HLA-DR5 explained

HLA-DR5 (DR5) is a broad-antigen serotype that is further split into HLA-DR11 and HLA-DR12 antigen serotypes.

Serology

DR11, DR5 and DR12 recognition of the gene products of some DRB1*11 and DRB1*12 alleles[1]
DRB1* DR11 DR5 DR12 Sample
allele % % % size (N)
11:01 92 5 3474
11:02 89 3 430
11:03 89 4 397
11:04 87 4 2119
11:05 75 4
11:06 20 73 15
11:07 >50 1
11:08 >50 2
11:09 80 20 5
.
DR12 DR5 DR11 Sample
12:01 83 4 2 893 [2]
12:02 89 162
12:03 >50 3
12:06 >50 2

Except for a few DRB1* alleles, the reactivity of DR5 is relatively poor.

Disease associations

DR5 is associated with persistent generalized lymphadenopathy[3] and Kaposi's sarcoma in AIDS,[4] juvenile rheumatoid arthritis,[5] [6] pernicious anemia, Hashimoto's thyroiditis,[7] [8] mycosis fungoides,[9] polyglandular deficiency syndrome,[10] systemic sclerosis,[11] [12] childhood epilepsy,[13] early-onset alopecia areata,[14] short-ragweed Ra6 allergy,[15] primary antiphospholipid syndrome,[16] and increased longevity in the Dutch.[17]

Genetic linkage

HLA-DR5 reactive gene products are linked to serology of HLA-DRB3 (HLA-DR52).

Notes and References

  1. http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA
  2. DR8 - 2%
  3. 10.1111/j.1399-0039.1987.tb01550.x . Raffoux C, David V, Couderc L, Rabian C, Clauvel J, Seligmann M, Colombani J . HLA-A, B and DR antigen frequencies in patients with AIDS-related persistent generalized lymphadenopathy (PGL) and thrombocytopenia. . Tissue Antigens . 29 . 1 . 60–2 . 1987 . 3495904.
  4. 10.1111/j.1399-0039.1983.tb00364.x . Pollack M, Safai B, Myskowski P, Gold J, Pandey J, Dupont B . Frequencies of HLA and Gm immunogenetic markers in Kaposi's sarcoma. . Tissue Antigens . 21 . 1 . 1–8 . 1983 . 6601312.
  5. Førre O, Dobloug J, Høyeraal H, Thorsby E . HLA antigens in juvenile arthritis. Genetic basis for the different subtypes. . Arthritis Rheum . 26 . 1 . 35–8 . 1983 . 6401993 . 10.1002/art.1780260106.
  6. Suciu-Foca N, Jacobs J, Godfrey M, Woodward K, Khan R, Reed E, Rohowsky C . HLA-DR5 in juvenile rheumatoid arthritis confined to few joints. . Lancet . 2 . 8184 . 40 . 1980 . 6104257 . 10.1016/S0140-6736(80)92920-7. 40329624 .
  7. 10.1111/j.1399-0039.1981.tb00700.x . Farid N, Sampson L, Moens H, Barnard J . The association of goitrous autoimmune thyroiditis with HLA-DR5. . Tissue Antigens . 17 . 3 . 265–8 . 1981 . 6947505.
  8. Schleusener H, Schernthaner G, Mayr W, Kotulla P, Bogner U, Finke R, Meinhold H, Koppenhagen K, Wenzel K . HLA-DR3 and HLA-DR5 associated thyrotoxicosis--two different types of toxic diffuse goiter. . J Clin Endocrinol Metab . 56 . 4 . 781–5 . 1983 . 6131902 . 10.1210/jcem-56-4-781.
  9. Safai B, Myskowski P, Dupont B, Pollack M . Association of HLA-DR5 with mycosis fungoides. . J Invest Dermatol . 80 . 5 . 395–7 . 1983 . 6601679 . 10.1111/1523-1747.ep12553615. free .
  10. Shapiro M, Zamir R, Weiss E, Radnay J, Shenkman L . The polyglandular deficiency syndrome: a new variant in Persian Jews. . J Endocrinol Invest . 10 . 1 . 1–7 . 1987 . 3496374 . 10.1007/bf03347139. 33773103 .
  11. Pereira S, Black C, Welsh K, Ansell B, Jayson M, Maddison P, Rowell N . Autoantibodies and immunogenetics in 30 patients with systemic sclerosis and their families. . J Rheumatol . 14 . 4 . 760–5 . 1987 . 3499513.
  12. Luderschmidt C, Scholz S, Mehlhaff E, König G, Albert E . Association of progressive systemic scleroderma to several HLA-B and HLA-DR alleles. . Arch Dermatol . 123 . 9 . 1188–91 . 1987 . 3498440 . 10.1001/archderm.123.9.1188.
  13. Minev M, Martinova F, Belopitova L . On the association of the HLA system with epilepsy in children. . Epilepsia . 28 . 1 . 74–6 . 1987. 3098558 . 10.1111/j.1528-1157.1987.tb03626.x. 12471018 .
  14. Orecchia G, Belvedere M, Martinetti M, Capelli E, Rabbiosi G . Human leukocyte antigen region involvement in the genetic predisposition to alopecia areata. . Dermatologica . 175 . 1 . 10–4 . 1987 . 3497062 . 10.1159/000248775.
  15. Marsh D, Freidhoff L, Ehrlich-Kautzky E, Bias W, Roebber M . Immune responsiveness to Ambrosia artemisiifolia (short ragweed) pollen allergen Amb a VI (Ra6) is associated with HLA-DR5 in allergic humans. . Immunogenetics . 26 . 4–5 . 230–6 . 1987 . 3498688 . 10.1007/BF00346517. 25679118 . free .
  16. Vargas-Alarcon G, Granados J, Bekker C, Alcocer-Varela J, Alarcón-Segovia D . Association of HLA-DR5 (possibly DRB1*1201) with the primary antiphospholipid syndrome in Mexican patients . Arthritis Rheum . 38 . 9 . 1340–1 . 1995 . 7575732 . 10.1002/art.1780380925. free .
  17. Lagaay A, D'Amaro J, Ligthart G, Schreuder G, van Rood J, Hijmans W . Longevity and heredity in humans. Association with the human leucocyte antigen phenotype . Ann N Y Acad Sci . 621 . 78–89 . 1991. 1859103 . 10.1111/j.1749-6632.1991.tb16970.x. 83560622 .

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