Histamine agonist explained

A histamine agonist is a drug which causes increased activity at one or more of the four histamine receptor subtypes.

H1 agonists promote wakefulness.[1]

H2: Betazole and Impromidine are examples of agonists used in diagnostics to increase histamine.

H3: Betahistine is a weak Histamine1 agonist and a very strong antagonist of the Histamine3 autoreceptor. Antagonizing H3 increases histaminergic tone.

See also

Notes and References

  1. Book: Sakai, N. . Nishino . S. . Encyclopedia of Sleep . Wake-Promoting Medications . Elsevier . 2013 . 978-0-12-378611-1 . 10.1016/b978-0-12-378610-4.00126-1 . 627–633. Although centrally injected histamine or histaminergic H1 agonists promote wakefulness, the systemic administration of these compounds induces various unacceptable side effects via peripheral H1 receptor stimulation..

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