History of surgery explained

Surgery is the branch of medicine that deals with the physical manipulation of a bodily structure to diagnose, prevent, or cure an ailment. Ambroise Paré, a 16th-century French surgeon, stated that to perform surgery is, "To eliminate that which is superfluous, restore that which has been dislocated, separate that which has been united, join that which has been divided and repair the defects of nature."

Since humans first learned how to make and handle tools, they have employed their talents to develop surgical techniques, each time more sophisticated than the last; however, until the Industrial Revolution, surgeons were incapable of overcoming the three principal obstacles which had plagued the medical profession from its infancy—bleeding, pain and infection. Advances in these fields have transformed surgery from a risky "art" into a scientific discipline capable of treating many diseases and conditions.

Origins

The first surgical techniques were developed to treat injuries and traumas. A combination of archaeological and anthropological studies offer insight into much earlier techniques for suturing lacerations, amputating unsalvageable limbs, and draining and cauterizing open wounds. Many examples exist: some Asian tribes used a mix of saltpeter and sulfur that was placed onto wounds and lit on fire to cauterize wounds; the Dakota people used the quill of a feather attached to an animal bladder to suck out purulent material; the discovery of needles from the Stone Age seems to suggest they were used in the suturing of cuts (the Maasai used needles of acacia for the same purpose); and tribes in India and South America developed an ingenious method of sealing minor injuries by applying termites or scarabs who bit the edges of the wound and then twisted the insects' neck, leaving their heads rigidly attached like staples.[1]

Trepanation

The oldest operation for which evidence exists is trepanation[2] (also known as trepanning, trephination, trephining or burr hole from Greek τρύπανον and τρυπανισμός), in which a hole is drilled or scraped into the skull for exposing the dura mater to treat health problems related to intracranial pressure and other diseases. In the case of head wounds, surgical intervention was implemented for investigating and diagnosing the nature of the wound and the extent of the impact while bone splinters were removed preferably by scraping followed by post operation procedures and treatments for avoiding infection and aiding in the healing process.[3] [4] Evidence has been found in prehistoric human remains from Proto-Neolithic[5] and Neolithic times, in cave paintings, and the procedure continued in use well into recorded history (being described by ancient Greek writers such as Hippocrates). Out of 120 prehistoric skulls found at one burial site in France dated to 6500 BCE, 40 had trepanation holes.[6] Folke Henschen, a Swedish doctor and historian, asserts that Soviet excavations of the banks of the Dnieper River in the 1970s show the existence of trepanation in Mesolithic times dated to approximately 12000 BCE.[7] The remains suggest a belief that trepanning could cure epileptic seizures, migraines, and certain mental disorders.[8]

There is significant evidence of healing of the bones of the skull in prehistoric skeletons, suggesting that many of those that proceeded with the surgery survived their operation. In some studies, the rate of survival surpassed 50%.[9]

Amputation

The oldest known surgical amputation was carried out in Borneo about 31,000 years ago.[10] The operation involved the removal of the distal third of the left lower leg. The person survived the operation and lived for another 6 to 9 years. This is the only known surgical amputation carried out before the Neolithic Revolution and its farming transition. The next oldest known amputation was carried out about 7000 years ago on a farmer in France whose left forearm had been surgically removed.[11]

Setting bones

Examples of healed fractures in prehistoric human bones, suggesting setting and splinting have been found in the archeological record.[12] Among some treatments used by the Aztecs, according to Spanish texts during the conquest of Mexico, was the reduction of fractured bones: "...the broken bone had to be splinted, extended and adjusted, and if this was not sufficient an incision was made at the end of the bone, and a branch of fir was inserted into the cavity of the medulla..."[13] Modern medicine developed a technique similar to this in the 20th century known as medullary fixation.

Anesthesia

See main article: History of general anesthesia and History of tracheal intubation.

Bloodletting

Bloodletting is one of the oldest medical practices, having been practiced among diverse ancient peoples, including the Mesopotamians, the Egyptians, the Greeks, the Mayans, Indians and the Aztecs. In Greece, bloodletting was in use around the time of Hippocrates, who mentions bloodletting but in general relied on dietary techniques. Erasistratus, however, theorized that many diseases were caused by plethoras, or overabundances, in the blood, and advised that these plethoras be treated, initially, by exercise, sweating, reduced food intake, and vomiting. Herophilus advocated bloodletting. Archagathus, one of the first Greek physicians to practice in Rome, practiced bloodletting extensively. The art of bloodletting became very popular in the West, and during the Renaissance one could find bloodletting calendars that recommended appropriate times to bloodlet during the year and books that claimed bloodletting would cure inflammation, infections, strokes, manic psychosis and more.[14]

Antiquity

Mesopotamia

The Sumerians saw sickness as a divine punishment imposed by different demons when an individual broke a rule. For this reason, to be a physician, one had to learn to identify approximately 6,000 possible demons that might cause health problems. To do this, the Sumerians employed divining techniques based on the flight of birds, position of the stars and the livers of certain animals. In this way, medicine was intimately linked to priests, relegating surgery to a second-class medical specialty.[15]

Nevertheless, the Sumerians developed several important medical techniques: in Ninevah archaeologists have discovered bronze instruments with sharpened obsidian resembling modern day scalpels, knives, trephines, etc. The Code of Hammurabi, one of the earliest Babylonian code of laws, itself contains specific legislation regulating surgeons and medical compensation as well as malpractice and victim's compensation:[16]

Egypt

See also: Egyptian medical papyri. Around 3100 BCE Egyptian civilization began to flourish when Narmer, the first Pharaoh of Egypt, established the capital of Memphis. Just as cuneiform tablets preserved the knowledge of the ancient Sumerians, hieroglyphics preserved the Egyptians'.

In the first monarchic age (2700 BCE) the first treatise on surgery was written by Imhotep, the vizier of Pharaoh Djoser, priest, astronomer, physician and first notable architect. So much was he famed for his medical skill that he became the Egyptian god of medicine.[17] Other famous physicians from the Ancient Empire (from 2500 to 2100 BCE) were Sachmet, the physician of Pharaoh Sahure and Nesmenau, whose office resembled that of a medical director.

On one of the doorjambs of the entrance to the Temple of Memphis there is the oldest recorded engraving of a medical procedure: circumcision and engravings in Kom Ombo, Egypt depict surgical tools. Still of all the discoveries made in ancient Egypt, the most important discovery relating to ancient Egyptian knowledge of medicine is the Ebers Papyrus, named after its discoverer Georg Ebers.The Ebers Papyrus, conserved at the University of Leipzig, is considered one of the oldest treaties on medicine and the most important medical papyri. The text is dated to about 1550 BCE and measures 20 meters in length. The text includes recipes, a pharmacopoeia and descriptions of numerous diseases as well as cosmetic treatments. It mentions how to surgically treat crocodile bites and serious burns, recommending the drainage of pus-filled inflammation but warns against certain diseased skin.

Edwin Smith Papyrus

See main article: Edwin Smith Papyrus. The Edwin Smith Papyrus is a lesser known papyrus dating from the 1600 BCE and only 5 meters in length. It is a manual for performing traumatic surgery and gives 48 case histories.[12] [18] The Smith Papyrus describes a treatment for repairing a broken nose,[19] and the use of sutures to close wounds.[20] Infections were treated with honey.[21] For example, it gives instructions for dealing with a dislocated vertebra:

India

See also: List of Indian inventions and discoveries.

Mehrgarh

Teeth discovered from a Neolithic graveyard in Mehrgarh had shown signs of drilling.[22] Analysis of the teeth shows prehistoric people might have attempted curing toothache with drills made from flintheads.[23] [24]

Ayurveda

Sushruta (c. 600 BCE)[25] is considered as the "founding father of surgery". His period is usually placed between the period of 1200 BC – 600 BC.[26] One of the earliest known mention of the name is from the Bower Manuscript where Sushruta is listed as one of the ten sages residing in the Himalayas.[27] Texts also suggest that he learned surgery at Kasi from Lord Dhanvantari, the god of medicine in Hindu mythology.[28] He was an early innovator of plastic surgery who taught and practiced surgery on the banks of the Ganges in the area that corresponds to the present day city of Varanasi in Northern India. Much of what is known about Sushruta is in Sanskrit contained in a series of volumes he authored, which are collectively known as the Sushruta Samhita. It is one of the oldest known surgical texts and it describes in detail the examination, diagnosis, treatment, and prognosis of numerous ailments, as well as procedures on performing various forms of cosmetic surgery, plastic surgery and rhinoplasty.[29]

Greece and the Hellenized world

See also: Ancient Greek medicine, Medicine in ancient Rome and Surgery in Ancient Rome. Surgeons are now considered to be specialized physicians, whereas in the early ancient Greek world a trained general physician had to use his hands (χείρ in Greek) to carry out all medical and medicinal processes including, for example, the treating of wounds sustained on the battlefield, or the treatment of broken bones (a process called in Greek: χειρουργείν).

In The Iliad Homer names two doctors, “the two sons of Asklepios, the admirable physicians Podaleirius and Machaon and one acting doctor, Patroclus. Because Machaon is wounded and Podaleirius is in combat Eurypylus asks Patroclus “to cut out this arrow from my thigh, wash off the blood with warm water and spread soothing ointment on the wound."

Hippocrates

The Hippocratic Oath,[30] written in the 5th century BC provides the earliest protocol for professional conduct and ethical behavior a young physician needed to abide by in life and in treating and managing the health and privacy of his patients. The multiple volumes of the Hippocratic corpus[31] and the Hippocratic Oath elevated and separated the standards of proper Hippocratic medical conduct and its fundamental medical and surgical principles from other practitioners of folk medicine often laden with superstitious constructs, and/or of specialists of sorts some of whom would endeavor to carry out invasive body procedures with dubious consequences, such as lithotomy. Works from the Hippocratic corpus include; On the Articulations or On Joints, On Fractures, On the Instruments of Reduction, The Physician's Establishment or Surgery, On Injuries of the Head, On Ulcers, On Fistulae, and On Hemorrhoids.

Celsus and Alexandria

Herophilus of Chalcedon and Erasistratus of Ceos were two great Alexandrians who laid the foundations for the scientific study of anatomy and physiology.[32] Alexandrian surgeons were responsible for developments in ligature (hemostasis), lithotomy, hernia operations, ophthalmic surgery, plastic surgery, methods of reduction of dislocations and fractures, tracheotomy, and mandrake as anesthesia. Most of what we know of them comes from Celsus and Galen of Pergamum (Greek: Γαληνός)[33]

Galen

Galen's On the Natural Faculties, Books I, II, and III, is an excellent paradigm of a very accomplished Greek surgeon and physician of the 2nd century Roman era, who carried out very complex surgical operations and added significantly to the corpus of animal and human physiology and the art of surgery.[33] He was one of the first to use ligatures in his experiments on animals.[34] Galen is also known as "The king of the catgut suture"[35]

China

In China, instruments resembling surgical tools have also been found in the archaeological sites of Bronze Age dating from the Shang dynasty, along with seeds likely used for herbalism.[36]

Hua Tuo

Hua Tuo (140–208) was a famous Chinese physician during the Eastern Han and Three Kingdoms era. He was the first person to perform surgery with the aid of anesthesia, some 1600 years before the practice was adopted by Europeans.[37] Bian Que (Pien Ch'iao) was a "miracle doctor" described by the Chinese historian Sima Qian in his Shiji who was credited with many skills. Another book, Liezi (Lieh Tzu) describes that Bian Que conducted a two way exchange of hearts between people.[38] This account also credited Bian Que with using general anaesthesia which would place it far before Hua Tuo, but the source in Liezi is questioned and the author may have been compiling stories from other works.[39] Nonetheless, it establishes the concept of heart transplantation back to around 300 CE.

Middle Ages

Paul of Aegina's (c. 625 – c. 690 AD) Pragmateia or Compendiem was highly influential.[40] Abulcasis Al-Zahrawi of the Islamic Golden Age later repeated the material, largely verbatim.

Hunayn ibn Ishaq (809–873) was an Arab Nestorian Christian physician who translated many Greek medical and scientific texts, including those of Galen, writing the first systematic treatment of ophthalmology. Egypt-born Jewish physician Isaac Israeli ben Solomon (832–892) also left many medical works written in Arabic that were translated and adopted by European universities in the early 13th century.

The Persian physician Muhammad ibn Zakariya al-Razi (c. 865–925) advanced experimental medicine, pioneering ophthalmology and founding pediatrics. The Persian physician Ali ibn Abbas al-Majusi (d. 994) worked at the Al-Adudi Hospital in Baghdad, leaving The Complete Book of the Medical Art, which stressed the need for medical ethics and discussed the anatomy and physiology of the human brain. Persian physician Avicenna (980–1037) wrote The Canon of Medicine, a synthesis of Greek and Arab medicine that dominated European medicine until the mid-17th century.

In the 9th century the Medical School of Salerno in southwest Italy was founded, making use of Arabic texts and flourishing through the 13th century.

Abulcasis (936–1013) (Abu al-Qasim Khalaf ibn al-Abbas Al-Zahrawi) was an Andalusian-Arab physician and scientist who practised in the Zahra suburb of Cordoba. He is considered to be the greatest medieval surgeon, though he added little to Greek surgical practices. His works on surgery were highly influential.[41]

African-born Italian Benedictine monk (Muslim convert) Constantine the African (died 1099) of Monte Cassino translated many Arabic medical works into Latin.

Spanish Muslim physician Avenzoar (1094–1162) performed the first tracheotomy on a goat, writing Book of Simplification on Therapeutics and Diet, which became popular in Europe. Spanish Muslim physician Averroes (1126–1198) was the first to explain the function of the retina and to recognize acquired immunity with smallpox.

Universities such as Montpellier, Padua and Bologna were particularly renowned.

In the late 12th century Rogerius Salernitanus composed his Chirurgia, laying the foundation for modern Western surgical manuals. Roland of Parma and Surgery of the Four Masters were responsible for spreading Roger's work to Italy, France, and England. Roger seems to have been influenced more by the 6th-century Aëtius and Alexander of Tralles, and the 7th-century Paul of Aegina, than by the Arabs.[42] Hugh of Lucca (1150−1257) founded the Bologna School and rejected the theory of "laudable pus".

In the 13th century in Europe skilled town craftsmen called barber-surgeons performed amputations and set broken bones while suffering lower status than university educated doctors. By 1308 the Worshipful Company of Barbers in London was flourishing. With little or no formal training, they generally had a bad reputation that was not to improve until the development of academic surgery as a specialty of medicine rather than an accessory field in the 18th-century Age of Enlightenment.[43]

Guy de Chauliac (1298–1368) was one of the most eminent surgeons of the Middle Ages. His Chirurgia Magna or Great Surgery (1363) was a standard text for surgeons until well into the seventeenth century."[44]

Early modern Europe

There were some important advances to the art of surgery during this period. Andreas Vesalius (1514–1564), professor of anatomy at the University of Padua was a pivotal figure in the Renaissance transition from classical medicine and anatomy based on the works of Galen, to an empirical approach of 'hands-on' dissection. His anatomic treatise De humani corporis fabrica exposed many anatomical errors in Galen and advocated that all surgeons should train by engaging in practical dissections themselves.

The second figure of importance in this era was Ambroise Paré (sometimes spelled "Ambrose" (c. 1510 – 1590)[45]), a French army surgeon from the 1530s until his death in 1590. The practice for cauterizing gunshot wounds on the battlefield had been to use boiling oil, an extremely dangerous and painful procedure. Paré began to employ a less irritating emollient, made of egg yolk, rose oil and turpentine. He also described more efficient techniques for the effective ligation of the blood vessels during an amputation. In the same century, Eleno de Céspedes became perhaps the first female, transgender, or intersex surgeon in Spain, and perhaps in Europe.[46] [47] [48]

Another important early figure was German surgeon Wilhelm Fabry (1540–1634), "the Father of German Surgery", who was the first to recommend amputation above the gangrenous area, and to describe a windlass (twisting stick) tourniquet. His Swiss wife and assistant Marie Colinet (1560–1640) improved the techniques for Caesarean Section, introducing the use of heat for dilating and stimulating the uterus during labor. In 1624 she became the first to use a magnet to remove metal from a patient's eye, although he received the credit.

Modern surgery

Scientific surgery

The discipline of surgery was put on a sound, scientific footing during the Age of Enlightenment in Europe (1715–90). An important figure in this regard was the Scottish surgical scientist (in London) John Hunter (1728–1793), generally regarded as the father of modern scientific surgery.[49] He brought an empirical and experimental approach to the science and was renowned around Europe for the quality of his research and his written works. Hunter reconstructed surgical knowledge from scratch; refusing to rely on the testimonies of others he conducted his own surgical experiments to determine the truth of the matter. To aid comparative analysis, he built up a collection of over 13,000 specimens of separate organ systems, from the simplest plants and animals to humans.

Hunter greatly advanced knowledge of venereal disease and introduced many new techniques of surgery, including new methods for repairing damage to the Achilles tendon and a more effective method for applying ligature of the arteries in case of an aneurysm.[50] He was also one of the first to understand the importance of pathology, the danger of the spread of infection and how the problem of inflammation of the wound, bone lesions and even tuberculosis often undid any benefit that was gained from the intervention. He consequently adopted the position that all surgical procedures should be used only as a last resort.[51]

Hunter's student Benjamin Bell (1749–1806) became the first scientific surgeon in Scotland, advocating the routine use of opium in post-operative recovery, and counseling surgeons to "save skin" to speed healing; his great-grandson Joseph Bell (1837–1911) became the inspiration for Arthur Conan Doyle's literary hero Sherlock Holmes.

Other important 18th- and early 19th-century surgeons included Percival Pott (1714–1788), who first described tuberculosis of the spine and first demonstrated that a cancer may be caused by an environmental carcinogen after he noticed a connection between chimney sweep's exposure to soot and their high incidence of scrotal cancer. Astley Paston Cooper (1768–1841) first performed a successful ligation of the abdominal aorta. James Syme (1799–1870) pioneered the Symes Amputation for the ankle joint and successfully carried out the first hip disarticulation. Dutch surgeon Antonius Mathijsen invented the Plaster of Paris cast in 1851.

Anesthesia

Beginning in the 1840s, European surgery began to change dramatically in character with the discovery of effective and practical anesthetic chemicals such as ether, first used by the American surgeon Crawford Long (1815–1878), and chloroform, discovered by James Young Simpson (1811–1870) and later pioneered in England by John Snow (1813–1858), physician to Queen Victoria, who in 1853 administered chloroform to her during childbirth, and in 1854 disproved the miasma theory of contagion by tracing a cholera outbreak in London to an infected water pump.[52] In addition to relieving patient suffering, anaesthesia allowed more intricate operations in the internal regions of the human body. In addition, the discovery of muscle relaxants such as curare allowed for safer applications. American surgeon J. Marion Sims (1813–83) received credit for helping found gynecology, but later was criticized for failing to use anesthesia on enslaved Black test subjects.

Antiseptic surgery

The introduction of anesthetics encouraged more surgery, which inadvertently caused more dangerous patient post-operative infections. The first progress in combating infection in Europe was made in 1847 by the Hungarian doctor Ignaz Semmelweis who noticed that medical students fresh from the dissecting room were causing excess maternal death compared to midwives. Semmelweis, despite ridicule and opposition, introduced compulsory handwashing for everyone entering the maternal wards and was rewarded with a plunge in maternal and fetal deaths, however the Royal Society dismissed his advice.Until the pioneering work of British surgeon Joseph Lister in the 1860s, most medical men in Europe believed that chemical damage from exposures to bad air (see "miasma") was responsible for infections in wounds, and facilities for washing hands or a patient's wounds were not available.[53] Lister became aware of the work of French chemist and microbiology pioneer, Louis Pasteur, who showed that rotting and fermentation could occur under anaerobic conditions if micro-organisms were present. Pasteur suggested three methods to eliminate the micro-organisms responsible for gangrene: filtration, exposure to heat, or exposure to chemical solutions. Lister confirmed Pasteur's conclusions with his own experiments and decided to use his findings to develop antiseptic techniques for wounds. As the first two methods suggested by Pasteur were inappropriate for the treatment of human tissue, Lister experimented with the third, spraying carbolic acid on his instruments. He found that this remarkably reduced the incidence of gangrene and he published his results in The Lancet.[54] Later, on 9 August 1867, he read a paper before the British Medical Association in Dublin, on the Antiseptic Principle of the Practice of Surgery, which was reprinted in the British Medical Journal.[55] [56] [57] His work was groundbreaking and laid the foundations for a rapid advance in infection control that saw modern antiseptic operating theatres widely used within 50 years.

Lister continued to develop improved methods of antisepsis and asepsis when he realised that infection could be better avoided by preventing bacteria from getting into wounds in the first place. This led to the rise of sterile surgery. Lister instructed surgeons under his responsibility to wear clean gloves and wash their hands in 5% carbolic solution before and after operations, and had surgical instruments washed in the same solution.[58] He also introduced the steam steriliser to sterilize equipment. His discoveries paved the way for a dramatic expansion to the capabilities of the surgeon; for his contributions he is often regarded as the father of modern surgery.[59] These three crucial advances - the adoption of a scientific methodology toward surgical operations, the use of anaesthetic and the introduction of sterilised equipment - laid the groundwork for the modern invasive surgical techniques of today.

In the late 19th century William Stewart Halstead (1852–1922) laid out basic surgical principles for asepsis known as Halsteads principles. Halsted also introduced the latex medical glove. After one of his nurses suffered skin damage due to having to sterilize her hands with carbolic acid, Halsted had designed a rubber glove that could be dipped in carbolic acid.

X-rays

The use of X-rays as an important medical diagnostic tool began with their discovery in 1895 by German physicist Wilhelm Röntgen. He noticed that these rays could penetrate the skin, allowing the skeletal structure to be captured on a specially treated photographic plate.

Modern technologies

In the past century, a number of technologies have had a significant impact on surgical practice. These include Electrosurgery in the early 20th century, practical Endoscopy beginning in the 1960s, and Laser surgery, Computer-assisted surgery and Robotic surgery, developed in the 1980s.

Timeline of surgery and surgical procedures

Notable individuals in the development of surgery

See also: List of surgeons.

See also

Further reading

External links

Notes and References

  1. W. J. Bishop, The early history of Surgery. Hale, London, 1960
  2. (Capasso 2001)
  3. Agelarakis . Anagnostis P. . Early Evidence of Cranial Surgical Intervention in Abdera, Greece, a Nexus to On Head Wounds of the Hippocratic Corpus . Mediterranean Archaeology and Archaeometry . 6 . 1 . 2006 . 5–18 .
  4. Agelarakis . Anagnostis P. . Artful Surgery . Archaeology Magazine . 2006 . 59 . 2 .
  5. Ralph Solecki, Rose Solecki and Anagnostis Agelarakis, “The Proto-Neolithic Cemetery in Shanidar Cave”, Texas: A&M University Press, College Station, 2004
  6. Restak R (2000) Mysteries of the mind. National Geographic Society, Washington D.C.
  7. Book: Henschen . Folke . The human skull; a cultural history . 1966 . Praeger . New York . 579167145 .
  8. Book: Brothwell . Don R. . Digging Up Bones: The Excavation, Treatment and Study of Human Skeletal Remains . 1963 . British Museum . 126 . 1166993754 .
  9. La tribu Yanto en el Perú. Manuel Antonio Muñiz y W. J. Mc. Gree. In this study, 250 of 400 skulls showed evidence of surviving trepanation.
  10. 10.1038/s41586-022-05160-8 . Surgical amputation of a limb 600000 years ago in Borneo . 2022 . Maloney . Tim Ryan . Dilkes-Hall . India Ella . Vlok . Melandri . Oktaviana . Adhi Agus . Setiawan . Pindi . Priyatno . Andika Arief Drajat . Ririmasse . Marlon . Geria . I. Made . Effendy . Muslimin A. R. . Istiawan . Budi . Atmoko . Falentinus Triwijaya . Adhityatama . Shinatria . Moffat . Ian . Joannes-Boyau . Renaud . Brumm . Adam . Aubert . Maxime . Nature . 609 . 7927 . 547–551 . 36071168 . 9477728 . 2022Natur.609..547M .
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  14. http://ciruelo.uninorte.edu.co/pdf/salud_uninorte/16/1.la_sangria.pdf{{dead link|date=December 2014}}
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  24. News: McMahon . Barbara . Skeletons reveal secrets of 9,000-year-old dentistry . The Guardian . 17 April 2006 .
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  27. Kutumbian, pages XXXII-XXXIII
  28. [Monier-Williams]
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  31. Hippocrates, Vol. I-VIII, Loeb Classical Library, Harvard, 2004
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  33. Galen, On the Natural Faculties, Books I, II, and III, Loeb Classical Library, Harvard, 2000
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  47. Emilio Maganto Pavón, El proceso inquisitorial contra Elena/o de Céspedes. Biografía de una cirujana transexual del siglo XVI, Madrid, 2007.
  48. Francisco Vazquez Garcia, Sex, Identity and Hermaphrodites in Iberia, 1500–1800 (2015,), page 46.
  49. Book: Moore . Wendy . The Knife Man: The Extraordinary Life and Times of John Hunter, Father of Modern Surgery . 2005 . Broadway Books . 978-0-7679-1652-3 .
  50. Web site: John Hunter: "the father of scientific surgery": Resources from the collection of the P.I. Nixon Library. 2012-12-17. dead. https://web.archive.org/web/20131026210110/http://library.uthscsa.edu/2010/12/john-hunter-%E2%80%9Cthe-father-of-scientific-surgery%E2%80%9D-resources-from-the-collection-of-the-p-i-nixon-library/. 2013-10-26.
  51. Web site: John Hunter: 'Founder of Scientific Surgery' . 2012-12-17.
  52. Book: Gordon, H. Laing. Sir Orenthal James Simpson and Chloroform (1811–1870). 11 November 2011. November 2002. The Minerva Group, Inc.. 978-1-4102-0291-8. 108.
  53. Book: The Story Of Medicine . Kessinger Publishing . Robinson, Victor . June 2005 . 420 . 9781419154317 .
  54. Lister . Joseph . On a new method of treating compound fracture, abscess, etc.: with observations on the conditions of suppuration . The Lancet . March 1867 . 89 . 2272 . 326–329 . 10.1016/S0140-6736(02)51192-2 .
  55. 2310614. 2. 351. 245–260. The British Medical Journal. 21 September 1867. On the Antiseptic Principle in the Practice of Surgery. 20744875. Lister J. 10.1136/bmj.2.351.246. . Reprinted in 20361283. 2010. Lister. BJ. The classic: On the antiseptic principle in the practice of surgery. 1867. 468. 8. 2012–6. 10.1007/s11999-010-1320-x. 2895849. Clinical Orthopaedics and Related Research.
  56. Web site: Lister. Joseph. Modern History Sourcebook: Joseph Lister (1827–1912): Antiseptic Principle Of The Practice Of Surgery, 1867. Fordham University. 2 September 2011. Modernized version of text
  57. Book: Lister, Joseph. On the Antiseptic Principle of the Practice of Surgery by Baron Joseph Lister. Project Gutenberg. 2 September 2011. E-text, audio at Project Gutenberg.
  58. Metcalfe, Peter; Metcalfe, Roger (2006). Engineering Studies: Year 11. Glebe, N.S.W.: Pascal Press. p. 151. . Retrieved 2014-07-07.
  59. Book: Truax . Rhoda . Joseph Lister: Father of Modern Surgery . 2010 . Kessinger Publishing . 978-1-164-49957-2 .
  60. Book: Silverberg, Robert. The dawn of medicine. registration. 1 December 2012. 1967. Putnam.
  61. Book: O'Connor. Stephen. Corner. Jessica. Bailey. Christopher. Cancer Nursing Care in Context. 2009. John Wiley & Sons. Chichester. 9781444309256. 218. 2nd. Chapter 11: Surgery.
  62. 10.1056/NEJMc0900837. Renal Transplantation between HIV-Positive Donors and Recipients . 2010 . Muller . Elmi . Kahn . Delawir . Mendelson . Marc . New England Journal of Medicine . 362 . 24 . 2336–2337 . 20554994 . 5094174 .
  63. 8 Facts About How Penis Transplants Work . Time . 16 May 2016 .
  64. Book: Chauliac). Guy (de. McVaugh. M. R. (Michael Rogers). Inventarium sive chirugia magna. 7 December 2012. 1997. BRILL. 9789004107847.
  65. Book: Arderne. John. Millar. Eric. De arte phisicali et de cirurgia of Master John Arderne, sugreon of Newark, dated 1412. 7 December 2012. 1922. W. Wood.
  66. Book: Arderne, John. Treatises of Fistula in Ano, Hemorrhoids, and Clysters. 7 December 2012. 1999-01-01. Elibron.com. 9781402196805.
  67. Book: Benivieni. Antonio. Polybus. Guinterius. Joannes. De abditis nonnullis ac mirandis morborum & sanationum causis. 7 December 2012. 1529. apud Andream Cratandrum.
  68. Book: Thorndike, Lynn. A History of Magic and Experimental Science: Fourteenth and fifteenth centuries. 7 December 2012. 1958. Columbia University Press. 9780231087971.
  69. Book: Pagel, Walter. Paracelsus: An Introduction to Philosophical Medicine in the Era of the Renaissance. 7 December 2012. 1958. Karger Publishers. 9783805535182. 15–.
  70. Book: Crone, Hugh D.. Paracelsus: The Man who Defied Medicine : His Real Contribution to Medicine and Science. 7 December 2012. 2004-05-01. Albarello Press. 9780646433271. 104.
  71. Book: Paget, Stephen. Ambroise Paré and his times, 1510–1590. 7 December 2012. 1897. G.P. Putnam's sons.
  72. Book: Paré. Ambroise. Spiegel. Adriaan van den. The Workes of that Famous Chirurgion Ambrose Parey. 7 December 2012. 1649. R. Cotes and Willi Du-gard, and are to be sold by John Clarke.
  73. Book: M.D., Frederic S. Dennis. System of Surgery. 7 December 2012. 1895. 56–57.
  74. Book: McCallum, Jack E.. Military Medicine: From Ancient Times to the 21st Century. 7 December 2012. 2008-02-01. ABC-CLIO. 9781851096930.
  75. Book: Norton, Jeffrey A.. Surgery: Basic Science and Clinical Evidence. 7 December 2012. 2008-01-01. Springer. 9780387681139.
  76. Book: Ellis, Harold. A History Of Surgery. 7 December 2012. 2001. Cambridge University Press. 9781841101811. 47.
  77. Book: Finlayson, James. James Finlayson (surgeon). Account of the life and works of Maister Peter Lowe: the founder of the Faculty of Physicians and Surgeons of Glasgow. 7 December 2012. 1889. J. Maclehose.
  78. Book: Longmore, Sir Thomas. Richard Wiseman, surgeon and sergeant-surgeon to Charles II.: A biographical study. 7 December 2012. 1891. Longmans, Green and co..
  79. Book: Wiseman, Richard. Eight chirurgical treatises, on these following heads: viz. I. Of tumours. II. Of ulcers. III. Of diseases of the anus. IV. Of the king's evil. V. Of wounds. VI. Of gun-shot wounds. VII. Of fractures and luxations. VIII. Of the lues venerea. 7 December 2012. 1734. J. Walthoe.
  80. Book: Houstoun. Robert. Cheselden. William. Arbuthnot. John. Lithotomus castratus; or Mr. Cheselden's Treatise on the high operation for the stone: thoroughly examin'd and plainly found to be Lithotomia Douglassiana, under another title: in a letter to Dr. John Arbuthnot. With an appendix, wherein both authors are fairly compar'd. 7 December 2012. 1723. T. Payne.
  81. Book: Cheselden, William. Anatomical Tables of the Human Body. by William Cheselden, Surgeon to His Majesty's Royal Hospital at Chelsea, Fellow of the Royal Society, and Member. 7 December 2012. 2010-06-10. BiblioBazaar. 9781170888018.
  82. Book: Dran, Henri-François Le. The operations in surgery. 7 December 2012. 1768. printed for Hawes Clarke and Collins, J. Dodsley, W. Johnston, B. Law and T. Becket.
  83. Book: Heister, Lorenz. A General System of Surgery: In Three Parts .... 7 December 2012. 1763. J. Clarke, [etc.].
  84. Book: Pott. Percivall. (Sir.). James Earles. The chirurgical works of Percival Pott ...: to which are added a short account of the life of the author, a method of curing the hydrocele by injection and occasional notes and observations by Sir James Earle. 7 December 2012. 1808. J. Johnson.
  85. Book: Pott. Percivall. Earle. Sir James. The chirurgical works of Percivall Pott: with his last corrections. 7 December 2012. 1819. Published by James Webster; William Brown, printer.
  86. Book: Mostof, Seyed Behrooz. Who's Who in Orthopedics. 7 December 2012. 2005-01-01. Springer. 9781846280702. 278.
  87. Book: International Journal of Surgery: Devoted to the Theory and Practice of Modern Surgery and Gynecology. 1919. The International Journal of Surgery Co.. 392.
  88. Book: Paget, Stephen. John Hunter, man of science and surgeon (1728–1793). 7 December 2012. 1897. T. Fisher Unwin.
  89. Book: Moore, Wendy. The Knife Man: The Extraordinary Life and Times of John Hunter, Father of Modern Surgery. 7 December 2012. 2005-09-13. Random House Digital, Inc.. 9780767916523.
  90. Book: London. Hunterian Museum. curator.). Elizabeth Allen (George Qvist. England. Royal College of Surgeons of. A guide to the Hunterian Museum: John Hunter, 1728–1793. 7 December 2012. 1993. Royal College of Surgeons of England.
  91. Book: Desault, Pierre-Joseph. Parisian Chirurgical Journal. 7 December 2012. 1794. Printed for the translator.
  92. Book: Porter, Roy. The Cambridge Illustrated History of Medicine. 7 December 2012. 2001-07-30. Cambridge University Press. 9780521002523. 221.
  93. Book: M.D.. Ann M. Berger. Shuster. John L.. M.D.. Jamie H. Von Roenn. Principles and Practice of Palliative Care and Supportive Oncology, 3e. 7 December 2012. 2007. Lippincott Williams & Wilkins. 9780781795951. 322.
  94. Book: Larrey, baron Dominique Jean. Memoirs of Military Surgery, and Campaigns of the French Armies, on the Rhine, in Corsica, Catalonia, Egypt, and Syria; at Boulogne, Ulm, and Austerlitz; in Saxony, Prussia, Poland, Spain, and Austria. 7 December 2012. 1814. Joseph Cushing, 6, North Howard street.
  95. Book: (baron). Dominique Jean Larrey. Waller. John Augustine. Memoirs of military surgery: Containing the practice of the French military surgeons during the principal campaigns of the late war. Abridged and translated from the French by John Waller. In two parts. 7 December 2012. 1815. Cox.
  96. Book: (baron), Dominique Jean Larrey. Memoir of Baron Larrey, surgeon-in-chief of the Grande Armée, from the French. 7 December 2012. 1861. H. Renshaw.
  97. Book: Kingsnorth. Andrew N.. Majid. Aljafri A.. Fundamentals of Surgical Practice. 7 December 2012. 2006. Cambridge University Press. 9780521677066. 265.
  98. Book: Scarpa, Antonio. A treatise on the anatomy, pathology and surgical treatment of aneurism, with engravings. 7 December 2012. 1808. Printed for Mundell, Doig, & Stevenson.
  99. Book: bart.), Astley Paston Cooper (sir), 1st. The lectures of sir Astley Cooper, bart ... on the principles and practice of surgery, with additional notes and cases, by F. Tyrrell. 7 December 2012. 1824.
  100. Book: Cooper. Sir Astley. Green. Joseph Henry. A manual of surgery: founded upon the principles and practice lately taught by Sir Astley Cooper ... and Joseph Henry Green .... 7 December 2012. 1832. Printed for E. Cox.
  101. Book: Bell, Benjamin. A System of Surgery. by Benjamin Bell, ... Illustrated with Copperplates. ... the Fifth Edition. Volume 6 of 6 . 7 December 2012. May 2010. BiblioLife. 9781140774365.
  102. Book: Garrison, Fielding Hudson. An Introduction to the history of medicine. 7 December 2012. 1921. W.B. Saunders Company. 508–.
  103. Book: Bell. John. Bell. Sir Charles. Godman. John Davidson. The anatomy and physiology of the human body. 7 December 2012. 1827. Collins & co..
  104. Book: Bell, John. The principles of surgery. 7 December 2012. 1808. Printed for Longman, Hurst, Rees and Orme.
  105. Book: Eaton. Charles. Seegenschmiedt. M. Heinrich. Bayat. Ardeshir . Giulio Gabbiani . Paul Werker . Wolfgang Wach. Dupuytren's Disease and Related Hyperproliferative Disorders: Principles, Research, and Clinical Perspectives. 7 December 2012. 2012-03-20. Springer. 9783642226960. 200–.
  106. Book: Wylock, Paul. The Life and Times of Guillaume Dupuytren, 1777–1835. 7 December 2012. 2010-09-01. Asp / Vubpress / Upa. 9789054875727.
  107. Book: Dupuytren, Guillaume. On the injuries and diseases of bones. 7 December 2012. 1847. Sydenham Society.
  108. Book: Rutkow, Ira M.. History of Surgery in the United States 1775–1900: Periodical and Pamphlet Literature. 7 December 2012. 1992. Norman Publishing. 9780930405489. 98–.
  109. Book: Sims, James Marion. Clinical notes on uterine surgery c. 3. 7 December 2012. 1886. William Wood.
  110. Book: Sims, James Marion. The story of my life. 7 December 2012. 1888. D. Appleton and Company.

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