 . 52139286 .
2. Murata K, Nakao K, Hirata N, Namba K, Nomi T, Kitamura Y, Moriyama K, Shintani T, Iinuma M, Matsuda H . Hydroxychavicol: a potent xanthine oxidase inhibitor obtained from the leaves of betel, Piper betle . . 63 . 3 . 355–9 . July 2009 . 19387769 . 10.1007/s11418-009-0331-y . 19647900 .
3. Nishiwaki K, Ohigashi K, Deguchi T, Murata K, Nakamura S, Matsuda H, Nakanishi I . Structure-Activity Relationships and Docking Studies of Hydroxychavicol and Its Analogs as Xanthine Oxidase Inhibitors . . 66 . 7 . 741–747 . July 2018 . 29695658 . 10.1248/cpb.c18-00197 . free .
4. Ali I, Satti NK, Dutt P, Prasad R, Khan IA . Hydroxychavicol: A phytochemical targeting cutaneous fungal infections . . 6 . 37867 . November 2016 . 27897199 . 5126685 . 10.1038/srep37867 . 2016NatSR...637867A .
5. Phumat P, Khongkhunthian S, Wanachantararak P, Okonogi S . Comparative inhibitory effects of 4-allylpyrocatechol isolated from Piper betle on Streptococcus intermedius, Streptococcus mutans, and Candida albicans . . 113 . 104690 . May 2020 . 32155466 . 10.1016/j.archoralbio.2020.104690 . 212664434 .
6. Ali. Intzar. Khan. Farrah G. Suri. Krishan A. Gupta. Bishan D. Satti. Naresh K. Dutt. Prabhu. Afrin. Farhat. Qazi. Ghulam N. Khan. Inshad A. In vitro antifungal activity of hydroxychavicol isolated from Piper betle L. Annals of Clinical Microbiology and Antimicrobials. 9. 1. 2010. 7. 1476-0711. 10.1186/1476-0711-9-7. 20128889 . 2841090 . free .
7. Himratul-Aznita. Wan Harun. Nor-Zulaila. Che Omran. Nurul-Fatihah. Khairuddin. Antifungal activity of dual combination of hydroxychavicol with commercialized agents against oral Candida species. SpringerPlus. 5. 1. 2016. 1696 . 2193-1801. 10.1186/s40064-016-3396-6. 27757368 . 5047859 . free .
8. Mail. Mohd Hafiz. Himratul-Aznita. Wan Harun. Musa. Md Yusoff. Anti-hyphal properties of potential bioactive compounds for oral rinse in suppression of Candida growth. Biotechnology & Biotechnological Equipment. 31. 5. 2017. 989–999. 1310-2818. 10.1080/13102818.2017.1348255. free.