Histone-arginine N-methyltransferase explained

Histone-arginine N-methyltransferase
Ec Number:	2.1.1.125
Cas Number:	445295-80-7

Histone-arginine N-methyltransferase (histone protein methylase I, nuclear protein (histone) N-methyltransferase, protein methylase I, S-adenosyl-L-methionine:histone-arginine omega-N-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:histone-arginine Nomega-methyltransferase.^{[1] [2]} This enzyme catalyses the following chemical reaction

\rightleftharpoons S-adenosyl-L-homocysteine + histone-Nomega-methyl-arginine

The enzyme forms the Nomega-monomethyl- and Nomega,Nomega'-dimethyl.

Notes and References

1. Rajpurohit R, Lee SO, Park JO, Paik WK, Kim S . Enzymatic methylation of recombinant heterogeneous nuclear RNP protein A1. Dual substrate specificity for S-adenosylmethionine:histone-arginine N-methyltransferase . The Journal of Biological Chemistry . 269 . 2 . 1075–82 . January 1994 . 8288564 .
2. Rawal N, Rajpurohit R, Paik WK, Kim S . Purification and characterization of S-adenosylmethionine-protein-arginine N-methyltransferase from rat liver . The Biochemical Journal . 300 (Pt 2) . Pt 2 . 483–9 . June 1994 . 8002954 . 1138188 . 10.1042/bj3000483 .