Helper-component proteinase explained

Helper-component proteinase
Ec Number:3.4.22.45
Cas Number:124566-20-7

Helper-component proteinase (HC-Pro) is an enzyme.[1] [2] This enzyme catalyses the following chemical reaction

Hydrolyses a Gly-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-Gly, in the processing of the potyviral polyprotein

This enzyme is present in plant RNA viruses of the Potyviridae family. HC-Pro is encoded by all potyviruses, but is absent in some members of the Ipomovirus genus.[3] HC-Pro is involved in virus transmission, virus polyprotein processing, and suppression of RNA silencing, an antiviral mechanism of plants.[4]

Notes and References

  1. Kasschau KD, Carrington JC . Requirement for HC-Pro processing during genome amplification of tobacco etch potyvirus . Virology . 209 . 1 . 268–73 . May 1995 . 7747479 . 10.1006/viro.1995.1254 . free .
  2. Book: Potyvirus helper component proteinase . Handbook of Proteolytic Enzymes . Verchot, J. . 1998 . 677–679 . Barrett, A.J. . Rawlings, N.D. . Woessner, J.F. . Handbook of Proteolytic Enzymes . London .
  3. Pasin . Fabio . Daròs . José-Antonio . Tzanetakis . Ioannis E . Proteome expansion in the Potyviridae evolutionary radiation . FEMS Microbiology Reviews . 2022 . 46 . 4 . en . fuac011 . 10.1093/femsre/fuac011 . 35195244 . 9249622 . 1574-6976.
  4. Valli . Adrián A. . Gallo . Araiz . Rodamilans . Bernardo . López-Moya . Juan José . García . Juan Antonio . March 2018 . The HCPro from the Potyviridae family: an enviable multitasking Helper Component that every virus would like to have: The HCPro from the Potyviridae family . Molecular Plant Pathology . en . 19 . 3 . 744–763 . 10.1111/mpp.12553 . 6638112 . 28371183.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Helper-component proteinase".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.