Human betaherpesvirus 6B explained

Human betaherpesvirus 6B (HHV-6B) is a species of virus in the genus Roseolovirus, subfamily Betaherpesvirinae, family Herpesviridae, and order Herpesvirales.[1]

Taxonomy

In 1992 the two variants were recognised within Human herpesvirus 6 on the basis of differing restriction endonuclease cleavages, monoclonal antibody reactions,[2] and growth patterns.[3] In 2012 these two variants were officially recognised as distinct species by the International Committee on Taxonomy of Viruses and named Human betaherpesvirus 6A and Human betaherpesvirus 6B.[4] Despite now being recognised as paraphyletic, the name Human herpesvirus 6 still sees usage in clinical contexts.

Pathology

See also: Human herpesvirus 6. Human betaherpesvirus 6B affects humans. Primary infection with this virus is the cause of the common childhood illness exanthema subitum (also known as roseola infantum or sixth disease). Additionally, reactivation is common in transplant recipients, which can cause several clinical manifestations such as encephalitis, bone marrow suppression, and pneumonitis.[5]

Notes and References

  1. Web site: ICTV Master Species List 2018b.v2. International Committee on Taxonomy of Viruses (ICTV). 19 June 2019.
  2. 10.1128/JVI.05622-11 . Analysis of a Neutralizing Antibody for Human Herpesvirus 6B Reveals a Role for Glycoprotein Q1 in Viral Entry . 2011 . Kawabata . A. . Oyaizu . H. . Maeki . T. . Tang . H. . Yamanishi . K. . Mori . Y. . Journal of Virology . 85 . 24 . 12962–71 . 21957287 . 3233151.
  3. 9227865 . 1997 . Braun . DK . Dominguez . G . Pellett . PE . Human herpesvirus 6 . 10 . 3 . 521–67 . 172933 . Clinical Microbiology Reviews. 10.1128/CMR.10.3.521 .
  4. Adams . M. J. . Carstens . E. B. . 10.1007/s00705-012-1299-6 . 7086667 . Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2012) . Archives of Virology . 157 . 7 . 1411–1422 . 2012 . 22481600 . free .
  5. 10.1046/j.1365-2141.2003.04788.x . Human herpesvirus 6 infection in hematopoietic stem cell transplant patients . 2004 . Yoshikawa . Tetsushi . British Journal of Haematology . 124 . 4 . 421–32 . 14984492. free .

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