Homophthalic acid explained

Homophthalic acid is a dicarboxylic acid with the formula C6H4(CO2H)CH2CO2H. It is a colorless solid. The compounds can be prepared by the Willgerodt reaction from 2-acetylbenzoic acid.[1]

One of the uses is in the preparation of the NSAID tesicam.

Notes and References

  1. 10.1021/jo01176a023. Preparation of Aryl Aliphatic Acids by the Modified Willgerodt Reaction. 1946. Schwenk. Erwin. Papa. Domenick. The Journal of Organic Chemistry. 11. 6. 798–802. 20282506.

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