Haplogroup Explained

A haplotype is a group of alleles in an organism that are inherited together from a single parent, and a haplogroup (haploid from the Greek, Modern (1453-);: ἁπλοῦς, haploûs, "onefold, simple" and English: group) is a group of similar haplotypes that share a common ancestor with a single-nucleotide polymorphism mutation. More specifically, a haplotype is a combination of alleles at different chromosomal regions that are closely linked and that tend to be inherited together. As a haplogroup consists of similar haplotypes, it is usually possible to predict a haplogroup from haplotypes. Haplogroups pertain to a single line of descent. As such, membership of a haplogroup, by any individual, relies on a relatively small proportion of the genetic material possessed by that individual.

Each haplogroup originates from, and remains part of, a preceding single haplogroup (or paragroup). As such, any related group of haplogroups may be precisely modelled as a nested hierarchy, in which each set (haplogroup) is also a subset of a single broader set (as opposed, that is, to biparental models, such as human family trees). Haplogroups can be further divided into subclades.

Haplogroups are normally identified by an initial letter of the alphabet, and refinements consist of additional number and letter combinations, such as (for example) . The alphabetical nomenclature was published in 2002 by the Y Chromosome Consortium.^[1]

In human genetics, the haplogroups most commonly studied are Y-chromosome (Y-DNA) haplogroups and mitochondrial DNA (mtDNA) haplogroups, each of which can be used to define genetic populations. Y-DNA is passed solely along the patrilineal line, from father to son, while mtDNA is passed down the matrilineal line, from mother to offspring of both sexes. Neither recombines, and thus Y-DNA and mtDNA change only by chance mutation at each generation with no intermixture between parents' genetic material.

Haplogroup formation

Mitochondria are small organelles that lie in the cytoplasm of eukaryotic cells, such as those of humans. Their primary function is to provide energy to the cell. Mitochondria are thought to be reduced descendants of symbiotic bacteria that were once free living. One indication that mitochondria were once free living is that each contains a circular DNA, called mitochondrial DNA (mtDNA), whose structure is more similar to bacteria than eukaryotic organisms (see endosymbiotic theory). The overwhelming majority of a human's DNA is contained in the chromosomes in the nucleus of the cell, but mtDNA is an exception.An individual inherits their cytoplasm and the organelles contained by that cytoplasm exclusively from the maternal ovum (egg cell); sperm only pass on the chromosomal DNA, all paternal mitochondria are digested in the oocyte. When a mutation arises in a mtDNA molecule, the mutation is therefore passed down in a direct female line of descent. Mutations are changes in the nitrogen bases of the DNA sequence. Single changes from the original sequence are called single nucleotide polymorphisms (SNPs).

Human Y chromosomes are male-specific sex chromosomes; nearly all humans that possess a Y chromosome will be morphologically male. Although Y chromosomes are situated in the cell nucleus and paired with X chromosomes, they only recombine with the X chromosome at the ends of the Y chromosome; the remaining 95% of the Y chromosome does not recombine. Therefore, the Y chromosome and any mutations that arise in it are passed down in a direct male line of descent.

Other chromosomes, autosomes and X chromosomes (when another X chromosome is available to pair with it), share their genetic material during meiosis, the process of cell division which produces gametes. Effectively this means that the genetic material from these chromosomes gets mixed up in every generation, and so any new mutations are passed down randomly from parents to offspring.

The special feature that both Y chromosomes and mtDNA display is that mutations can accrue along a certain segment of both molecules and these mutations remain fixed in place on the DNA. Furthermore, the historical sequence of these mutations can also be inferred. For example, if a set of ten Y chromosomes (derived from ten different individuals) contains a mutation, A, but only five of these chromosomes contain a second mutation, B, then it must be the case that mutation B occurred after mutation A.

Furthermore, all ten individuals who carry the chromosome with mutation A are the direct male line descendants of the same man who was the first person to carry this mutation. The first man to carry mutation B was also a direct male line descendant of this man, but is also the direct male line ancestor of all men carrying mutation B. Series of mutations such as this form molecular lineages. Furthermore, each mutation defines a set of specific Y chromosomes called a haplogroup.

All humans carrying mutation A form a single haplogroup, and all humans carrying mutation B are part of this haplogroup, but mutation B also defines a more recent haplogroup (which is a subgroup or subclade) of its own to which humans carrying only mutation A do not belong. Both mtDNA and Y chromosomes are grouped into lineages and haplogroups; these are often presented as tree-like diagrams.

Human Y-chromosome DNA haplogroups

See main article: Human Y-chromosome DNA haplogroup. Human Y chromosome DNA (Y-DNA) haplogroups are named from A to T, and are further subdivided using numbers and lower case letters. Y chromosome haplogroup designations are established by the Y Chromosome Consortium.^[2]

Y-chromosomal Adam is the name given by researchers to the male who is the most recent common patrilineal (male-lineage) ancestor of all living humans.

Major Y-chromosome haplogroups, and their geographical regions of occurrence (prior tothe recent European colonization), include:

Groups without mutation M168

• Haplogroup A (M91) (Africa, especially the Khoisan and Nilotes)
• Haplogroup B (M60) (Africa, especially the Pygmies and Hadzabe)

Groups with mutation M168

(mutation M168 occurred ~50,000 bp)

• Haplogroup C (M130) (Oceania, North/Central/East Asia, North America and a minor presence in South America, Southeast Asia, South Asia, West Asia, and Europe)
• YAP+ haplogroups
  • Haplogroup DE (M1, M145, M203)
    • Haplogroup D (CTS3946) (Tibet, Nepal, Japan, the Andaman Islands, Central Asia, and a sporadic presence in Nigeria, Syria, and Saudi Arabia)
    • Haplogroup E (M96)
      • Haplogroup E1b1a (V38) West Africa and surrounding regions; formerly known as E3a
      • Haplogroup E1b1b (M215) Associated with the spread of Afroasiatic languages; now concentrated in North Africa and the Horn of Africa, as well as parts of the Middle East, the Mediterranean, and the Balkans; formerly known as E3b

Groups with mutation M89

(mutation M89 occurred ~45,000 bp)

• Haplogroup F (M89) Oceania, Europe, Asia, North and South America
  • Haplogroup FT (P14, M213) (China, Vietnam,^[3] Singapore^[4])
• Haplogroup G (M201) (present among many ethnic groups in Eurasia, usually at low frequency; most common in the Caucasus, the Iranian plateau, and Anatolia; in Europe mainly in Greece, Italy, Iberia, the Tyrol, Bohemia; rare in Northern Europe)
• Haplogroup H (L901/M2939)
  • H1'3 (Z4221/M2826, Z13960)
    • H1 (L902/M3061)
      • H1a (M69/Page45) India, Sri Lanka, Nepal, Pakistan, Iran, Central Asia
      • H1b (B108) Found in a Burmese individual in Myanmar.
    • H3 (Z5857) India, Sri Lanka, Pakistan, Bahrain, Qatar
  • H2 (P96) Formerly known as haplogroup F3. Found with low frequency in Europe and western Asia.
• Haplogroup IJK (L15, L16)

Groups with mutations L15 & L16

• Haplogroup IJK (L15, L16)
  • Haplogroup IJ (S2, S22)
    • Haplogroup I (M170, P19, M258) (widespread in Europe, found infrequently in parts of the Middle East, and virtually absent elsewhere^[5])
      • Haplogroup I1 (M253, M307, P30, P40) (Northern Europe, dominant in Scandinavia)
      • Haplogroup I2 (S31) (Central and Southeast Europe, Sardinia, Balkans)
    • Haplogroup J (M304) (the Middle East, Turkey, Caucasus, Italy, Greece, the Balkans, North Africa)
      • Haplogroup J* (Mainly found in Socotra, with a few observations in Pakistan, Oman, Greece, the Czech Republic, and among Turkic peoples)
      • Haplogroup J1 (M267) (Mostly associated with Semitic peoples in the Middle East but also found in; Mediterranean Europe, Ethiopia, North Africa, Pakistan, India and with Northeast Caucasian peoples in Dagestan; J1 with DYS388=13 is associated with eastern Anatolia)
      • Haplogroup J2 (M172) (Mainly found in West Asia, Central Asia, Iran, Italy, Greece, the Balkans and North Africa)
  • Haplogroup K (M9, P128, P131, P132)

Groups with mutation M9

(mutation M9 occurred ~40,000 bp)

• Haplogroup K
  • Haplogroup LT (L298/P326)
    • Haplogroup L (M11, M20, M22, M61, M185, M295) (South Asia, Central Asia, Southwestern Asia, the Mediterranean)
    • Haplogroup T (M70, M184/USP9Y+3178, M193, M272) (North Africa, Horn of Africa, Southwest Asia, the Mediterranean, South Asia); formerly known as Haplogroup K2
  • Haplogroup K(xLT) (rs2033003/M526)

Groups with mutation M526

• • Haplogroup M (P256) (New Guinea, Melanesia, eastern Indonesia)
  • Haplogroup NO (M214)
    • Haplogroup N (M231) (northernmost Eurasia)
    • Haplogroup O (M175) (East Asia, Southeast Asia, the South Pacific, South Asia, Central Asia)
      • Haplogroup O1 (F265)
        • Haplogroup O1a (M119)
        • Haplogroup O1b (P31, M268)
      • Haplogroup O2 (M122)
  • Haplogroup P-M45 (M45) (M45 occurred ~35,000 bp)
    • Haplogroup Q-M242 (M242) (Occurred ~15,000–20,000 bp. Found in Asia and the Americas)
      • Haplogroup Q-M3 (M3) (North America, Central America, and South America)
    • Haplogroup R (M207)
      • Haplogroup R1 (M173)
        • Haplogroup R1a (M17) (Central Asia, South Asia, and Central, Northern, and Eastern Europe)
        • Haplogroup R1b (M343) (Europe, Caucasus, Central Asia, South Asia, North Africa, Central Africa)
      • Haplogroup R2 (M124) (South Asia, Caucasus, Central Asia)
  • Haplogroup S (M230, P202, P204) (New Guinea, Melanesia, eastern Indonesia)

Human mitochondrial DNA haplogroups

See main article: Human mitochondrial DNA haplogroup. Human mtDNA haplogroups are lettered:A,B,C,CZ,D,E,F,G,H,HV,I,J,pre-JT,JT,K,L0,L1,L2,L3,L4,L5,L6,M,N,O,P,Q,R,R0,S,T,U,V,W,X,Y, andZ. The most up-to-date version of the mtDNA tree is maintained by Mannis van Oven on the PhyloTree website.^[6]

Mitochondrial Eve is the name given by researchers to the woman who is the most recent common matrilineal (female-lineage) ancestor of all living humans.

Defining populations

Haplogroups can be used to define genetic populations and are often geographically oriented. For example, the following are common divisions for mtDNA haplogroups:

• African: L0, L1, L2, L3, L4, L5, L6
• West Eurasian: H, T, U, V, X, K, I, J, W (all listed West Eurasian haplogroups are derived from macro-haplogroup N)^[7]
• East Eurasian: A, B, C, D, E, F, G, Y, Z (note: C, D, E, G, and Z belong to macro-haplogroup M)
• Native American: A, B, C, D, X
• Australo-Melanesian: P, Q, S

The mitochondrial haplogroups are divided into three main groups, which are designated by the sequential letters L, M, N.Humanity first split within the L group between L0 and L1-6. L1-6 gave rise to other L groups, one of which, L3, split into the M and N group.

The M group comprises the first wave of human migration which is thought to have evolved outside of Africa, following an eastward route along southern coastal areas. Descendant lineages of haplogroup M are now found throughout Asia, the Americas, and Melanesia, as well as in parts of the Horn of Africa and North Africa; almost none have been found in Europe. The N haplogroup may represent another macrolineage that evolved outside of Africa, heading northward instead of eastward. Shortly after the migration, the large R group split off from the N.

Haplogroup R consists of two subgroups defined on the basis of their geographical distributions, one found in southeastern Asia and Oceania and the other containing almost all of the modern European populations. Haplogroup N(xR), i.e. mtDNA that belongs to the N group but not to its R subgroup, is typical of Australian aboriginal populations, while also being present at low frequencies among many populations of Eurasia and the Americas.

The L type consists of nearly all Africans.

The M type consists of:

M1 – Ethiopian, Somali and Indian populations. Likely due to much gene flow between the Horn of Africa and the Arabian Peninsula (Saudi Arabia, Yemen, Oman), separated only by a narrow strait between the Red Sea and the Gulf of Aden.

CZ – Many Siberians; branch C – Some Amerindian; branch Z – Many Saami, some Korean, some North Chinese, some Central Asian populations.

D – Some Amerindians, many Siberians and northern East Asians

E – Malay, Borneo, Philippines, Taiwanese aborigines, Papua New Guinea

G – Many Northeast Siberians, northern East Asians, and Central Asians

Q – Melanesian, Polynesian, New Guinean populations

The N type consists of:

A – Found in many Amerindians and some East Asians and Siberians

I – 10% frequency in Northern, Eastern Europe

S – Some Indigenous Australian (First Nations People of Australia)

W – Some Eastern Europeans, South Asians, and southern East Asians

X – Some Amerindians, Southern Siberians, Southwest Asians, and Southern Europeans

Y – Most Nivkhs and people of Nias; many Ainus, Tungusic people, and Austronesians; also found with low frequency in some other populations of Siberia, East Asia, and Central Asia

R – Large group found within the N type. Populations contained therein can be divided geographically into West Eurasia and East Eurasia. Almost all European populations and a large number of Middle-Eastern population today are contained within this branch. A smaller percentage is contained in other N type groups (See above). Below are subclades of R:

B – Some Chinese, Tibetans, Mongolians, Central Asians, Koreans, Amerindians, South Siberians, Japanese, Austronesians

F – Mainly found in southeastern Asia, especially Vietnam; 8.3% in Hvar Island in Croatia.^[8]

R0 – Found in Arabia and among Ethiopians and Somalis; branch HV (branch H; branch V) – Europe, Western Asia, North Africa;

Pre-JT – Arose in the Levant (modern Lebanon area), found in 25% frequency in Bedouin populations; branch JT (branch J; branch T) – North, Eastern Europe, Indus, Mediterranean

U – High frequency in West Eurasia, Indian sub-continent, and Algeria, found from India to the Mediterranean and to the rest of Europe; U5 in particular shows high frequency in Scandinavia and Baltic countries with the highest frequency in the Sami people.

Y-chromosome and MtDNA geographic haplogroup assignation

Here is a list of Y-chromosome and MtDNA geographic haplogroup assignation proposed by Bekada et al. 2013.^[9]

Y-chromosome

According to SNPS haplogroups which are the age of the first extinction event tend to be around 45–50 kya. Haplogroups of the second extinction event seemed to diverge 32–35 kya according to Mal'ta. The ground zero extinction event appears to be Toba during which haplogroup CDEF* appeared to diverge into C, DE and F. C and F have almost nothing in common while D and E have plenty in common. Extinction event #1 according to current estimates occurred after Toba, although older ancient DNA could push the ground zero extinction event to long before Toba, and push the first extinction event here back to Toba. Haplogroups with extinction event notes by them have a dubious origin and this is because extinction events lead to severe bottlenecks, so all notes by these groups are just guesses. Note that the SNP counting of ancient DNA can be highly variable meaning that even though all these groups diverged around the same time no one knows when.^{[10] [11]}

Origin	Haplogroup	Marker
Europe (Second Extinction Event?)	I	M170, M253, P259, M227, M507
Europe	I1b	P215, M438, P37.2, M359, P41.2
Europe	I1b2	M26
Europe	I1c	M223, M284, P78, P95
Europe	J2a1	M47
Europe	J2a2	M67, M166
Europe	J2a2a	M92
Europe	J2b	M12, M102, M280, M241
Europe	R1b1b1a	M412, P310
Europe	R1b1b1a1	L11
Europe	R1b1b1a1a	U106
Europe	R1b1b1a1b	U198, P312, S116
Europe	R1b1b1a1b1	U152
Europe	R1b1b1a1b2	M529
Europe	R1b1b1a1b3,4	M65, M153
Europe	R1b1b1a1b5	SRY2627
South Asia or Melanesia	C1(formerly known as CxC3)	Z1426
North Asia	C2 (formerly known as C3)	M217+
Indonesia or South Asia	F	M89, M282
Europe (Caucasus)	G	M201, M285, P15, P16, M406
South Asia	H	M69, M52, M82, M197, M370
Europe or Middle East	J1	M304, M267, P58, M365, M368, M369
Europe or Middle East	J2	M172, M410, M158, M319, DYS445=6, M339, M340
West of Burma in Eurasia (First Extinction Event?)^[12]
Indonesia (First Extinction Event?)	K2 (NOPS)	M526
South Asia	L	M11, M20, M27, M76, M317, M274, M349, M357
East Asia, South East Asia	N	M231, M214, LLY22g, Tat, M178
East Asia, South East Asia, South Asia	O	M175, M119
Indonesia, Philippines	P (xQR)	92R7, M207, M173, M45
South Asia, Siberia	R and Q (QR) split	MEH2, M242, P36.2, M25, M346
Middle East, Europe, Siberia, South Asia	R1a1	M420, M17, M198, M204, M458
Anatolia, South East Europe ?	R1b	M173, M343, P25, M73
Europe	R1b1b	M269
Europe	R1b1b1	L23
Pakistan, India	R2	M479, M124
Middle East	T	M70
North Africa	E1b1b1	M35
North Africa	E1b1b1a	M78
West Asia	E1b1b1a2	V13
North Africa	E1b1b1a1	V12
North Africa	E1b1b1a1b	V32
North Africa	E1b1b1a3	V22
North Africa	E1b1b1a4	V65
North Africa	E1b1b1b	M81
North Africa	E1b1b1c	M123, M34
West Africa, North Africa	A	M91, M13
East Africa	B	M60, M181, SRY10831.1, M150, M109, M112
Asia, Africa	DE	M1, YAP, M174, M40, M96, M75, M98
East Asia, Nepal	D	M174
West Africa (First Extinction Event?)	E1a	M33
East Africa (First Extinction Event is the split between E1b1 and E1a, second extinction event is the split between E1b1b and E1b1a)	E1b1	P2, M2, U175, M191
Middle East	J1	P58

mtDNA

Origin	Haplogroup
Europe	H1
Europe	H11a
Europe	H1a
Europe	H1b
Europe	H2a
Europe	H3
Europe	H5a
Europe	H6a
Europe	H7
Europe	HV0/HV0a/V
Europe	I4
Europe	J1c7
Europe	J2b1
Europe	T2b*
Europe	T2b4
Europe	T2e
Europe	U4c1
Europe	U5*
Europe	U5a
Europe	U5a1b1
Europe	U5b*
Europe	U5b1b*
Europe	U5b1c
Europe	U5b3
Europe	X2c'e
Middle East	I
Middle East	A
Middle East	B
Middle East	C/Z
Middle East	D/G/M9/E
India	F
Middle East	H*
Middle East	H13a1
Middle East	H14a
Middle East	H20
Middle East	H2a1
Middle East	H4
Middle East	H6b
Middle East	H8
Middle East	HV1
Middle East	I1
Middle East	J / J1c / J2
Middle East	J1a'b'e
Middle East	J1b1a1
Middle East	J1b2a
Middle East	J1d / J2b
Middle East	J1d1
Middle East	J2a
Middle East	J2a2a1
Middle East	K*
Middle East	K1a*
Middle East	K1b1*
Middle East	N1a*
Middle East	N1b
Middle East	N1c
Middle East	N2
Middle East	N9
Middle East	R*
Middle East	R0a
Middle East	T
Middle East	T1*
West Asia	T1a
Middle East	T2
Middle East	T2c
Middle East	T2i
Middle East	U1*
Middle East	U2*
Middle East	U2e
Eurasia	U3*
Middle East	U4
Middle East	U4a*
Middle East	U7
Middle East	U8*
Middle East	U9a
Middle East	X
Middle East	X1a
Middle East	X2b1
North Africa	L3e5
North Africa	M1
North Africa	M1a1
North Africa	U6a
North Africa	U6a1'2'3
North Africa	U6b'c'd
East Africa	L0*
East Africa	L0a1
East Africa	L0a1b
East Africa	L0a2*
East Africa	L3c/L4/M
East Africa	L3d1a1
East Africa	L3d1d
East Africa	L3e1*
East Africa	L3f*
East Africa	L3h1b*
East Africa	L3i*
East Africa	L3x*
East Africa	L4a'b*
East Africa	L5*
East Africa	L6
East Africa	N* / M* / L3*
West Africa	L1b*
West Africa	L1b3
West Africa	L1c*
West Africa	L1c2
West Africa	L2*
West Africa	L2a
West Africa	L2a1*
West Africa	L2a1a2'3'4
West Africa	L2a1b
West Africa	L2a1b'f
West Africa	L2a1c1'2
West Africa	L2a1(16189)
West Africa	L2a2
West Africa	L2b*
West Africa	L2c1'2
West Africa	L2d
West Africa	L2e
West Africa	L3b
West Africa	L3b1a3
West Africa	L3b(16124!)
West Africa	L3b2a
West Africa	L3d*
West Africa	L3e2'3'4
West Africa	L3f1b*

See also

• International HapMap Project
• Molecular evolution
• Molecular phylogenetics
• Human evolutionary genetics
• Race (biology) / Race (human categorization)
• Genetic genealogy
• Genealogical DNA test
• List of genetic genealogy topics
• List of haplogroups of notable people

External links

General

• The Genographic Project

all DNA haplogroups

Y-Chromosome

• World Haplogroups Maps (PDF)

Y chromosome DNA haplogroups

• Y Chromosome Consortium
• ISOGG Y-DNA Haplogroup Tree
• PhyloTree's Y-tree A minimal reference phylogeny for the human Y-chromosome
• Haplogroup Predictor
• The Y Chromosome Consortium (2002), A Nomenclature System for the Tree of Human Y-Chromosomal Binary Haplogroups, Genome Research, Vol. 12(2), 339–48, February 2002. (Detailed hierarchical chart has conversions from previous naming schemes)
• Semino et al. (2000), The Genetic Legacy of Paleolithic Homo sapiens sapiens in Extant Europeans, Science, Vol 290 (paper which introduced the "Eu" haplogroups).
• Y-DNA Ethnographic and Genographic Atlas and Open-Source Data Compilation

Mitochondrial DNA haplogroups

• PhyloTree – The phylogenetic tree of global human mitochondrial DNA variation
• PhyloD3 – D3.js-based phylogenetic tree based on PhyloTree
• MitoTool – a web server for the analysis and retrieval of human mitochondrial DNA sequence variations
• HaploGrep – automatic classification of mitochondrial DNA haplogroups based on PhyloTree
• HaploFind – fast automatic haplogroup assignment pipeline for human mitochondrial DNA
• graphical mtDNA haplogroup skeleton
• The Making of the African mtDNA Landscape
• Do the Four Clades of the mtDNA Haplogroup L2 Evolve at Different Rates?

Software

• Y-DNA Haplogroup Browser

Notes and References

1. Consortium . The Y Chromosome . A Nomenclature System for the Tree of Human Y-Chromosomal Binary Haplogroups . Genome Research . Cold Spring Harbor Laboratory . 12 . 2 . 2002-02-01 . 1088-9051 . 10.1101/gr.217602 . 339–348. 11827954 . 155271 .
2. Web site: Y Chromosome Consortium . 2005-07-27 . https://web.archive.org/web/20170116195823/http://ycc.biosci.arizona.edu/ . 2017-01-16 . dead .
3. G. David . Poznik . Yali . Xue . Fernando L. . Mendez . etal . Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences . . 2016 . 48 . 6 . 593–599 . 10.1038/ng.3559 . 27111036 . 4884158 .
4. Monika . Karmin . Lauri . Saag . Mário . Vicente . etal . 2015 . A recent bottleneck of Y chromosome diversity coincides with a global change in culture . Genome Research . 25 . 4. 459–466 . 10.1101/gr.186684.114 . 25770088 . 4381518 .
5. Rootsi S, Magri C, Kivisild T, Benuzzi G, Help H, Bermisheva M, Kutuev I, Barać L, Pericić M, Balanovsky O, Pshenichnov A, Dion D, Grobei M, Zhivotovsky LA, Battaglia V, Achilli A, Al-Zahery N, Parik J, King R, Cinnioğlu C, Khusnutdinova E, Rudan P, Balanovska E, Scheffrahn W, Simonescu M, Brehm A, Goncalves R, Rosa A, Moisan JP, Chaventre A, Ferak V, Füredi S, Oefner PJ, Shen P, Beckman L, Mikerezi I, Terzić R, Primorac D, Cambon-Thomsen A, Krumina A, Torroni A, Underhill PA, Santachiara-Benerecetti AS, Villems R, Semino O . Phylogeography of Y-chromosome haplogroup I reveals distinct domains of prehistoric gene flow in europe . American Journal of Human Genetics . 75 . 1 . 128–37 . Jul 2004 . 15162323 . 10.1086/422196 . 1181996 . 2007-03-08 . https://web.archive.org/web/20090624135411/http://www.familytreedna.com/pdf/DNA.RootsiHaplogroupISpread.pdf . 2009-06-24 . dead .
6. Web site: PhyloTree.org .
7. Loogväli EL, Roostalu U, Malyarchuk BA, Derenko MV, Kivisild T, Metspalu E, Tambets K, Reidla M, Tolk HV, Parik J, Pennarun E, Laos S, Lunkina A, Golubenko M, Barac L, Pericic M, Balanovsky OP, Gusar V, Khusnutdinova EK, Stepanov V, Puzyrev V, Rudan P, Balanovska EV, Grechanina E, Richard C, Moisan JP, Chaventré A, Anagnou NP, Pappa KI, Michalodimitrakis EN, Claustres M, Gölge M, Mikerezi I, Usanga E, Villems R . 6 . Disuniting uniformity: a pied cladistic canvas of mtDNA haplogroup H in Eurasia . Mol. Biol. Evol. . 21 . 11 . 2012–21 . 2004 . 15254257 . 10.1093/molbev/msh209 . free .
8. Tolk HV, Barac L, Pericic M, Klaric IM, Janicijevic B, Campbell H, Rudan I, Kivisild T, Villems R, Rudan P . The evidence of mtDNA haplogroup F in a European population and its ethnohistoric implications . European Journal of Human Genetics . 9 . 9 . 717–23 . Sep 2001 . 11571562 . 10.1038/sj.ejhg.5200709 . free .
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