Histidinol-phosphatase explained

histidinol-phosphatase
Ec Number:3.1.3.15
Cas Number:9025-79-0
Go Code:0004401
Width:270

The enzyme histidinol-phosphatase (EC 3.1.3.15) catalyzes the reaction

L-histidinol phosphate + H2O

\rightleftharpoons

L-histidinol + phosphate

This enzyme participates in histidine metabolism.

Nomenclature

This enzyme belongs to the family of hydrolases, to be specific, those acting on phosphoric monoester bonds. The systematic name is L-histidinol-phosphate phosphohydrolase. Other names in common use include histidinol phosphate phosphatase, L-histidinol phosphate phosphatase, histidinolphosphate phosphatase, HPpase, and histidinolphosphatase.

E. coli

See main article: hisB. In E. coli the enzyme encoded by the gene hisB is a fused imidazoleglycerol-phosphate dehydratase and histidinol-phosphatase.[1]

Further reading

Notes and References

  1. Brilli M, Fani R . Molecular evolution of hisB genes . Journal of Molecular Evolution . 58 . 2 . 225–237 . February 2004 . 15042344 . 10.1007/s00239-003-2547-x . 2004JMolE..58..225B . 1684458 .