HDAC1 explained

Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene.^[1]

Function

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2 MTA2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.^[2]

Interactions

HDAC1 has been shown to interact with:

• Androgen receptor,^[3]
• BCL6,^[4]
• BTG2,^{[5] [6]}
• BUB1B,
• BUB1,
• BUB3,
• CBFA2T3,^{[7] [8]}
• CDC20,^[9]
• CDH1,^[9]
• CHD3,
• CHD4,
• COUP-TFII,^[10]
• CTBP1,^{[11] [12]}
• DDX17,
• DDX5,^[13]
• DNMT3A,^[14]
• DNMT3L,^{[15] [16]}
• Death-associated protein 6,^[17]
• EED,
• EVI1,^{[18] [19]}
• EZH2,
• FKBP3,^[20]
• GATA1,^[21]
• HMG20B,
• HSPA4,
• HUS1,
• Histone deacetylase 2,^{[22] [23] [24] [25] [26] [27] [28] [29] [30] [31] [32]}
• Homeobox protein TGIF1,^{[33] [34]}
• Host cell factor C1,^[35]
• IFRD1,^[36]
• IKZF1,^{[37] [38]}
• ING1,^[39]
• MBD3,^{[30] [40] [41]}
• MIER1,^[42]
• MLL,^[43]
• MTA1,^{[44] [45]}
• MTA2,^{[44] [30]}
• Mad1,^[9]
• Mdm2,^[46]
• Methyl-CpG-binding domain protein 2,^{[30] [47]}
• Mothers against decapentaplegic homolog 2,^[48]
• MyoD,^{[49] [50]}
• NFKB1,
• Nuclear receptor co-repressor 2,^{[51] [52]}
• P21,^[53]
• PCNA,^[54]
• PHF21A,^{[24] [55]}
• Prohibitin,^{[56] [57]}
• Promyelocytic leukemia protein,^{[58] [59]}
• RAD9A,^[60]
• RBBP4,^{[44] [30] [31] [32] [61] [62]}
• RBBP7,^{[44] [30] [32] [63]}
• RCOR1,^[24]
• RELA,^{[29] [64] [65]}
• RFC1,^[66]
• Retinoblastoma protein,^{[49] [57] [67] [68] [69]}
• Retinoblastoma-like protein 1,^[70]
• Retinoblastoma-like protein 2,^{[71] [72]}
• SAP30,^{[30] [73] [74] [75] [76]}
• SATB1,
• SIN3A,^{[22] [77] [44] [78] [30] [31] [79] [80] [81] [82] [83] [84] [85] [86]}
• SIN3B,^{[30] [37]}
• SPEN,^[87]
• SUDS3,^{[83] [88]}
• SUV39H1,^[89]
• Sp1 transcription factor,^{[82] [90] [91] [92]}
• TOP2A,
• TOP2B,^{[93] [94]} and
• Zinc finger and BTB domain-containing protein 16.^{[95] [96] [97]}

See also

• Histone deacetylase
• Histone deacetylase inhibitor

Further reading

• Wolffe AP . Histone deacetylase: a regulator of transcription . Science . 272 . 5260 . 371–2 . April 1996 . 8602525 . 10.1126/science.272.5260.371 . 1996Sci...272..371W . 27257723 .
• Ahringer J . NuRD and SIN3 histone deacetylase complexes in development . Trends in Genetics . 16 . 8 . 351–6 . August 2000 . 10904264 . 10.1016/S0168-9525(00)02066-7 .
• Verdin E, Dequiedt F, Kasler HG . Class II histone deacetylases: versatile regulators . Trends in Genetics . 19 . 5 . 286–93 . May 2003 . 12711221 . 10.1016/S0168-9525(03)00073-8 . 2268/80861 . free .
• Zhang Y, Dufau ML . Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes . The Journal of Steroid Biochemistry and Molecular Biology . 85 . 2–5 . 401–14 . June 2003 . 12943729 . 10.1016/S0960-0760(03)00230-9 . 28512341 .
• Stevens M, De Clercq E, Balzarini J . The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention . Medicinal Research Reviews . 26 . 5 . 595–625 . September 2006 . 16838299 . 10.1002/med.20081 . 7168390 .
• Hijmans EM, Voorhoeve PM, Beijersbergen RL, van 't Veer LJ, Bernards R . E2F-5, a new E2F family member that interacts with p130 in vivo . Molecular and Cellular Biology . 15 . 6 . 3082–9 . June 1995 . 7760804 . 230539 . 10.1128/mcb.15.6.3082 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Margolis DM, Somasundaran M, Green MR . Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production . Journal of Virology . 68 . 2 . 905–10 . February 1994 . 10.1128/JVI.68.2.905-910.1994 . 8289393 . 236527 .
• Furukawa Y, Kawakami T, Sudo K, Inazawa J, Matsumine A, Akiyama T, Nakamura Y . Isolation and mapping of a human gene (RPD3L1) that is homologous to RPD3, a transcription factor in Saccharomyces cerevisiae . Cytogenetics and Cell Genetics . 73 . 1–2 . 130–3 . 1996 . 8646880 . 10.1159/000134323 .
• Hassig CA, Fleischer TC, Billin AN, Schreiber SL, Ayer DE . Histone deacetylase activity is required for full transcriptional repression by mSin3A . Cell . 89 . 3 . 341–7 . May 1997 . 9150133 . 10.1016/S0092-8674(00)80214-7 . 14233219 . free .
• Laherty CD, Yang WM, Sun JM, Davie JR, Seto E, Eisenman RN . Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression . Cell . 89 . 3 . 349–56 . May 1997 . 9150134 . 10.1016/S0092-8674(00)80215-9 . 13490886 . free .
• Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D . Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex . Cell . 89 . 3 . 357–64 . May 1997 . 9150135 . 10.1016/S0092-8674(00)80216-0 . free .
• Romerio F, Gabriel MN, Margolis DM . Repression of human immunodeficiency virus type 1 through the novel cooperation of human factors YY1 and LSF . Journal of Virology . 71 . 12 . 9375–82 . December 1997 . 10.1128/JVI.71.12.9375-9382.1997 . 9371597 . 230241 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Brehm A, Miska EA, McCance DJ, Reid JL, Bannister AJ, Kouzarides T . Retinoblastoma protein recruits histone deacetylase to repress transcription . Nature . 391 . 6667 . 597–601 . February 1998 . 9468139 . 10.1038/35404 . 1998Natur.391..597B . 4326464 .
• Magnaghi-Jaulin L, Groisman R, Naguibneva I, Robin P, Lorain S, Le Villain JP, Troalen F, Trouche D, Harel-Bellan A . Retinoblastoma protein represses transcription by recruiting a histone deacetylase . Nature . 391 . 6667 . 601–5 . February 1998 . 9468140 . 10.1038/35410 . 1998Natur.391..601M . 4315457 .
• Lin RJ, Nagy L, Inoue S, Shao W, Miller WH, Evans RM . Role of the histone deacetylase complex in acute promyelocytic leukaemia . Nature . 391 . 6669 . 811–4 . February 1998 . 9486654 . 10.1038/35895 . 1998Natur.391..811L . 4383951 . free .
• Luo RX, Postigo AA, Dean DC . Rb interacts with histone deacetylase to repress transcription . Cell . 92 . 4 . 463–73 . February 1998 . 9491888 . 10.1016/S0092-8674(00)80940-X . 18857544 . free .

Notes and References

1. Taunton J, Hassig CA, Schreiber SL . A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p . Science . 272 . 5260 . 408–11 . April 1996 . 8602529 . 10.1126/science.272.5260.408 . 1996Sci...272..408T . 25717734 .
2. Web site: Entrez Gene: HDAC1 histone deacetylase 1.
3. Gaughan L, Logan IR, Cook S, Neal DE, Robson CN . Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor . The Journal of Biological Chemistry . 277 . 29 . 25904–13 . July 2002 . 11994312 . 10.1074/jbc.M203423200 . free .
4. Deltour S, Guerardel C, Leprince D . Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B . Proceedings of the National Academy of Sciences of the United States of America . 96 . 26 . 14831–6 . December 1999 . 10611298 . 24733 . 10.1073/pnas.96.26.14831 . 1999PNAS...9614831D . free .
5. Farioli-Vecchioli S, Tanori M, Micheli L, Mancuso M, Leonardi L, Saran A, Ciotti MT, Ferretti E, Gulino A, Pazzaglia S, Tirone F . Inhibition of medulloblastoma tumorigenesis by the antiproliferative and pro-differentiative gene PC3 . FASEB Journal . 21 . 9 . 2215–25 . July 2007 . 17371797 . 10.1096/fj.06-7548com . 4974360 . free .
6. Micheli L, D'Andrea G, Leonardi L, Tirone F . HDAC1, HDAC4, and HDAC9 Bind to PC3/Tis21/Btg2 and Are Required for Its Inhibition of Cell Cycle Progression and Cyclin D1 Expression . Journal of Cellular Physiology . 232 . 7 . 1696–1707 . July 2017 . 27333946 . 10.1002/jcp.25467 . 4070837 .
7. Hoogeveen AT, Rossetti S, Stoyanova V, Schonkeren J, Fenaroli A, Schiaffonati L, van Unen L, Sacchi N . The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies . Oncogene . 21 . 43 . 6703–12 . September 2002 . 12242670 . 10.1038/sj.onc.1205882 . 19634011 .
8. Amann JM, Nip J, Strom DK, Lutterbach B, Harada H, Lenny N, Downing JR, Meyers S, Hiebert SW . ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain . Molecular and Cellular Biology . 21 . 19 . 6470–83 . October 2001 . 11533236 . 99794 . 10.1128/mcb.21.19.6470-6483.2001 .
9. Yoon YM, Baek KH, Jeong SJ, Shin HJ, Ha GH, Jeon AH, Hwang SG, Chun JS, Lee CW . WD repeat-containing mitotic checkpoint proteins act as transcriptional repressors during interphase . FEBS Letters . 575 . 1–3 . 23–9 . September 2004 . 15388328 . 10.1016/j.febslet.2004.07.089 . 21762011 . free .
10. Smirnov DA, Hou S, Ricciardi RP . Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription . Virology . 268 . 2 . 319–28 . March 2000 . 10704340 . 10.1006/viro.1999.0181 . free .
11. Zhang CL, McKinsey TA, Lu JR, Olson EN . Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor . The Journal of Biological Chemistry . 276 . 1 . 35–9 . January 2001 . 11022042 . 10.1074/jbc.M007364200 . free .
12. Sundqvist A, Sollerbrant K, Svensson C . The carboxy-terminal region of adenovirus E1A activates transcription through targeting of a C-terminal binding protein-histone deacetylase complex . FEBS Letters . 429 . 2 . 183–8 . June 1998 . 9650586 . 10.1016/s0014-5793(98)00588-2 . 20660291 .
13. Wilson BJ, Bates GJ, Nicol SM, Gregory DJ, Perkins ND, Fuller-Pace FV . The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner . BMC Molecular Biology . 5 . 11 . August 2004 . 15298701 . 514542 . 10.1186/1471-2199-5-11 . free .
14. Fuks F, Burgers WA, Godin N, Kasai M, Kouzarides T . Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription . The EMBO Journal . 20 . 10 . 2536–44 . May 2001 . 11350943 . 125250 . 10.1093/emboj/20.10.2536 .
15. Aapola U, Liiv I, Peterson P . Imprinting regulator DNMT3L is a transcriptional repressor associated with histone deacetylase activity . Nucleic Acids Research . 30 . 16 . 3602–8 . August 2002 . 12177302 . 134241 . 10.1093/nar/gkf474 .
16. Deplus R, Brenner C, Burgers WA, Putmans P, Kouzarides T, de Launoit Y, Fuks F . Dnmt3L is a transcriptional repressor that recruits histone deacetylase . Nucleic Acids Research . 30 . 17 . 3831–8 . September 2002 . 12202768 . 137431 . 10.1093/nar/gkf509 .
17. Li H, Leo C, Zhu J, Wu X, O'Neil J, Park EJ, Chen JD . Sequestration and inhibition of Daxx-mediated transcriptional repression by PML . Molecular and Cellular Biology . 20 . 5 . 1784–96 . March 2000 . 10669754 . 85360 . 10.1128/mcb.20.5.1784-1796.2000 .
18. Vinatzer U, Taplick J, Seiser C, Fonatsch C, Wieser R . The leukaemia-associated transcription factors EVI-1 and MDS1/EVI1 repress transcription and interact with histone deacetylase . British Journal of Haematology . 114 . 3 . 566–73 . September 2001 . 11552981 . 10.1046/j.1365-2141.2001.02987.x . 7643309 .
19. Chakraborty S, Senyuk V, Sitailo S, Chi Y, Nucifora G . Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles . The Journal of Biological Chemistry . 276 . 48 . 44936–43 . November 2001 . 11568182 . 10.1074/jbc.M106733200 . free .
20. Yang WM, Yao YL, Seto E . The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1 . The EMBO Journal . 20 . 17 . 4814–25 . September 2001 . 11532945 . 125595 . 10.1093/emboj/20.17.4814 .
21. Watamoto K, Towatari M, Ozawa Y, Miyata Y, Okamoto M, Abe A, Naoe T, Saito H . Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation . Oncogene . 22 . 57 . 9176–84 . December 2003 . 14668799 . 10.1038/sj.onc.1206902 . 24491249 .
22. Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL . Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex . Nature . 395 . 6705 . 917–21 . October 1998 . 9804427 . 10.1038/27699 . 1998Natur.395..917T . 4355885 .
23. van der Vlag J, Otte AP . Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation . Nature Genetics . 23 . 4 . 474–8 . December 1999 . 10581039 . 10.1038/70602 . 6748531 .
24. Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R . A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes . Proceedings of the National Academy of Sciences of the United States of America . 99 . 11 . 7420–5 . May 2002 . 12032298 . 124246 . 10.1073/pnas.112008599 . 2002PNAS...99.7420H . free .
25. Johnson CA, White DA, Lavender JS, O'Neill LP, Turner BM . Human class I histone deacetylase complexes show enhanced catalytic activity in the presence of ATP and co-immunoprecipitate with the ATP-dependent chaperone protein Hsp70 . The Journal of Biological Chemistry . 277 . 11 . 9590–7 . March 2002 . 11777905 . 10.1074/jbc.M107942200 . free.
26. Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R . A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes . The Journal of Biological Chemistry . 278 . 9 . 7234–9 . February 2003 . 12493763 . 10.1074/jbc.M208992200 . free.
27. Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E . Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR . Molecular Cell . 9 . 1 . 45–57 . January 2002 . 11804585 . 10.1016/s1097-2765(01)00429-4 . 11858/00-001M-0000-002C-9FF7-D . free .
28. Fischle W, Dequiedt F, Fillion M, Hendzel MJ, Voelter W, Verdin E . Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo . The Journal of Biological Chemistry . 276 . 38 . 35826–35 . September 2001 . 11466315 . 10.1074/jbc.M104935200 . free .
29. Ashburner BP, Westerheide SD, Baldwin AS . The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression . Molecular and Cellular Biology . 21 . 20 . 7065–77 . October 2001 . 11564889 . 99882 . 10.1128/MCB.21.20.7065-7077.2001 .
30. Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D . Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation . Genes & Development . 13 . 15 . 1924–35 . August 1999 . 10444591 . 316920 . 10.1101/gad.13.15.1924 .
31. Hassig CA, Tong JK, Fleischer TC, Owa T, Grable PG, Ayer DE, Schreiber SL . A role for histone deacetylase activity in HDAC1-mediated transcriptional repression . Proceedings of the National Academy of Sciences of the United States of America . 95 . 7 . 3519–24 . March 1998 . 9520398 . 19868 . 10.1073/pnas.95.7.3519 . 1998PNAS...95.3519H . free .
32. Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D . Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex . Cell . 89 . 3 . 357–64 . May 1997 . 9150135 . 10.1016/s0092-8674(00)80216-0 . free .
33. Melhuish TA, Wotton D . The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF . The Journal of Biological Chemistry . 275 . 50 . 39762–6 . December 2000 . 10995736 . 10.1074/jbc.C000416200 . free .
34. Melhuish TA, Gallo CM, Wotton D . TGIF2 interacts with histone deacetylase 1 and represses transcription . The Journal of Biological Chemistry . 276 . 34 . 32109–14 . August 2001 . 11427533 . 10.1074/jbc.M103377200 . free .
35. Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W . Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1 . Genes & Development . 17 . 7 . 896–911 . April 2003 . 12670868 . 196026 . 10.1101/gad.252103 .
36. Vietor I, Vadivelu SK, Wick N, Hoffman R, Cotten M, Seiser C, Fialka I, Wunderlich W, Haase A, Korinkova G, Brosch G, Huber LA . TIS7 interacts with the mammalian SIN3 histone deacetylase complex in epithelial cells . The EMBO Journal . 21 . 17 . 4621–31 . September 2002 . 12198164 . 125408 . 10.1093/emboj/cdf461 .
37. Koipally J, Renold A, Kim J, Georgopoulos K . Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes . The EMBO Journal . 18 . 11 . 3090–100 . June 1999 . 10357820 . 1171390 . 10.1093/emboj/18.11.3090 .
38. Koipally J, Georgopoulos K . A molecular dissection of the repression circuitry of Ikaros . The Journal of Biological Chemistry . 277 . 31 . 27697–705 . August 2002 . 12015313 . 10.1074/jbc.M201694200 . free .
39. Vieyra D, Loewith R, Scott M, Bonnefin P, Boisvert FM, Cheema P, Pastyryeva S, Meijer M, Johnston RN, Bazett-Jones DP, McMahon S, Cole MD, Young D, Riabowol K . Human ING1 proteins differentially regulate histone acetylation . The Journal of Biological Chemistry . 277 . 33 . 29832–9 . August 2002 . 12015309 . 10.1074/jbc.M200197200 . free .
40. Sakai H, Urano T, Ookata K, Kim MH, Hirai Y, Saito M, Nojima Y, Ishikawa F . MBD3 and HDAC1, two components of the NuRD complex, are localized at Aurora-A-positive centrosomes in M phase . The Journal of Biological Chemistry . 277 . 50 . 48714–23 . December 2002 . 12354758 . 10.1074/jbc.M208461200 . free .
41. Saito M, Ishikawa F . The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2 . The Journal of Biological Chemistry . 277 . 38 . 35434–9 . September 2002 . 12124384 . 10.1074/jbc.M203455200 . free .
42. Ding Z, Gillespie LL, Paterno GD . Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain . Molecular and Cellular Biology . 23 . 1 . 250–8 . January 2003 . 12482978 . 140656 . 10.1128/mcb.23.1.250-258.2003 .
43. Xia ZB, Anderson M, Diaz MO, Zeleznik-Le NJ . MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein . Proceedings of the National Academy of Sciences of the United States of America . 100 . 14 . 8342–7 . July 2003 . 12829790 . 166231 . 10.1073/pnas.1436338100 . 2003PNAS..100.8342X . free .
44. Yao YL, Yang WM . The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity . The Journal of Biological Chemistry . 278 . 43 . 42560–8 . October 2003 . 12920132 . 10.1074/jbc.M302955200 . free .
45. Mazumdar A, Wang RA, Mishra SK, Adam L, Bagheri-Yarmand R, Mandal M, Vadlamudi RK, Kumar R . Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor . Nature Cell Biology . 3 . 1 . 30–7 . January 2001 . 11146623 . 10.1038/35050532 . 23477845 .
46. Ito A, Kawaguchi Y, Lai CH, Kovacs JJ, Higashimoto Y, Appella E, Yao TP . MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation . The EMBO Journal . 21 . 22 . 6236–45 . November 2002 . 12426395 . 137207 . 10.1093/emboj/cdf616 .
47. Brackertz M, Boeke J, Zhang R, Renkawitz R . Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3 . The Journal of Biological Chemistry . 277 . 43 . 40958–66 . October 2002 . 12183469 . 10.1074/jbc.M207467200 . free .
48. Wotton D, Lo RS, Lee S, Massagué J . A Smad transcriptional corepressor . Cell . 97 . 1 . 29–39 . April 1999 . 10199400 . 10.1016/s0092-8674(00)80712-6 . 6907878 . free .
49. Polesskaya A, Rudnicki MA . A MyoD-dependent differentiation checkpoint: ensuring genome integrity . Developmental Cell . 3 . 6 . 757–8 . December 2002 . 12479798 . 10.1016/s1534-5807(02)00372-6 . free .
50. Mal A, Sturniolo M, Schiltz RL, Ghosh MK, Harter ML . A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: inhibition of the myogenic program . The EMBO Journal . 20 . 7 . 1739–53 . April 2001 . 11285237 . 145490 . 10.1093/emboj/20.7.1739 .
51. Fischer DD, Cai R, Bhatia U, Asselbergs FA, Song C, Terry R, Trogani N, Widmer R, Atadja P, Cohen D . Isolation and characterization of a novel class II histone deacetylase, HDAC10 . The Journal of Biological Chemistry . 277 . 8 . 6656–66 . February 2002 . 11739383 . 10.1074/jbc.M108055200 . free .
52. Underhill C, Qutob MS, Yee SP, Torchia J . A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1 . The Journal of Biological Chemistry . 275 . 51 . 40463–70 . December 2000 . 11013263 . 10.1074/jbc.M007864200 . free .
53. Zupkovitz . Gordin . Lagger . Sabine . Martin . David . Steiner . Marianne . Hagelkruys . Astrid . Seiser . Christian . Schöfer . Christian . Pusch . Oliver . Histone deacetylase 1 expression is inversely correlated with age in the short-lived fish Nothobranchius furzeri . Histochemistry and Cell Biology . 28 June 2018 . 150 . 3 . 255–269 . 10.1007/s00418-018-1687-4. 6096771 . 29951776.
54. Milutinovic S, Zhuang Q, Szyf M . Proliferating cell nuclear antigen associates with histone deacetylase activity, integrating DNA replication and chromatin modification . The Journal of Biological Chemistry . 277 . 23 . 20974–8 . June 2002 . 11929879 . 10.1074/jbc.M202504200 . free .
55. Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T . Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression . Biochemical and Biophysical Research Communications . 322 . 2 . 601–8 . September 2004 . 15325272 . 10.1016/j.bbrc.2004.07.163 .
56. Joshi B, Ko D, Ordonez-Ercan D, Chellappan SP . A putative coiled-coil domain of prohibitin is sufficient to repress E2F1-mediated transcription and induce apoptosis . Biochemical and Biophysical Research Communications . 312 . 2 . 459–66 . December 2003 . 14637159 . 10.1016/j.bbrc.2003.10.148 .
57. Wang S, Fusaro G, Padmanabhan J, Chellappan SP . Prohibitin co-localizes with Rb in the nucleus and recruits N-CoR and HDAC1 for transcriptional repression . Oncogene . 21 . 55 . 8388–96 . December 2002 . 12466959 . 10.1038/sj.onc.1205944 . 22880111 .
58. Khan MM, Nomura T, Kim H, Kaul SC, Wadhwa R, Shinagawa T, Ichikawa-Iwata E, Zhong S, Pandolfi PP, Ishii S . Role of PML and PML-RARalpha in Mad-mediated transcriptional repression . Molecular Cell . 7 . 6 . 1233–43 . June 2001 . 11430826 . 10.1016/s1097-2765(01)00257-x . free .
59. Wu WS, Vallian S, Seto E, Yang WM, Edmondson D, Roth S, Chang KS . The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases . Molecular and Cellular Biology . 21 . 7 . 2259–68 . April 2001 . 11259576 . 86860 . 10.1128/MCB.21.7.2259-2268.2001 .
60. Cai RL, Yan-Neale Y, Cueto MA, Xu H, Cohen D . HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins . The Journal of Biological Chemistry . 275 . 36 . 27909–16 . September 2000 . 10846170 . 10.1074/jbc.M000168200 . free .
61. Nicolas E, Ait-Si-Ali S, Trouche D . The histone deacetylase HDAC3 targets RbAp48 to the retinoblastoma protein . Nucleic Acids Research . 29 . 15 . 3131–6 . August 2001 . 11470869 . 55834 . 10.1093/nar/29.15.3131 .
62. Hassig CA, Fleischer TC, Billin AN, Schreiber SL, Ayer DE . Histone deacetylase activity is required for full transcriptional repression by mSin3A . Cell . 89 . 3 . 341–7 . May 1997 . 9150133 . 10.1016/s0092-8674(00)80214-7 . 14233219 . free .
63. Ng HH, Zhang Y, Hendrich B, Johnson CA, Turner BM, Erdjument-Bromage H, Tempst P, Reinberg D, Bird A . MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex . Nature Genetics . 23 . 1 . 58–61 . September 1999 . 10471499 . 10.1038/12659 . 1842/684 . 6147725 . free .
64. Zhong H, May MJ, Jimi E, Ghosh S . The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1 . Molecular Cell . 9 . 3 . 625–36 . March 2002 . 11931769 . 10.1016/s1097-2765(02)00477-x . free .
65. Kiernan R, Brès V, Ng RW, Coudart MP, El Messaoudi S, Sardet C, Jin DY, Emiliani S, Benkirane M . Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65 . The Journal of Biological Chemistry . 278 . 4 . 2758–66 . January 2003 . 12419806 . 10.1074/jbc.M209572200 . free .
66. Anderson LA, Perkins ND . The large subunit of replication factor C interacts with the histone deacetylase, HDAC1 . The Journal of Biological Chemistry . 277 . 33 . 29550–4 . August 2002 . 12045192 . 10.1074/jbc.M200513200 . free .
67. Dick FA, Sailhamer E, Dyson NJ . Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins . Molecular and Cellular Biology . 20 . 10 . 3715–27 . May 2000 . 10779361 . 85672 . 10.1128/mcb.20.10.3715-3727.2000 .
68. Fuks F, Burgers WA, Brehm A, Hughes-Davies L, Kouzarides T . DNA methyltransferase Dnmt1 associates with histone deacetylase activity . Nature Genetics . 24 . 1 . 88–91 . January 2000 . 10615135 . 10.1038/71750 . 20428600 .
69. Luo RX, Postigo AA, Dean DC . Rb interacts with histone deacetylase to repress transcription . Cell . 92 . 4 . 463–73 . February 1998 . 9491888 . 10.1016/s0092-8674(00)80940-x . 18857544 . free .
70. Lai A, Lee JM, Yang WM, DeCaprio JA, Kaelin WG, Seto E, Branton PE . RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins . Molecular and Cellular Biology . 19 . 10 . 6632–41 . October 1999 . 10490602 . 84642 . 10.1128/mcb.19.10.6632 .
71. Ferreira R, Magnaghi-Jaulin L, Robin P, Harel-Bellan A, Trouche D . The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase . Proceedings of the National Academy of Sciences of the United States of America . 95 . 18 . 10493–8 . September 1998 . 9724731 . 27922 . 10.1073/pnas.95.18.10493 . 1998PNAS...9510493F . free .
72. Bouzahzah B, Fu M, Iavarone A, Factor VM, Thorgeirsson SS, Pestell RG . Transforming growth factor-beta1 recruits histone deacetylase 1 to a p130 repressor complex in transgenic mice in vivo . Cancer Research . 60 . 16 . 4531–7 . August 2000 . 10969803 .
73. Huang NE, Lin CH, Lin YS, Yu WC . Modulation of YY1 activity by SAP30 . Biochemical and Biophysical Research Communications . 306 . 1 . 267–75 . June 2003 . 12788099 . 10.1016/S0006-291X(03)00966-5 .
74. Zhang Y, Sun ZW, Iratni R, Erdjument-Bromage H, Tempst P, Hampsey M, Reinberg D . SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex . Molecular Cell . 1 . 7 . 1021–31 . June 1998 . 9651585 . 10.1016/s1097-2765(00)80102-1 . free .
75. Swanson KA, Knoepfler PS, Huang K, Kang RS, Cowley SM, Laherty CD, Eisenman RN, Radhakrishnan I . HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations . Nature Structural & Molecular Biology . 11 . 8 . 738–46 . August 2004 . 15235594 . 10.1038/nsmb798 . 44324333 .
76. Yochum GS, Ayer DE . Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex . Molecular and Cellular Biology . 21 . 13 . 4110–8 . July 2001 . 11390640 . 87072 . 10.1128/MCB.21.13.4110-4118.2001 .
77. Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D . Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1) . Molecular and Cellular Biology . 22 . 3 . 835–48 . February 2002 . 11784859 . 133546 . 10.1128/mcb.22.3.835-848.2002 .
78. Grozinger CM, Hassig CA, Schreiber SL . Three proteins define a class of human histone deacetylases related to yeast Hda1p . Proceedings of the National Academy of Sciences of the United States of America . 96 . 9 . 4868–73 . April 1999 . 10220385 . 21783 . 10.1073/pnas.96.9.4868 . 1999PNAS...96.4868G . free .
79. You A, Tong JK, Grozinger CM, Schreiber SL . CoREST is an integral component of the CoREST- human histone deacetylase complex . Proceedings of the National Academy of Sciences of the United States of America . 98 . 4 . 1454–8 . February 2001 . 11171972 . 29278 . 10.1073/pnas.98.4.1454 . 2001PNAS...98.1454Y . free .
80. Yasui D, Miyano M, Cai S, Varga-Weisz P, Kohwi-Shigematsu T . SATB1 targets chromatin remodelling to regulate genes over long distances . Nature . 419 . 6907 . 641–5 . October 2002 . 12374985 . 10.1038/nature01084 . 2002Natur.419..641Y . 25822700 .
81. Zhang Y, Dufau ML . Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes . The Journal of Steroid Biochemistry and Molecular Biology . 85 . 2–5 . 401–14 . June 2003 . 12943729 . 10.1016/s0960-0760(03)00230-9 . 28512341 .
82. Zhang Y, Dufau ML . Silencing of transcription of the human luteinizing hormone receptor gene by histone deacetylase-mSin3A complex . The Journal of Biological Chemistry . 277 . 36 . 33431–8 . September 2002 . 12091390 . 10.1074/jbc.M204417200 . free .
83. Fleischer TC, Yun UJ, Ayer DE . Identification and characterization of three new components of the mSin3A corepressor complex . Molecular and Cellular Biology . 23 . 10 . 3456–67 . May 2003 . 12724404 . 164750 . 10.1128/mcb.23.10.3456-3467.2003 .
84. Yang L, Mei Q, Zielinska-Kwiatkowska A, Matsui Y, Blackburn ML, Benedetti D, Krumm AA, Taborsky GJ, Chansky HA . An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B . The Biochemical Journal . 369 . Pt 3 . 651–7 . February 2003 . 12398767 . 1223118 . 10.1042/BJ20020854 .
85. Zhang J, Kalkum M, Chait BT, Roeder RG . The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2 . Molecular Cell . 9 . 3 . 611–23 . March 2002 . 11931768 . 10.1016/s1097-2765(02)00468-9 . free .
86. Huang EY, Zhang J, Miska EA, Guenther MG, Kouzarides T, Lazar MA . Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway . Genes & Development . 14 . 1 . 45–54 . January 2000 . 10.1101/gad.14.1.45 . 10640275 . 316335 .
87. Shi Y, Downes M, Xie W, Kao HY, Ordentlich P, Tsai CC, Hon M, Evans RM . Sharp, an inducible cofactor that integrates nuclear receptor repression and activation . Genes & Development . 15 . 9 . 1140–51 . May 2001 . 11331609 . 312688 . 10.1101/gad.871201 .
88. Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA . Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex . Molecular and Cellular Biology . 22 . 8 . 2743–50 . April 2002 . 11909966 . 133736 . 10.1128/mcb.22.8.2743-2750.2002 .
89. Vaute O, Nicolas E, Vandel L, Trouche D . Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases . Nucleic Acids Research . 30 . 2 . 475–81 . January 2002 . 11788710 . 99834 . 10.1093/nar/30.2.475 .
90. Di Padova M, Bruno T, De Nicola F, Iezzi S, D'Angelo C, Gallo R, Nicosia D, Corbi N, Biroccio A, Floridi A, Passananti C, Fanciulli M . Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter . The Journal of Biological Chemistry . 278 . 38 . 36496–504 . September 2003 . 12847090 . 10.1074/jbc.M306694200 . free .
91. Singh J, Murata K, Itahana Y, Desprez PY . Constitutive expression of the Id-1 promoter in human metastatic breast cancer cells is linked with the loss of NF-1/Rb/HDAC-1 transcription repressor complex . Oncogene . 21 . 12 . 1812–22 . March 2002 . 11896613 . 10.1038/sj.onc.1205252 . 30129174 .
92. Sun JM, Chen HY, Moniwa M, Litchfield DW, Seto E, Davie JR . The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2 . The Journal of Biological Chemistry . 277 . 39 . 35783–6 . September 2002 . 12176973 . 10.1074/jbc.C200378200 . free .
93. Tsai SC, Valkov N, Yang WM, Gump J, Sullivan D, Seto E . Histone deacetylase interacts directly with DNA topoisomerase II . Nature Genetics . 26 . 3 . 349–53 . November 2000 . 11062478 . 10.1038/81671 . 19301396 .
94. Johnson CA, Padget K, Austin CA, Turner BM . Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis . The Journal of Biological Chemistry . 276 . 7 . 4539–42 . February 2001 . 11136718 . 10.1074/jbc.C000824200 . free .
95. David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A . Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein . Oncogene . 16 . 19 . 2549–56 . May 1998 . 9627120 . 10.1038/sj.onc.1202043 . 655636 .
96. Chauchereau A, Mathieu M, de Saintignon J, Ferreira R, Pritchard LL, Mishal Z, Dejean A, Harel-Bellan A . HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF . Oncogene . 23 . 54 . 8777–84 . November 2004 . 15467736 . 10.1038/sj.onc.1208128 . 26092755 .
97. Wong CW, Privalsky ML . Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6 . The Journal of Biological Chemistry . 273 . 42 . 27695–702 . October 1998 . 9765306 . 10.1074/jbc.273.42.27695 . free .