Haloprogesterone Explained

Haloprogesterone, sold under the brand name Prohalone, is a progestin medication which was previously marketed by Ayerst but is now no longer available.^{[1] [2] [3]}

Chemistry

See also: List of progestogens.

Haloprogesterone, also known as 6α-fluoro-17α-bromoprogesterone or as 6α-fluoro-17α-bromopregn-4-ene-3,20-dione, is a synthetic pregnane steroid and a halogenated derivative of progesterone. It is specifically a derivative of 17α-bromoprogesterone and is similar structurally to medrogestone (6-dehydro-6,17α-dimethylprogesterone), medroxyprogesterone acetate (6α-methyl-17α-acetoxyprogesterone), and various other progestins derived from progesterone.

Synthesis

Chemical syntheses of haloprogesterone have been published.^[4]

History

Haloprogesterone was synthesized in 1960 and was introduced for medical use by 1961.^{[5] [6]}

Society and culture

Generic names

Haloprogesterone is the generic name of the drug and its and .

Brand names

Haloprogesterone was marketed under the brand name Prohalone.

Notes and References

1. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 620–.
2. Book: American Pharmaceutical Association. APhA drug names: an index of drug names. 1976. American Pharmaceutical Association. 9780917330094.
3. Book: United States Adopted Names (USAN).. 1968. United States Pharmacopeial Convention.. 715.
4. Book: Die Gestagene. 27 November 2013. Springer-Verlag. 978-3-642-99941-3. 9–10.
5. Book: Official Gazette of the United States Patent Office. 1961. The Office. 74.
6. Book: The Journal of New Drugs. 1962. 127.