Hydroquinone 1,2-dioxygenase explained

Hydroquinone 1,2-dioxygenase
Ec Number:	1.13.11.66

Hydroquinone 1,2-dioxygenase (hydroquinone dioxygenase) is an enzyme with systematic name benzene-1,4-diol:oxygen 1,2-oxidoreductase (decyclizing).^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

benzene-1,4-diol + O₂

\rightleftharpoons (2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoate

The enzyme is an extradiol-type dioxygenase. It belongs to the nonheme-iron(II)-dependent dioxygenase family.

Notes and References

1. Miyauchi K, Adachi Y, Nagata Y, Takagi M . Cloning and sequencing of a novel meta-cleavage dioxygenase gene whose product is involved in degradation of gamma-hexachlorocyclohexane in Sphingomonas paucimobilis . Journal of Bacteriology . 181 . 21 . 6712–9 . November 1999 . 10542173 . 94136 .
2. Moonen MJ, Synowsky SA, van den Berg WA, Westphal AH, Heck AJ, van den Heuvel RH, Fraaije MW, van Berkel WJ . Hydroquinone dioxygenase from pseudomonas fluorescens ACB: a novel member of the family of nonheme-iron(II)-dependent dioxygenases . Journal of Bacteriology . 190 . 15 . 5199–209 . August 2008 . 18502867 . 2493252 . 10.1128/JB.01945-07 .
3. Shen W, Liu W, Zhang J, Tao J, Deng H, Cao H, Cui Z . Cloning and characterization of a gene cluster involved in the catabolism of p-nitrophenol from Pseudomonas putida DLL-E4 . Bioresource Technology . 101 . 19 . 7516–22 . October 2010 . 20466541 . 10.1016/j.biortech.2010.04.052 .