Hamayne Explained

Hamayne is an alkaloid present in plants of the family Amaryllidaceae, including Iberian Narcissus species and two Nigerian Crinum species, reported to have acetylcholinesterase inhibitory activity.[1] The product has been made via total synthesis as well.[2]

Notes and References

  1. López. Susana. Bastida. Jaume. Viladomat. Francesc. Codina. Carles. Acetylcholinesterase inhibitory activity of some Amaryllidaceae alkaloids and Narcissus extracts. Life Sciences. 2002. 71. 21. 2521–2529. 10.1016/S0024-3205(02)02034-9. 12270757.
  2. Petit. Laurent. Banwell. Martin G.. Willis. Anthony C.. The Total Synthesis of the Crinine Alkaloid Hamayne via a Pd[0]-Catalyzed Intramolecular Alder-Ene Reaction. Organic Letters. 2011. 13. 21. 5800–5803. 10.1021/ol2023938. 21970722.

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