HLA-DR6 explained

HLA-DR6 (DR6) is a broad-antigen serotype that is further split into HLA-DR13 and HLA-DR14 antigen serotypes.

Serology

DR13, DR6 and other serotype recognition of some DRB1*13 and DRB1*14 alleles^[1]

DRB1*	DR13	DR6	DR14	Sample
allele	%	%	%	size (N)
1301	81	14	1	3788
1302	74	17	2	3081
1303	69	10	2	948^[2]
1304	87			127
1305	54	12		305^[3]
1306	78			9
1307	>50			1
1308	45	55		9
1310	>75			5
DRB1*	DR14	DR6	DR13	N
1401	74	14	3	1942
1402	61	13	9	204
1403	72	12	2	37
1404	79	8		80^[4]
1405	86	10		58
1406	37	15	22	117
1407	90			10
1408	25			4^[5]
1410	>75			4

DR6 serological reactivity is relatively poor compared to other serological tests for DR antigens. Compare to DQ2 or DR7.

Disease associations

DR13 and DR14 share a common association to myasthenia gravis.^[6]

Allele groups

HLA-DRB1*13 and HLA-DRB1*14 encode serotypes of DR6.

Notes and References

1. http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA
2. DR12 - 3%, DR11 - 3% DR5-2%
3. DR12 - 6%, DR11 - 7% DR5-4%
4. DR1404 - 3%
5. DR4 - 25%
6. Shinomiya N, Nomura Y, Segawa M . A variant of childhood-onset myasthenia gravis: HLA typing and clinical characteristics in Japan. . Clin Immunol . 110 . 2 . 154–8 . 2004 . 15003812 . 10.1016/j.clim.2003.10.004.