Hydrocortisone aceponate explained

See also: hydrocortisone.

Hydrocortisone aceponate is a veterinary corticosteroid that is used in form of creams for the treatment of various dermatoses (skin conditions).[1] It is an ester of hydrocortisone (cortisol) with acetic acid and propionic acid.

Medical Uses

Hydrocortisone aceponate is typically used for skin conditions in veterinary practices for dogs. In this instance, it can be used on acute otitis externa,[2] a bacterial infection causing inflammation of the ear canal, as well as a treatment for itchy skin caused by allergies.[3] Additionally, hydrocortisone aceponate can be used to treat hormonal disorders and immune and allergic disorders.[4] The main use for hydrocortisone aceponate is for atopic skin conditions and acute ear infections. It is shown to help with skin lesions and inflammation that respond to corticosteroids but may have been resistant to other treatments. It has been approved for veterinary use in the European Union.

Cortavance

Cortavance is the brand name for a veterinary drug used to treat inflamed, itchy skin, typically caused by allergies.

Easotic

Easotic is the brand name for a veterinary drug used to treat acute ear infections in dogs. The drug is composed of three active substances: hydrocortisone aceponate, miconazole nitrate and gentamicin. These are used in conjunction with hydrocortisone aceponate acts as an anti-inflammatory agent, miconazole nitrate has antifungal properties, and gentamicin is an antibiotic. The drug is used through ear drops and works to kill the foreign agent, prevent further spread, and mitigate symptoms.

Adverse effects

Side effects include:

Chemistry

Hydrocortisone aceponate is a steroid which takes the form of a diester. The diester increases transmission of the medicine through the skin and also increases the time that it remains in the affected area.[5]

Notes and References

  1. Mukhopadhyay AK, Baghel V . A study to evaluate the efficacy and safety of hydrocortisone aceponate 0.127% lipophilic cream in steroid responsive dermatoses in Indian patients . Indian Journal of Dermatology, Venereology and Leprology . 76 . 5 . 591 . 2010 . 20827017 . 10.4103/0378-6323.69093 . free.
  2. Web site: 24 February 2021. Easotic EPAR . European Medicines Agency (EMA).
  3. Web site: 24 September 2021. Cortavance EPAR . European Medicines Agency (EMA) .
  4. Web site: Hydrocortisone aceponate. 29 November 2021. DrugBank .
  5. Takahashi K, Sakano H, Numata N, Kuroda S, Mizuno N . Effect of fatty acid diesters on permeation of anti-inflammatory drugs through rat skin . Drug Development and Industrial Pharmacy . 28 . 10 . 1285–1294 . November 2002 . 12476874 . 10.1081/ddc-120015362 . 26471775 .