Hydrogen dehydrogenase explained

hydrogen dehydrogenase
Ec Number:	1.12.1.2
Cas Number:	9027-05-8
Go Code:	0047985

In enzymology, a hydrogen dehydrogenase is an enzyme that catalyzes the chemical reaction

H₂ + NAD⁺

\rightleftharpoons H⁺ + NADH

Thus, the two substrates of this enzyme are H₂ and NAD⁺, whereas its two products are H⁺ and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on hydrogen as donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is hydrogen:NAD+ oxidoreductase. Other names in common use include H2:NAD+ oxidoreductase, NAD+-linked hydrogenase, bidirectional hydrogenase, and hydrogenase. This enzyme participates in glyoxylate and dicarboxylate metabolism and methane metabolism. It has 6 cofactors: FAD, Iron, FMN, Flavin, Nickel, and Iron-sulfur.

References

• BONE DH, BERNSTEIN S, VISHNIAC W . 1963 . Purification and some properties of different forms of hydrogen dehydrogenase . Biochim. Biophys. Acta . 67 . 581 - 8 . 13968752 . 10.1016/0006-3002(63)91868-7 .
• Schneider K, Schlegel HG . 1976 . Purification and properties of soluble hydrogenase from Alcaligenes eutrophus H 16 . Biochim. Biophys. Acta . 452 . 66 - 80 . 186126 . 1 . 10.1016/0005-2744(76)90058-9.