Hepatocyte nuclear factor 4 gamma explained

Hepatocyte nuclear factor 4 gamma (HNF4G) also known as NR2A2 (nuclear receptor subfamily 2, group A, member 2) is a nuclear receptor that in humans is encoded by the HNF4G gene.^{[1] [2] [3]}

Function

HNF4G is a transcription factor that has been shown to play a significant role in intestinal epithelial cell differentiation and function. Research using integrative multi-omics analysis of intestinal organoid differentiation has revealed that HNF4G acts as a master regulator of gene regulation in differentiation towards the enterocyte lineage.^[4] The study demonstrated widespread binding to promoters and enhancers that are activated in enterocytes, and that the loss of Hnf4g results in a partial loss of enterocyte differentiation, indicating its importance in maintaining the enterocyte lineage.

See also

• Hepatocyte nuclear factor 4
• Hepatocyte nuclear factors

Further reading

• Plengvidhya N, Antonellis A, Wogan LT, Poleev A, Borgschulze M, Warram JH, Ryffel GU, Krolewski AS, Doria A . Hepatocyte nuclear factor-4gamma: cDNA sequence, gene organization, and mutation screening in early-onset autosomal-dominant type 2 diabetes . Diabetes . 48 . 10 . 2099–2102 . October 1999 . 10512380 . 10.2337/diabetes.48.10.2099 .
• Ozeki T, Takahashi Y, Nakayama K, Funayama M, Nagashima K, Kodama T, Kamataki T . Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference in the expression of human dihydrodiol dehydrogenase 4 mRNA in human livers . Pharmacogenetics . 13 . 1 . 49–53 . January 2003 . 12544512 . 10.1097/00008571-200301000-00007 .

Notes and References

1. Web site: Entrez Gene: HNF4G hepatocyte nuclear factor 4, gamma.
2. Drewes T, Senkel S, Holewa B, Ryffel GU . Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes . Molecular and Cellular Biology . 16 . 3 . 925–931 . March 1996 . 8622695 . 231074 . 10.1128/mcb.16.3.925 .
3. Wisely GB, Miller AB, Davis RG, Thornquest AD, Johnson R, Spitzer T, Sefler A, Shearer B, Moore JT, Miller AB, Willson TM, Williams SP . Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids . Structure . 10 . 9 . 1225–1234 . September 2002 . 12220494 . 10.1016/S0969-2126(02)00829-8 . free .
4. Lindeboom RG, van Voorthuijsen L, Oost KC, Rodríguez-Colman MJ, Luna-Velez MV, Furlan C, Baraille F, Jansen PW, Ribeiro A, Burgering BM, Snippert HJ, Vermeulen M . Integrative multi-omics analysis of intestinal organoid differentiation . Molecular Systems Biology . 14 . 6 . e8227 . June 2018 . 29945941 . 6018986 . 10.15252/msb.20188227 .