Hydrophilization Explained

Hydrophilization is a process used on hydrophobic drugs to increase their release rate from capsules, which depends on the rate of dissolution, by covering the surfaces of their particles with minute droplets of a dissolved hydrophilic polymer (such as methyl cellulose or hydroxyethyl cellulose).[1] [2] In tablet or capsule formulations, this enhances the dissolution and disintegration of the drug.[2]

Notes and References

  1. Panraksa . Pattaraporn . Udomsom . Suruk . Rachtanapun . Pornchai . Chittasupho . Chuda . Ruksiriwanich . Warintorn . Jantrawut . Pensak . November 2020 . Hydroxypropyl Methylcellulose E15: A Hydrophilic Polymer for Fabrication of Orodispersible Film Using Syringe Extrusion 3D Printer . Polymers . en . 12 . 11 . 2666 . 10.3390/polym12112666 . free . 33198094 . 7696250 . 2073-4360.
  2. Lerk CF, Lagas M, Fell JT, Nauta P . Effect of hydrophilization of hydrophobic drugs on release rate from capsules . Journal of Pharmaceutical Sciences . 67 . 7 . 935–9 . July 1978 . 660511 . 10.1002/jps.2600670716.

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