Hexobendine Explained

Hexobendine is a vasodilator that acts as an adenosine reuptake inhibitor.^[1]

Synthesis

Hexobendine can be synthesized starting with a reaction between 3,4,5-trimethoxybenzoyl chloride (1) and 3-chloropropanol (2) to give the corresponding ester, 3-chloropropyl 3,4,5-trimethoxybenzoate (3). The last step involves the reaction between two molar equivalents of 3 with one molar equivalent of 1,2-dimethylethylenediamine (4) completing the synthesis of hexobendine (5).^{[2] [3]}

See also

• Dilazep

Notes and References

1. Kolassa N, Pfleger K . Adenosine uptake by erythrocytes of man, rat and guinea-pig and its inhibition by hexobendine and dipyridamole . Biochemical Pharmacology . 24 . 1 . 154–6 . January 1975 . 1168469 . 10.1016/0006-2952(75)90331-7 .
2. Web site: Pharmaceutical Substances: Hexobendine . Thieme .
3. AT231432 idem Schlogl Karl, Kraupp Otto, (1964 & 1966 to Chemie Linz Ag).