Haplogroup T (mtDNA) explained
T |
Origin-Date: | 25,149 ± 4,668 years before present |
Origin-Place: | Near East, and/or Caucasus |
Ancestor: | JT |
Descendants: | T1 and T2 |
Mutations: | G709A, G1888A, A4917G, G8697A, T10463C, G13368A, G14905A, A15607G, G15928A, C16294T |
Haplogroup T is a human mitochondrial DNA (mtDNA) haplogroup. It is believed to have originated around 25,100 years ago in the Near East.
Origins
Mitochondrial clade T derives from the haplogroup JT, which also gave rise to the mtDNA haplogroup J. The T maternal clade is thought to have emanated from the Near East.
Distribution
The basal haplogroup T* is found among Algerians in Oran (1.67%) and Reguibate Sahrawi (0.93%).[1] It is also distributed among the Soqotri (1.2%).[2]
Haplogroup T is present at low frequencies throughout Western and Central Asia and Europe, with varying degrees of prevalence and certainly might have been present in other groups from the surrounding areas. T is found in approximately 10% of native Europeans.[3] [4] It is also common among modern day Iranians. Based on a sample of over 400 modern day Iranians, the T haplogroup represents roughly 8.3% of the population (about 1 out of 12 individuals), with the more specific T1 subtype constituting roughly half of those. Furthermore, the specific subtype T1 tends to be found further east and is common in Central Asian and modern Turkic populations, who inhabit much of the same territory as the ancient Saka, Sarmatian, Andronovo, and other putative Iranian peoples of the 2nd and 1st millennia BC. Lalueza-Fox et al. (2004) also found several T and T1 sequences in ancient burials, including Kurgans, in the Kazakh steppe between the 14th-10th centuries BC, as well as later into the 1st millennia BC. These coincide with the latter part of the Andronovo period and the Saka period in the region.[5]
The geographic distribution within subclade T2 varies greatly with the ratio of subhaplogroup T2e to T2b reported to vary 40-fold across examined populations from a low in Britain and Ireland, to a high in Saudi Arabia . Within subhaplogroup T2e, a very rare motif is identified among Sephardic Jews of Turkey and Bulgaria and suspected conversos from the New World .
Found in Svan population from Caucasus (Georgia) T* 10,4% and T1 4,2%. T1a1a1 is particularly common in countries with high levels of Y-haplogroup R1a, such as Central and Northeast Europe. The clade is also found everywhere in Central Asia and deep into North Asia, as far east as Mongolia.
T2c and T2d appear to have a Near Eastern origin around the time of the Last Glacial Maximum (LGM) and more recent dispersals into Europe. Most of T2c comprises haplogroup T2c1. Apart from a peak in Cyprus, T2c1 is most common in the Persian Gulf region but is also found in the Levant and in Mediterranean Europe, with a more far-flung distribution at very low levels.[6]
T2 is also found among the Soqotri (7.7%).[2]
Archaeology
Wilde et al. (2014) tested mtDNA samples from the Yamna culture, the presumed homeland of Proto-Indo-European speakers. They found T2a1b in the Middle Volga region and Bulgaria, and T1a both in central Ukraine and the Middle Volga. The frequency of T1a and T2 in Yamna samples were each 14.5%, a percentage higher than in any country today and only found in similarly high frequencies among the Udmurts of the Volga-Ural region.[7]
Haplogroup T has also been found among Iberomaurusian specimens dating from the Epipaleolithic at the Afalou prehistoric site in Algeria. One ancient individual carried the T2b subclade (1/9; 11%).[8] Additionally, haplogroup T has been observed among ancient Egyptian mummies excavated at the Abusir el-Meleq archaeological site in Middle Egypt, which date from the Pre-Ptolemaic/late New Kingdom (T1, T2), Ptolemaic (T1, T2), and Roman (undifferentiated T, T1) periods.[9] Fossils excavated at the Late Neolithic site of Kelif el Boroud in Morocco, which have been dated to around 3,000 BCE, have also been observed to carry the T2 subclade.[10] Additionally, haplogroup T has been observed in ancient Guanche fossils excavated in Gran Canaria and Tenerife on the Canary Islands, which have been radiocarbon-dated to between the 7th and 11th centuries CE. The clade-bearing individuals were inhumed at the Tenerife site, with one specimen found to belong to the T2c1d2 subclade (1/7; 14%).[11]
Africa
In Africa, haplogroup T is primarily found among Afro-Asiatic-speaking populations, including the basal T* clade.[1] Some non-basal T clades are also commonly found among the Niger-Congo-speaking Serer due to diffusion from the Maghreb, likely with the spread of Islam.[12]
Population | Location | Language Family | N | Frequency | Source |
---|
Amhara | Ethiopia | Afro-Asiatic > Semitic | 5/120 | 4.17% | |
Beja | Sudan | Afro-Asiatic > Cushitic | 1/48 | 2.1% | |
Beta Israel | Ethiopia | Afro-Asiatic > Cushitic | 0/29 | 0.00% | |
Copt | Egypt | Afro-Asiatic > Egyptian | 5/29 | 17.2% | |
Dawro K. | Ethiopia | Afro-Asiatic > Omotic | 2/137 | 1.46% | and |
Egyptians (El-Hayez) | Egypt | Afro-Asiatic > Semitic | 10/35 | 28.6% | |
Ethiopia | Ethiopia | Undetermined | 2/77 | 2.60% | |
Ethiopian Jew | Ethiopia | Afro-Asiatic > Cushitic | 0/41 | 0.00% | |
Gurage | Ethiopia | Afro-Asiatic > Semitic | 0/21 | 0.00% | |
Hamer | Ethiopia | Afro-Asiatic > Omotic | 0/11 | 0.00% | and |
Ongota | Ethiopia | Afro-Asiatic > Cushitic | 0/19 | 0.00% | and |
Oromo | Ethiopia | Afro-Asiatic > Cushitic | 0/33 | 0.00% | |
Tigrai | Ethiopia | Afro-Asiatic > Semitic | 3/44 | 6.82% | |
Daasanach | Kenya | Afro-Asiatic > Cushitic | 0/49 | 0.00% | |
Elmolo | Kenya | Afro-Asiatic > Cushitic | 0/52 | 0.00% | and |
Luo | Kenya | Nilo-Saharan | 0/49 | 0.00% | and |
Maasai | Kenya | Nilo-Saharan | 0/81 | 0.00% | and |
Nairobi | Kenya | Niger-Congo | 0/100 | 0.00% | |
Nyangatom | Kenya | Nilo-Saharan | 0/112 | 0.00% | |
Rendille | Kenya | Afro-Asiatic > Cushitic | 0/17 | 0.00% | and |
Samburu | Kenya | Nilo-Saharan | 0/35 | 0.00% | and |
Turkana | Kenya | Nilo-Saharan | 0/51 | 0.00% | and |
Hutu | Rwanda | Niger-Congo | 0/42 | 0.00% | |
Dinka | Sudan | Nilo-Saharan | 0/46 | 0.00% | |
Sudan | Sudan | Undetermined | 3/102 | 2.94% | |
Burunge | Tanzania | Afro-Asiatic > Cushitic | 0/38 | 0.00% | |
Datoga | Tanzania | Nilo-Saharan | 1/57 | 1.75% | and |
Iraqw | Tanzania | Afro-Asiatic > Cushitic | 0/12 | 0.00% | |
Sukuma | Tanzania | Niger-Congo | 0/32 | 0.00% | and |
Turu | Tanzania | Niger-Congo | 0/29 | 0.00% | |
Yemeni | Yemen | Afro-Asiatic > Semitic | 1/114 | 0.88% | |
|
Europe
Subclades
Tree
This phylogenetic tree of haplogroup I subclades is based on the paper and subsequent published research . For brevity, only the first three levels of subclades (branches) are shown.
- T
- T1
- T2
- T2a
- T2b
- T2b1
- T2b2
- T2b3
- T2b4
- T2b5
- T2b6
- T2c
- T2d
- T2e
- T2f
- T2g
Health issues
One study has shown Haplogroup T to be associated with increased risk for coronary artery disease. However, some studies have also shown that people of Haplogroup T are less prone to diabetes (and).
A few tentative medical studies have demonstrated that Haplogroup T may offer some resistance to both Parkinson's disease and Alzheimer's disease.
One study has found that among the Spanish population, hypertrophic cardiomyopathy (HCM) also referred to as hypertrophic obstructive cardiomyopathy (HOCM) is more likely to happen in those of T2 ancestry than those in other maternal haplogroups.[13] It is unknown whether or not this is specific to this subclaude of haplogroup T or is a risk factor shared by all of haplogroup T. With a statistically significant difference found in such a small sample, it may be advisable for those of known haplogroup T maternal ancestry to be aware of this and have their physician check for evidence of this condition when having a routine exam at an early age. It is usually symptom-less and increases the risk of sudden cardiac death, which often happens to those of as early in life as teenagers and may affect those who are active and have no other risk factors.[14]
Certain medical studies had shown mitochondrial Haplogroup T to be associated with reduced sperm motility in males, although these results have been challenged . According to the Departamento de Bioquimica y Biologica Molecular y Celular, Universidad de Zaragoza, Haplogroup T can predispose to asthenozoospermia . However, these findings have been disputed due to a small sample size in the study .
Famous members
During the BBC One documentary Meet the Izzards, the actor and comedian Eddie Izzard learns that his mitochondrial DNA is of Haplogroup T, specifically the subclade T2f1a1.[15]
Henry Louis Gates Jr. belongs to haplogroup T2b2.[16]
Nicholas II of Russia
The last Russian Tsar, Nicholas II, has been shown to be of Haplogroup T, specifically subclade T2 . Assuming all relevant pedigrees are correct, this includes all female-line descendants of his female line ancestor Barbara of Celje (1390–1451), wife of Sigismund, Holy Roman Emperor. This includes a great number of European nobles, including George I of Great Britain and Frederick William I of Prussia (through the Electress Sophia of Hanover), Charles I of England, George III of the United Kingdom, George V of the United Kingdom, Charles X Gustav of Sweden, Gustavus Adolphus of Sweden, Maurice of Nassau, Prince of Orange, Olav V of Norway, and George I of Greece.
See also
Backbone mtDNA Tree
References
Citations
- Asmahan Bekada . Lara R. Arauna . Tahria Deba . Francesc Calafell . Soraya Benhamamouch . David Comas . Genetic Heterogeneity in Algerian Human Populations. PLOS ONE. September 24, 2015. 10. 9. 10.1371/journal.pone.0138453. e0138453 . 26402429 . 4581715. 2015PLoSO..1038453B. free .
- S5 Table
- Černý, Viktor. Out of Arabia—the settlement of island Soqotra as revealed by mitochondrial and Y chromosome genetic diversity. American Journal of Physical Anthropology. 2009. 138. 4. 439–447. 13 June 2016. etal. 10.1002/ajpa.20960. 19012329. dead. https://web.archive.org/web/20161006125303/http://ychrom.invint.net/upload/iblock/f30/Cerny%202009%20Out%20of%20ArabiarusThe%20Settlement%20of%20Island%20Soqotra%20as%20Revealed%20by%20Mitochondrial%20and%20Y.pdf. 6 October 2016.
- Book: Bryan Sykes. The Seven Daughters of Eve. 2001. Bantam Press. London; New York. 978-0393020182. The Seven Daughters of Eve. Bryan Sykes.
- Web site: Maternal Ancestry. Oxford Ancestors. 7 February 2013. https://web.archive.org/web/20170715205636/http://www.oxfordancestors.com/content/view/35/55/. 15 July 2017. dead.
- Bennett . Casey . Kaestle . Frederika A. . 2010 . Investigation of Ancient DNA from Western Siberia and the Sargat Culture . Human Biology . 82 . 2. 143–156 . 10.3378/027.082.0202. 20649397 . 1112.2014 . 54566651 .
- Mitochondrial DNA Signals of Late Glacial Recolonization of Europe from Near Eastern Refugia. 4 May 2012. 915–924. 10.1016/j.ajhg.2012.04.003. 90. 5. The American Journal of Human Genetics. 22560092. 3376494 . Pala . M . Olivieri . A . Achilli . A . Accetturo . M . Metspalu . E . Reidla . M . Tamm . E . Karmin . M . Reisberg . T . Hooshiar Kashani . B . Perego . UA . Carossa . V . Gandini . F . Pereira . JB . Soares . P . Angerhofer . N . Rychkov . S . Al-Zahery . N . Carelli . V . Sanati . MH . Houshmand . M . Hatina . J . Macaulay . V . Pereira . L . Woodward . SR . Davies . W . Gamble . C . Baird . D . Semino . O . Villems . R . Torroni . A . Richards . MB. http://haplogroup.org/sources/mitochondrial-dna-signals-of-late-glacial-recolonization-of-europe-from-near-eastern-refugia/
- 10.1073/pnas.1316513111 . 24616518 . 111 . 13 . Direct evidence for positive selection of skin, hair, and eye pigmentation in Europeans during the last 5,000 y . Proceedings of the National Academy of Sciences . 4832–4837 . 2014 . Wilde . Sandra. 3977302 . 2014PNAS..111.4832W . free .
- Kefi, Rym. etal. On the origin of Iberomaurusians: new data based on ancient mitochondrial DNA and phylogenetic analysis of Afalou and Taforalt populations. Mitochondrial DNA Part A. 2018. 29. 1. 147–157. 10.1080/24701394.2016.1258406. 28034339. 4490910.
- Schuenemann, Verena J.. etal. Ancient Egyptian mummy genomes suggest an increase of Sub-Saharan African ancestry in post-Roman periods. Nature Communications. 2017. 8. 15694. 28556824. 10.1038/ncomms15694. 5459999. 2017NatCo...815694S.
- Fregel . etal . 2018 . --> Ancient genomes from North Africa evidence prehistoric migrations to the Maghreb from both the Levant and Europe . 10.1101/191569.
- Rodrı́guez-Varela. etal. Genomic Analyses of Pre-European Conquest Human Remains from the Canary Islands Reveal Close Affinity to Modern North Africans. Current Biology. 2017. 27. 1–7. 10.1016/j.cub.2017.09.059. 29107554. 3396–3402.e5. free. 2164/13526. free.
- Book: Ball. Edward. The Genetic Strand: Exploring a Family History Through DNA. 2007. Simon and Schuster. 233. 978-1416554257. 31 May 2016.
- Castro. M. Mitochondrial DNA haplogroups in Spanish patients with hypertrophic cardiomyopathy. . 16313983. 10.1016/j.ijcard.2005.09.008. 112. 2. 202–6. Int J Cardiol. 2006.
- Web site: Chen. Michael. Hypertrophic cardiomyopathy - Medical Encyclopedia. Medline Plus. National Library of Medicine. 2015-10-03.
- Meet the Izzards: The Mum's Line . . 48 . 2013-03-12.
- Book: Gates Jr., Henry Louis. 4. 2010. Faces of America: How 12 Extraordinary People Discovered Their Pasts. New York University Press.
Sources
- Pike DA, Barton TJ, Bauer SL, Kipp E. mtDNA Haplogroup T Phylogeny Based on Full Mitochondrial Sequences. Journal of Genetic Genealogy. 6. 1. 2010. 2011-10-19. 2016-04-22. https://web.archive.org/web/20160422154847/http://www.jogg.info/62/index.html. dead.
- Malyarchuk . B. A. . Derenko . M. V. . Molecular instability of the mitochondrial haplogroup T sequences at nucleotide positions 16292 and 16296 . Annals of Human Genetics . November 1999 . 63 . 6 . 489–497 . 10.1017/S0003480099007794. 11246451 .
- Abu-Amero. 2008. 10.1186/1471-2148-8-45. 18269758. 2268671. Mitochondrial DNA structure in the Arabian Peninsula. Khaled K. Larruga. José M. Cabrera. Vicente M. González. Ana M. BMC Evolutionary Biology. 8. 1 . 45 . 2008BMCEE...8...45A . free .
- Babalini. 2005. 10.1038/sj.ejhg.5201439. 15886710. The population history of the Croatian linguistic minority of Molise (southern Italy): A maternal view. Carla. Martínez-Labarga. Cristina. Tolk. Helle-Viivi. Kivisild. Toomas. Giampaolo. Rita. Tarsi. Tiziana. Contini. Irene. Barać. Lovorka. Janićijević. Branka. Martinović Klarić. Irena. Peričić. Marijana. Sujoldžić. Anita. Villems. Richard. Biondi. Gianfranco. Rudan. Pavao. Rickards. Olga. European Journal of Human Genetics. 13. 8. 902–12. 8. free.
- Bedford. Felice Bedford. 2012. 22108605. 10.1038/ejhg.2011.200. 3306851. Sephardic signature in haplogroup T mitochondrial DNA. Felice L. European Journal of Human Genetics. 20. 4. 441–8.
- Behar. 2008. . 10.1371/journal.pone.0002062. 18446216. 2323359. DM. Metspalu. E. Kivisild. T. Rosset. S. Tzur. S. Hadid. Y. Yudkovsky. G. Rosengarten. D. Pereira. L. Amorim. A. Kutuev. I. Gurwitz. D. Bonne-Tamir. B. Villems. R. Skorecki. K. Counting the founders: The matrilineal genetic ancestry of the Jewish Diaspora. 3. 4. e2062. PLOS ONE. MacAulay. Vincent. 8. 2008PLoSO...3.2062B. free.
- Behar. 2012. . 10.1016/j.ajhg.2012.03.002. A "Copernican" Reassessment of the Human Mitochondrial DNA Tree from its Root. Doron M.. Van Oven. Mannis. Rosset. Saharon. Metspalu. Mait. Loogväli. Eva-Liis. Silva. Nuno M.. Kivisild. Toomas. Torroni. Antonio. Villems. Richard. The American Journal of Human Genetics. 90. 4. 675–84. 22482806. 3322232.
- Belyaeva. 2003. . 10.1353/hub.2003.0069. 14763602. Mitochondrial DNA variations in Russian and Belorussian populations. Olga. Bermisheva. Marina. Khrunin. Andrey. Slominsky. Petr. Bebyakova. Natalia. Khusnutdinova. E. K. (Elza Kamilevna). Mikulich. Aleksei Ignatevich. Limborskaia. S. A. (Svetlana Andreevna). Human Biology. 75. 5. 647–60. 23876546.
- Boattini. 2013. . 10.1002/ajpa.22212. MtDNA variation in East Africa unravels the history of afro-asiatic groups. Alessio. Castrì. Loredana. Sarno. Stefania. Useli. Antonella. Cioffi. Manuela. Sazzini. Marco. Garagnani. Paolo. De Fanti. Sara. Pettener. Davide. Luiselli. Donata. American Journal of Physical Anthropology. 375–385. 150. 3. 23283748.
- Bosch. 2006. . 10.1111/j.1469-1809.2005.00251.x. Paternal and maternal lineages in the Balkans show a homogeneous landscape over linguistic barriers, except for the isolated Aromuns. E.. Calafell. F.. Gonzalez-Neira. A.. Flaiz. C.. Mateu. E.. Scheil. H.-G.. Huckenbeck. W.. Efremovska. L.. Mikerezi. I.. Xirotiris. N.. Grasa. C.. Schmidt. H.. Comas. D.. Annals of Human Genetics. 70. 4. 459–87. 16759179. 23156886. 8.
- Brandstatter. 2004. . 10.1007/s00414-004-0466-z. Mitochondrial DNA control region sequences from Nairobi (Kenya): Inferring phylogenetic parameters for the establishment of a forensic database. Anita. Peterson. Christine T.. Irwin. Jodi A.. Mpoke. Solomon. Koech. Davy K.. Parson. Walther. Parsons. Thomas J.. International Journal of Legal Medicine. 118. 5. 294–306. 15248073. 19703169.
- Castrì. 2008. . Loredana. Kenyan crossroads: migration and gene flow in six ethnic groups from Eastern Africa. Journal of Anthropological Sciences. 86. 189–192. 19934476. Garagnani. P. Useli. A. Pettener. D. Luiselli. D .
- Castrì. 2009. . 10.1002/ajpa.21070. MtDNA variability in two Bantu-speaking populations (Shona and Hutu) from Eastern Africa: Implications for peopling and migration patterns in sub-Saharan Africa. Loredana. Tofanelli. Sergio. Garagnani. Paolo. Bini. Carla. Fosella. Xenia. Pelotti. Susi. Paoli. Giorgio. Pettener. Davide. Luiselli. Donata. American Journal of Physical Anthropology. 140. 2. 302–11. 19425093.
- . Chinnery. 2007. 10.1136/jmg.2007.048876. 17551080. 2740896. Mitochondrial DNA haplogroups and type 2 diabetes: A study of 897 cases and 1010 controls. P F. Mowbray. C. Patel. S K. Elson. J L. Sampson. M. Hitman. G A. McCarthy. M I. Hattersley. A T. Walker. M. Journal of Medical Genetics. 44. 6. e80.
- Coble. 2009. 10.1371/journal.pone.0004838. 19277206. 2652717. Mystery Solved: The Identification of the Two Missing Romanov Children Using DNA Analysis. Hofreiter. Michael. Michael D.. Loreille. Odile M.. Wadhams. Mark J.. Edson. Suni M.. Maynard. Kerry. Meyer. Carna E.. Niederstätter. Harald. Berger. Cordula. Berger. Burkhard. Falsetti. A. B.. Gill. P. Parson. W. Finelli. L. N.. PLOS ONE. 4. 3. e4838. 8. 2009PLoSO...4.4838C. free.
- Costa. 2009. . 10.1016/j.mad.2008.12.001. 19133286. MD. Cherni. L. Fernandes. V. Freitas. F. Ammar El Gaaied. AB. Pereira. L. Data from complete mtDNA sequencing of Tunisian centenarians: Testing haplogroup association and the "golden mean" to longevity. 130. 4. 222–6. Mechanisms of Ageing and Development. 6102820.
- Cvjetan. 2004. . S. Tolk. HV. Lauc. LB. Colak. I. Dordević. D. Efremovska. L. Janićijević. B. Kvesić. A. Klarić. IM. Metspalu. E. Pericić. M. Parik. J. Popović. D. Sijacki. A. Terzić. R. Villems. R. Rudan. P. Frequencies of mtDNA haplogroups in southeastern Europe--Croatians, Bosnians and Herzegovinians, Serbians, Macedonians and Macedonian Romani. Collegium Antropologicum. 28. 1. 193–8. 15636075. 8.
- Derenko. 2007. . 10.1086/522933. 17924343. M. Malyarchuk. B. Grzybowski. T. Denisova. G. Dambueva. I. Perkova. M. Dorzhu. C. Luzina. F. Lee. HK. Vanecek. Tomas. Villems. Richard. Zakharov. Ilia. Phylogeographic analysis of mitochondrial DNA in northern Asian populations. 81. 5. 1025–41. 2265662. American Journal of Human Genetics. 8.
- Dubut. 2003. . 10.1038/sj.ejhg.5201145. MtDNA polymorphisms in five French groups: Importance of regional sampling. Vincent. Chollet. Lionel. Murail. Pascal. Cartault. François. Béraud-Colomb. Eliane. Serre. Myriam. Mogentale-Profizi. Nérina. European Journal of Human Genetics. 12. 4. 293–300. 14694359. free.
- Fernandes. 2012. . 10.1016/j.ajhg.2011.12.010. The Arabian Cradle: Mitochondrial Relicts of the First Steps along the Southern Route out of Africa. Verónica. Alshamali. Farida. Alves. Marco. Costa. Marta D.. Pereira. Joana B.. Silva. Nuno M.. Cherni. Lotfi. Harich. Nourdin. Cerny. Viktor. Soares. Pedro. Richards. Martin B.. Pereira. Luísa. The American Journal of Human Genetics. 90. 2. 347–355. 8. 22284828. 3276663.
- Finnila. 2001. . 12949126. JS. Finnila. S. Majamaa. K. Lineage-specific selection in human mtDNA: Lack of polymorphisms in a segment of MTND5 gene in haplogroup J. 20. 12. 2132–42. 10.1093/molbev/msg230. Molecular Biology and Evolution. free.
- Gasparre. 2007. . 10.1073/pnas.0703056104. Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors. G.. Porcelli. A. M.. Bonora. E.. Pennisi. L. F.. Toller. M.. Iommarini. L.. Ghelli. A.. Moretti. M.. Betts. C. M.. Martinelli. G. N.. Ceroni. A. R.. Curcio. F.. Carelli. V.. Rugolo. M.. Tallini. G.. Romeo. G.. Proceedings of the National Academy of Sciences. 104. 21. 9001–9006. 8. 17517629. 1885617. 2007PNAS..104.9001G. free.
- Gonder. 2006. 10.1093/molbev/msl209. Whole-mtDNA Genome Sequence Analysis of Ancient African Lineages. M. K.. Mortensen. H. M.. Reed. F. A.. De Sousa. A.. Tishkoff. S. A.. Molecular Biology and Evolution. 24. 3. 757–68. 17194802. free.
- . González. 2012. 10.1089/gtmb.2011.0207. 22480375. 3422557. Genetics, Environment, and Diabetes-Related End-Stage Renal Disease in the Canary Islands. Ana M.. MacEira. Benito M.. Pérez. Estefanía. Cabrera. Vicente M.. López. Alfonso J.. Larruga. José M.. Genetic Testing and Molecular Biomarkers. 16. 8. 859–64.
- Hartmann. 2009. . 10.1002/humu.20816. 18623076. A. Thieme. M. Nanduri. LK. Stempfl. T. Moehle. C. Kivisild. T. Oefner. PJ. Validation of microarray-based resequencing of 93 worldwide mitochondrial genomes. 30. 1. 115–22. Human Mutation. 205918494.
- Web site: Hassan. Hisham Yousif. 2009. Genetic Patterns of Y-chromosome and Mitochondrial DNA Variation, with Implications to the Peopling of the Sudan. University of Khartoum. 2016-04-18. 2020-11-10. https://web.archive.org/web/20201110063820/http://khartoumspace.uofk.edu/handle/123456789/6376/restricted-resource?bitstreamId=11199. dead.
- Helgason. 2001. . 10.1086/318785. mtDNA and the Islands of the North Atlantic: Estimating the Proportions of Norse and Gaelic Ancestry. Agnar. Hickey. Eileen. Goodacre. Sara. Bosnes. Vidar. Stefánsson. Kári. Ward. Ryk. Sykes. Bryan. The American Journal of Human Genetics. 68. 3. 206–15. 1274484. 11179019.
- Hofreiter. 2010. . 10.1371/journal.pone.0011898. The overall occurrence of haplogroups did not deviate from extant Scandinavians, however, haplogroup I was significantly more frequent among the ancient Danes (average 13%) than among extant Danes and Scandinavians (~2.5%) as well as among other ancient population samples reported. Haplogroup I could therefore have been an ancient Southern Scandinavian type “diluted” by later immigration events.. Genetic Diversity among Ancient Nordic Populations. Hofreiter. Michael. Linea. Lynnerup. Niels. Siegismund. Hans R.. Kivisild. Toomas. Dissing. Jørgen. PLOS ONE. 5. 7. e11898. 20689597. 2912848. 2010PLoSO...511898M. free.
- . Ivanov. 1996. 10.1038/ng0496-417. 8630496. Mitochondrial DNA sequence heteroplasmy in the Grand Duke of Russia Georgij Romanov establishes the authenticity of the remains of Tsar Nicholas II. Pavel L.. Wadhams. Mark J.. Roby. Rhonda K.. Holland. Mitchell M.. Weedn. Victor W.. Parsons. Thomas J.. Nature Genetics. 12. 4. 417–20. 287478.
- Janssen. 2006. . 10.1055/s-2006-924066. 16705548. GM. Neu. A. 't Hart. LM. Van De Sande. CM. Antonie Maassen. J. Novel mitochondrial DNA length variants and genetic instability in a family with diabetes and deafness. 114. 4. 168–74. Experimental and Clinical Endocrinology & Diabetes.
- Keyser. 2009. . 10.1007/s00439-009-0683-0. Ancient DNA provides new insights into the history of south Siberian Kurgan people. Christine. Bouakaze. Caroline. Crubézy. Eric. Nikolaev. Valery G.. Montagnon. Daniel. Reis. Tatiana. Ludes. Bertrand. Human Genetics. 126. 3. 395–410. 19449030. 21347353.
- Kivisild. 2004. . 10.1086/425161. 15457403. 1182106. T. Reidla. M. Metspalu. E. Rosa. A. Brehm. A. Pennarun. E. Parik. J. Geberhiwot. T. Usanga. E. Villems. Richard. Ethiopian mitochondrial DNA heritage: Tracking gene flow across and around the gate of tears. 75. 5. 752–70. American Journal of Human Genetics. 8.
- Knight. 2003. . 10.1016/S0960-9822(03)00130-1. 12646128. A. Underhill. PA. Mortensen. HM. Zhivotovsky. LA. Lin. AA. Henn. BM. Louis. D. Ruhlen. M. Mountain. JL. African Y chromosome and mtDNA divergence provides insight into the history of click languages. 13. 6. 464–73. Current Biology. 52862939. free.
- Krings. 1999. . 10.1086/302314. 10090902. 1377841. M. Salem. AE. Bauer. K. Geisert. H. Malek. AK. Chaix. L. Simon. C. Welsby. D. Di Rienzo. A. Utermann. Gerd. Sajantila. Antti. Pääbo. Svante. Stoneking. Mark. MtDNA analysis of Nile River Valley populations: A genetic corridor or a barrier to migration?. 64. 4. 1166–1176. American Journal of Human Genetics. 8.
- 2009. . Martina Kujanova . Luisa Pereira . Veronica Fernandes . Joana B. Pereira . Viktor Cerny . Near Eastern Neolithic Genetic Input in a Small Oasis of the Egyptian Western Desert. American Journal of Physical Anthropology. 140. 2. 336–346. 10.1002/ajpa.21078. 19425100.
- Lalueza-Fox. 2004. . 10.1098/rspb.2004.2698. 15255049. C. Sampietro. ML. Gilbert. MT. Castri. L. Facchini. F. Pettener. D. Bertranpetit. J. Unravelling migrations in the steppe: Mitochondrial DNA sequences from ancient central Asians. 271. 1542. 941–7. 1691686. Proceedings: Biological Sciences.
- Maca-Meyer. . 2001. 10.1186/1471-2156-2-13. 11553319. N. González. AM. Larruga. JM. Flores. C. Cabrera. VM. Major genomic mitochondrial lineages delineate early human expansions. 2. 13. 55343. BMC Genetics . free .
- MacAulay. 1999. . 10.1086/302204. The Emerging Tree of West Eurasian mtDNAs: A Synthesis of Control-Region Sequences and RFLPs. Vincent. Richards. Martin. Hickey. Eileen. Vega. Emilce. Cruciani. Fulvio. Guida. Valentina. Scozzari. Rosaria. Bonné-Tamir. Batsheva. Sykes. Bryan. Torroni. Antonio. The American Journal of Human Genetics. 64. 232–49. 9915963. 1377722. 1. 8.
- Malyarchuk. 1999. 10.1046/j.1469-1809.1999.6360489.x. 11246451. Molecular instability of the mitochondrial haplogroup T sequences at nucleotide positions 16292 and 16296. B. A.. Derenko. M. V.. Annals of Human Genetics. 63. 6. 489–497. 45007072. free.
- Malyarchuk. 2001. . 10.1046/j.1469-1809.2001.6510063.x. Mitochondrial DNA variability in Russians and Ukrainians: Implication to the origin of the Eastern Slavs. B. A.. Derenko. M. V.. Annals of Human Genetics. 65. 63–78. 11415523. Pt 1. 9392520. free.
- Malyarchuk. 2003. . 12940915. BA. Grzybowski. T. Derenko. MV. Czarny. J. Drobnic. K. Miścicka-Sliwka. D. Mitochondrial DNA variability in Bosnians and Slovenians. 67. Pt 5. 412–25. Annals of Human Genetics. 10.1046/j.1469-1809.2003.00042.x. 2105448.
- Malyarchuk. 2010. . 10.1093/molbev/msq065. 20457583. B. Derenko. M. Denisova. G. Kravtsova. O. Mitogenomic diversity in Tatars from the Volga-Ural region of Russia. 27. 10. 2220–6. Molecular Biology and Evolution. free.
- Martinez-Cruz. 2012. . 10.1093/molbev/mss091. Evidence of Pre-Roman Tribal Genetic Structure in Basques from Uniparentally Inherited Markers. B.. Harmant. C.. Platt. D. E.. Haak. W.. Manry. J.. Ramos-Luis. E.. Soria-Hernanz. D. F.. Bauduer. F.. Salaberria. J.. Oyharcabal. B.. Quintana-Murci. L.. Comas. D.. Genographic. Consortium. Molecular Biology and Evolution. 29. 9. 2211–22. 22411853. 8. free. 10261/112478. free.
- Melchior. 2008. . 10.1371/journal.pone.0002214. Evidence of Authentic DNA from Danish Viking Age Skeletons Untouched by Humans for 1,000 Years. Ahmed. Niyaz. Linea. Kivisild. Toomas. Lynnerup. Niels. Dissing. Jørgen. PLOS ONE. 3. 5. e2214. 18509537. 2386972. 2008PLoSO...3.2214M. free.
- Metspalu. 2004. . 10.1186/1471-2156-5-26. Mait. Kivisild. Toomas. Metspalu. Ene. Parik. Jüri. Hudjashov. Georgi. Kaldma. Katrin. Serk. Piia. Karmin. Monika. Behar. Doron M. Gilbert. M Thomas P. Endicott. Phillip. Mastana. Sarabjit. Papiha. Surinder S. Skorecki. Karl. Torroni. Antonio. Villems. Richard. BMC Genetics. 5. 26. 15339343. Most of the extant mtDNA boundaries in south and southwest Asia were likely shaped during the initial settlement of Eurasia by anatomically modern humans. 516768 . free .
- Mikkelsen. 2010. . 10.1016/j.fsigen.2009.07.007. 20457038. Mitochondrial DNA HV1 and HV2 variation in Danes. Martin. Sørensen. Erik. Rasmussen. Erik Michael. Morling. Niels. Forensic Science International: Genetics. 4. 4. e87–8.
- Mishmar. 2003. . 10.1073/pnas.0136972100. 12509511. D. Ruiz-Pesini. E. Golik. P. MacAulay. V. Clark. AG. Hosseini. S. Brandon. M. Easley. K. Chen. E. Brown. M. D.. Sukernik. R. I.. Olckers. A.. Wallace. D. C.. Natural selection shaped regional mtDNA variation in humans. 100. 1. 171–6. 140917. Proceedings of the National Academy of Sciences of the United States of America. 8. 2003PNAS..100..171M. free.
- Musilová. 2011. . 10.1002/ajpa.21522. Population history of the Red Sea-genetic exchanges between the Arabian Peninsula and East Africa signaled in the mitochondrial DNA HV1 haplogroup. Eliška. Fernandes. Verónica. Silva. Nuno M.. Soares. Pedro. Alshamali. Farida. Harich. Nourdin. Cherni. Lotfi. Gaaied. Amel Ben Ammar El. Al-Meeri. Ali. Pereira. Luísa. Černý. Viktor. American Journal of Physical Anthropology. 145. 4. 592–8. 21660931. 8.
- Nikitin. 2009. . 10.3378/027.081.0104. Mitochondrial DNA Sequence Variation in the Boyko, Hutsul, and Lemko Populations of the Carpathian Highlands. Human Biology. Alexey G.. Kochkin. Igor T.. June. Cynthia M.. Willis. Catherine M.. McBain. Ian. Videiko. Mykhailo Y.. 81. 43–58. 19589018. 1. 45791162.
- Non. 2011. . 10.1002/ajpa.21360. 20623605. Mitochondrial DNA reveals distinct evolutionary histories for Jewish populations in Yemen and Ethiopia. Amy L.. Al-Meeri. Ali. Raaum. Ryan L.. Sanchez. Luisa F.. Mulligan. Connie J.. American Journal of Physical Anthropology. 144. 1–10. 1.
- Palanichamy. 2004. . 10.1086/425871. 15467980. MG. Sun. C. Agrawal. S. Bandelt. HJ. Kong. QP. Khan. F. Wang. CY. Chaudhuri. TK. Palla. V. Zhang. Ya-Ping. Phylogeny of mitochondrial DNA macrohaplogroup N in India, based on complete sequencing: Implications for the peopling of South Asia. 75. 6. 966–78. 1182158. American Journal of Human Genetics. 8.
- Pereira. 2007. . 10.1093/molbev/msm004. 17218641. L. Gonçalves. J. Franco-Duarte. R. Silva. J. Rocha. T. Arnold. C. Richards. M. MacAulay. V. No evidence for an mtDNA role in sperm motility: Data from complete sequencing of asthenozoospermic males. 24. 3. 868–74. Molecular Biology and Evolution. free.
- Pericić. 2005. . 16100752. M. Barać Lauc. L. Martinović Klarić. I. Janićijević. B. Rudan. P. Review of Croatian genetic heritage as revealed by mitochondrial DNA and Y chromosomal lineages. 46. 4. 502–13. Croatian Medical Journal.
- Pichler. 2010. . 10.1038/ejhg.2009.172. 19844259. Drawing the history of the Hutterite population on a genetic landscape: Inference from Y-chromosome and mtDNA genotypes. Irene. Fuchsberger. Christian. Platzer. Christa. Çalişkan. Minal. Marroni. Fabio. Pramstaller. Peter P. Ober. Carole. European Journal of Human Genetics. 18. 4. 463–70. 2987252.
- Poloni. 2009. . 10.1111/j.1469-1809.2009.00541.x. 19706029. Genetic Evidence for Complexity in Ethnic Differentiation and History in East Africa. Estella S.. Naciri. Yamama. Bucho. Rute. Niba. Régine. Kervaire. Barbara. Excoffier. Laurent. Langaney. André. Sanchez-Mazas. Alicia. Annals of Human Genetics. 73. 6. 582–600. 2488794.
- Pope. 2011. . 10.1139/G10-102. 21326367. AM. Carr. SM. Smith. KN. Marshall. HD. Mitogenomic and microsatellite variation in descendants of the founder population of Newfoundland: High genetic diversity in an historically isolated population. 54. 2. 110–9. Genome. Marshall. H. D..
- Quintana-Murci. 2004. . 10.1086/383236. Where West Meets East: The Complex mtDNA Landscape of the Southwest and Central Asian Corridor. Lluís. Chaix. Raphaëlle. Wells. R. Spencer. Behar. Doron M.. Sayar. Hamid. Scozzari. Rosaria. Rengo. Chiara. Al-Zahery. Nadia. Semino. Ornella. Santachiara-Benerecetti. A. Silvana. Coppa. Alfredo. Ayub. Qasim. Mohyuddin. Aisha. Tyler-Smith. Chris. Qasim Mehdi. S.. Torroni. Antonio. McElreavey. Ken. The American Journal of Human Genetics. 74. 5. 827–45. 15077202. 1181978. 8.
- Richards. 2000. . 10.1016/S0002-9297(07)62954-1. Tracing European Founder Lineages in the Near Eastern mtDNA Pool. Martin. MacAulay. Vincent. Hickey. Eileen. Vega. Emilce. Sykes. Bryan. Guida. Valentina. Rengo. Chiara. Sellitto. Daniele. Cruciani. Fulvio. Kivisild. Toomas. Villems. Richard. Thomas. Mark. Rychkov. Serge. Rychkov. Oksana. Rychkov. Yuri. Gölge. Mukaddes. Dimitrov. Dimitar. Hill. Emmeline. Bradley. Dan. Romano. Valentino. Calì. Francesco. Vona. Giuseppe. Demaine. Andrew. Papiha. Surinder. Triantaphyllidis. Costas. Stefanescu. Gheorghe. Hatina. Jiři. Belledi. Michele. Di Rienzo. Anna. Novelletto. Andrea. The American Journal of Human Genetics. 67. 5. 1251–76. 11032788. 1288566. 8.
- Richards. 2003. . 10.1086/374384. Extensive Female-Mediated Gene Flow from Sub-Saharan Africa into Near Eastern Arab Populations. Martin. Rengo. Chiara. Cruciani. Fulvio. Gratrix. Fiona. Wilson. James F.. Scozzari. Rosaria. MacAulay. Vincent. Torroni. Antonio. The American Journal of Human Genetics. 72. 4. 1058–64. 12629598. 1180338.
- Rogaev. 2009. 10.1073/pnas.0811190106. 19251637. 2664067. Genomic identification in the historical case of the Nicholas II royal family. E. I.. Grigorenko. A. P.. Moliaka. Y. K.. Faskhutdinova. G.. Goltsov. A.. Lahti. A.. Hildebrandt. C.. Kittler. E. L. W.. Morozova. I.. Proceedings of the National Academy of Sciences. 106. 13. 5258–63. 2009PNAS..106.5258R. free.
- . Ruiz-Pesini. 2000. 10.1086/303040. 10936107. 1287528. Human mtDNA Haplogroups Associated with High or Reduced Spermatozoa Motility. Eduardo. Lapeña. Ana-Cristina. Díez-Sánchez. Carmen. Pérez-Martos. Acisclo. Montoya. Julio. Alvarez. Enrique. Díaz. Miguel. Urriés. Antonio. Montoro. Luis. López-Pérez. Manuel J.. Enríquez. José A.. The American Journal of Human Genetics. 67. 3. 682–96. 8.
- Shlush. 2008. . 10.1371/journal.pone.0002105. The Druze: A Population Genetic Refugium of the Near East. Gemmell. Neil John. Liran I.. Behar. Doron M.. Yudkovsky. Guennady. Templeton. Alan. Hadid. Yarin. Basis. Fuad. Hammer. Michael. Itzkovitz. Shalev. Skorecki. Karl. PLOS ONE. 3. 5. e2105. 18461126. 2324201. 2008PLoSO...3.2105S. free.
- Soares. 2011. . 10.1093/molbev/msr245. The Expansion of mtDNA Haplogroup L3 within and out of Africa. P.. Alshamali. F.. Pereira. J. B.. Fernandes. V.. Silva. N. M.. Afonso. C.. Costa. M. D.. Musilova. E.. MacAulay. V.. Richards. M. B.. Cerny. V.. Pereira. L.. Molecular Biology and Evolution. 29. 3. 915–27. 22096215. 8. free.
- Stanger. 2007. 10.1016/j.mito.2007.08.034. 30 Mitochondrial haplogroup T is associated with coronary artery disease. Olaf. Müller. Edith. Zimmermann. Franz. Wiesbauer. Martina. Mayr. Johannes A.. Paulweber. Bernhard. Iglseder. Bernhard. Renner. Wilfried. Eder. Waltraud. Kofler. Barbara. Mitochondrion. 7. 6. 412. 8.
- Stone. 2001. 10.1520/JFS14932J. 11210907. AC. Starrs. JE. Stoneking. M. Mitochondrial DNA analysis of the presumptive remains of Jesse James. 46. 1. 173–6. Journal of Forensic Sciences.
- Terreros. 2011. . 10.1038/jhg.2010.174. Mitochondrial DNA and Y-chromosomal stratification in Iran: Relationship between Iran and the Arabian Peninsula. Maria C. Rowold. Diane J. Mirabal. Sheyla. Herrera. Rene J. Journal of Human Genetics. 56. 3. 235–46. 21326310. free.
- Thomas. 2008. 10.1038/sj.ejhg.5201906. 17712356. New genetic evidence supports isolation and drift in the Ladin communities of the South Tyrolean Alps but not an ancient origin in the Middle East. Mark G. Barnes. Ian. Weale. Michael E. Jones. Abigail L. Forster. Peter. Bradman. Neil. Pramstaller. Peter P. European Journal of Human Genetics. 16. 124–34. 1. free.
- Tishkoff. 2007. . 10.1093/molbev/msm155. 17656633. History of Click-Speaking Populations of Africa Inferred from mtDNA and Y Chromosome Genetic Variation. S. A.. Gonder. M. K.. Henn. B. M.. Mortensen. H.. Knight. A.. Gignoux. C.. Fernandopulle. N.. Lema. G.. Nyambo. T. B.. Ramakrishnan. U.. Reed. F. A.. Mountain. J. L.. Molecular Biology and Evolution. 24. 10. 2180–95. 8. free.
- Topf. 2005. . 10.1093/molbev/msj013. Tracing the Phylogeography of Human Populations in Britain Based on 4th-11th Century mtDNA Genotypes. A. L.. Molecular Biology and Evolution. 23. 152–61. 16151183. Gilbert. MT. Dumbacher. JP. Hoelzel. AR. 1. free.
- Torroni. 1996. . Classification of European mtDNAs From an Analysis of Three European Populations. Genetics. 8978068. A. Huoponen. K. Francalacci. P. Petrozzi. M. Morelli. L. Scozzari. R. Obinu. D. Savontaus. ML. Wallace. DC. 144. 4. 1835–50. 10.1093/genetics/144.4.1835. 1207732.
- van Oven. 2009. . 10.1002/humu.20921. Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation. Mannis. Kayser. Manfred. Human Mutation. 30. 2. E386–94. 18853457. 27566749. free.
Websites
- Web site: Behar. Family Tree DNA. 2012. . mtDNA Community. 2013-01-12. 2018-01-02. https://web.archive.org/web/20180102091357/http://www.mtdnacommunity.org/human-mtdna-phylogeny.aspx. dead.
Further reading
- Černý. 2009. . 10.1002/ajpa.20960. Out of Arabia-The settlement of Island Soqotra as revealed by mitochondrial and Y chromosome genetic diversity. Viktor. Pereira. Luísa. Kujanová. Martina. VašÍková. Alžběta. Hájek. Martin. Morris. Miranda. Mulligan. Connie J.. American Journal of Physical Anthropology. 138. 4. 439–47. 19012329.
- Kitchen. 2009. 10.1098/rspb.2009.0408. Bayesian phylogenetic analysis of Semitic languages identifies an Early Bronze Age origin of Semitic in the Near East. A.. Ehret. C.. Assefa. S.. Mulligan. C. J.. Proceedings of the Royal Society B: Biological Sciences. 276. 1668. 2703–10. 19403539. 2839953.
- Petit-Maire. 2000. 10.18814/epiiugs/2000/v23i4/001. Geological records of the recent past, a key to the near future world environments. Nicole. Episodes. 23. 4. 230–246. Bouysse. Philippe. free.
External links