Harmol Explained

Harmol is a chemical compound classified as a β-carboline.[1] [2] [3] It is readily formed in vivo in humans by O-demethylation of harmine.[4]

See also

Notes and References

  1. Abe A, Kokuba H . Harmol induces autophagy and subsequent apoptosis in U251MG human glioma cells through the downregulation of survivin . Oncol Rep . 2013 . 29 . 4 . 1333–42 . 23338618 . 10.3892/or.2013.2242 . free .
  2. El Gendy MA, Soshilov AA, Denison MS, El-Kadi AO . Transcriptional and posttranslational inhibition of dioxin-mediated induction of CYP1A1 by harmine and harmol . Toxicol Lett . 2012 . 208 . 1 . 51–61 . 22001777 . 10.1016/j.toxlet.2011.09.030 . 3263333 .
  3. Abe A, Yamada H, Moriya S, Miyazawa K . The β-carboline alkaloid harmol induces cell death via autophagy but not apoptosis in human non-small cell lung cancer A549 cells. . Biol Pharm Bull . 2011 . 34 . 8 . 1264–72 . 21804216 . 10.1248/bpb.34.1264. free .
  4. Morales-Garcia JA, de la Fuenta Revenga M, Alonso-Gil S, Rodriguez-Franco MI, Feiding A, Perez-Castillo A, Riba J . The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro . Sci. Rep. . 7 . 1 . 5309 . 2017 . 28706205 . 5509699 . 10.1038/s41598-017-05407-9 . 2017NatSR...7.5309M .

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