Haloxazolam Explained

Haloxazolam (marketed in Japan under the brand name Somelin), is a drug which is a benzodiazepine derivative.^{[1] [2] [3]} It has similar hypnotic properties as the benzodiazepine drugs triazolam, temazepam, and flunitrazepam and as such is indicated for the treatment of insomnia.^[4] A study in cats comparing estazolam and haloxazolam found that haloxazolam only affects gamma motor neurons, whereas estazolam affects both alpha and gamma motor neurons.^[5]

See also

• Benzodiazepine

Notes and References

1. Tanaka E, Terada M, Misawa S, Wakasugi C . Simultaneous determination of twelve benzodiazepines in human serum using a new reversed-phase chromatographic column on a 2-microns porous microspherical silica gel . Journal of Chromatography B: Biomedical Sciences and Applications . 682 . 1 . 173–8 . June 1996 . 8832439 . 10.1016/0378-4347(96)00121-1 .
2. Web site: Benzodiazepine Names. 2009-04-05. non-benzodiazepines.org.uk. dead. https://web.archive.org/web/20081208054743/http://www.non-benzodiazepines.org.uk/benzodiazepine-names.html. 2008-12-08.
3. Guan F, Seno H, Ishii A, Watanabe K, Kumazawa T, Hattori H, Suzuki O . Solid-phase microextraction and GC-ECD of benzophenones for detection of benzodiazepines in urine . Journal of Analytical Toxicology . 23 . 1 . 54–61 . 1999 . 10022210 . 10.1093/jat/23.1.54 . free .
4. Tan X, Uchida S, Matsuura M, Nishihara K, Kojima T . Long-, intermediate- and short-acting benzodiazepine effects on human sleep EEG spectra . Psychiatry and Clinical Neurosciences . 57 . 1 . 97–104 . February 2003 . 12519461 . 10.1046/j.1440-1819.2003.01085.x . 20863635 . free .
5. Sakai Y . Comparative study on the effects of haloxazolam and estazolam, new sleep inducing drugs, on the alpha- and gamma-motor systems . Japanese Journal of Pharmacology . 33 . 5 . 1017–25 . October 1983 . 6139494 . 10.1254/jjp.33.1017 . free .