HLA-DR2 explained
HLA-DR2 (DR2) of the HLA-DR serotype system, is a broad antigen serotype that is now preferentially covered by HLA-DR15 and HLA-DR16 serotype group. This serotype primarily recognizes gene products of the HLA-DRB1*15 and HLA-DRB1*16 allele groups.
Serology
DR15, DR2 and other serotype recognition of some DRB1*15 alleles[1] | DRB1* | DR15 | DR2 | DR16 | Sample |
| allele | % | % | % | size (N) |
| 15:01 | 76 | 23 | | 6428 |
| 15:02 | 77 | 16 | | 676 |
| 15:03 | 81 | 13 | | 286 |
| 15:04 | >50 | | | 1 |
| 15:05 | >25 | | | 2 |
| 15:07 | >50 | | | 1 |
| | | | . |
| DR16 | DR2 | DR15 | N |
| 16:01 | 41 | 29 | 19 | 703 |
| 16:02 | 47 | 30 | 16 | 239 |
| 16:04 | >50 | | | 1 |
|
Disease associations
DR2 serotypes are associated with Goodpasture syndrome, systemic lupus erythematosus, multiple sclerosis,[2] narcolepsy, tuberculoid leprosy[3] (multi-drug-resistant tuberculosis or leprosy),[4] ulcerative colitis (Japanese),[5] primary biliary cirrhosis and autoimmune hepatitis.[6] DR2 is also found in all patients that test positive for anti-Asn-RNA-synthetase and chronic interstitial lung disease.[7]
Genetic linkage
DR2 is linked to the HLA-DR51.
Notes and References
- http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA
- Stewart G, McLeod J, Basten A, Bashir H . HLA family studies and multiple sclerosis: A common gene, dominantly expressed. . Hum Immunol . 3 . 1 . 13–29 . 1981 . 7275697 . 10.1016/0198-8859(81)90040-9.
- 10.1093/infdis/141.6.693 . van Eden W, de Vries R, Mehra N, Vaidya M, D'Amaro J, van Rood J . HLA segregation of tuberculoid leprosy: confirmation of the DR2 marker. . J Infect Dis . 141 . 6 . 693–701 . 1980 . 6156220.
- Singh M, Balamurugan A, Katoch K, Sharma SK, Mehra NK . Immunogenetics of mycobacterial infections in the North Indian population . Tissue Antigens . 69 . 228–30 . 2007 . Suppl 1 . 17445206 . 10.1111/j.1399-0039.2006.77311.x.
- Asakura H, Tsuchiya M, Aiso S, Watanabe M, Kobayashi K, Hibi T, Ando K, Takata H, Sekiguchi S . Association of the human lymphocyte-DR2 antigen with Japanese ulcerative colitis. . Gastroenterology . 82 . 3 . 413–8 . 1982 . 10.1016/S0016-5085(82)80387-9 . 6947923. free .
- Miyamori H, Kato Y, Kobayashi K, Hattori N . HLA antigens in Japanese patients with primary biliary cirrhosis and autoimmune hepatitis. . Digestion . 26 . 4 . 213–7 . 1983 . 6409699 . 10.1159/000198892.
- Hirakata M, Suwa A, Takada T, etal . Clinical and immunogenetic features of patients with autoantibodies to asparaginyl-transfer RNA synthetase . Arthritis Rheum. . 56 . 4 . 1295–303 . 2007 . 17393393 . 10.1002/art.22506. free .
