Hippuristanol Explained

Hippuristanol is a small molecule found in the coral Isis hippuris[1] which was discovered by Jerry Pelletier and others of McGill University in Montreal, Quebec, Canada.[2] It appears to have anti-viral activity and may hold promise as a cancer therapy.[3] Binds to and inhibits the eukaryotic translation initiation factor protein eIF4A.[4]

See also

Notes and References

  1. 10.1038/nchembio776 . 2 . Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A . 2006 . Nature Chemical Biology . 213–220 . Bordeleau . Marie-Eve . Mori . Ayaka . Oberer . Monika . Lindqvist . Lisa . Chard . Louisa S . Higa . Tatsuo . Belsham . Graham J . Wagner . Gerhard . Tanaka . Junichi . Pelletier . Jerry. 4 . 16532013 . 15635690 .
  2. http://www.sciencebase.com/science-blog/coral-kills-virus.html Killer Coral Compound
  3. http://www.sciam.com/article.cfm?articleID=000A9304-02D9-1412-82D983414B7F0000 Compound from Coral Could Combat Cancer
  4. Cencic . Regina . Pelletier . Jerry . Hippuristanol - A potent steroid inhibitor of eukaryotic initiation factor 4A . Translation . Informa UK Limited . 4 . 1 . 2016-01-02 . 2169-0731 . 10.1080/21690731.2015.1137381 . e1137381. 4909409 . 27335721.

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