Homospermidine synthase (spermidine-specific) explained

homospermidine synthase (spermidine-specific)
Ec Number:	2.5.1.45
Go Code:	0050514

In enzymology, a homospermidine synthase (spermidine-specific) is an enzyme that catalyzes the chemical reaction

spermidine + putrescine

\rightleftharpoons sym-homospermidine + propane-1,3-diamine

Thus, the two substrates of this enzyme are spermidine and putrescine, whereas its two products are sym-homospermidine and propane-1,3-diamine.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is spermidine:putrescine 4-aminobutyltransferase (propane-1,3-diamine-forming).

References

• Ostrovsky AN, Grischenko AV, Taylor PD, Bock P, Mawatari SF . 2006 . Comparative anatomical study of internal brooding in three anascan bryozoans (Cheilostomata) and its taxonomic and evolutionary implications . J. Morphol. . 267 . 739 - 49 . 16526057 . 10.1002/jmor.10438 . 6 . 13179435 . free .
• Ober D, Hartmann T . 1999 . Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved from deoxyhypusine synthase . Proc. Natl. Acad. Sci. U.S.A. . 96 . 14777 - 82 . 10611289 . 10.1073/pnas.96.26.14777 . 26 . 24724 . free .
• Ober D, Harms R, Hartmann T . 2000 . Cloning and expression of homospermidine synthase from Senecio vulgaris: a revision . . 55 . 311 - 316 . 11117877 . 10.1016/S0031-9422(00)00267-3 . 4.