Haematopoietic system explained

Haematopoietic system
Function:Creation of the cells of blood

The haematopoietic system is the system in the body involved in the creation of the cells of blood.[1]

Structure

Stem cells

See main article: Hematopoietic stem cell. Haematopoietic stem cells (HSCs) reside in the medulla of the bone (bone marrow) and have the unique ability to give rise to all of the different mature blood cell types and tissues.[2] HSCs are self-renewing cells: when they differentiate, at least some of their daughter cells remain as HSCs, so the pool of stem cells is not depleted. This phenomenon is called asymmetric division.[3] The other daughters of HSCs (myeloid and lymphoid progenitor cells) can follow any of the other differentiation pathways that lead to the production of one or more specific types of blood cell, but cannot renew themselves. The pool of progenitors is heterogeneous and can be divided into two groups; long-term self-renewing HSC and only transiently self-renewing HSC, also called short-terms.[4] This is one of the main vital processes in the body.

Development

In developing embryos, blood formation occurs in aggregates of blood cells in the yolk sac, called blood islands. As development progresses, blood formation occurs in the spleen, liver and lymph nodes. When bone marrow develops, it eventually assumes the task of forming most of the blood cells for the entire organism. However, maturation, activation, and some proliferation of lymphoid cells occurs in the spleen, thymus, and lymph nodes. In children, haematopoiesis occurs in the marrow of the long bones such as the femur and tibia. In adults, it occurs mainly in the pelvis, cranium, vertebrae, and sternum.[5]

Function

See main article: Haematopoeisis. Haematopoiesis (from Greek αἷμα, "blood" and ποιεῖν "to make"; also hematopoiesis in American English; sometimes also haemopoiesis or hemopoiesis) is the formation of blood cellular components. All cellular blood components are derived from haematopoietic stem cells.[6] In a healthy adult person, approximately 1011–1012 new blood cells are produced daily in order to maintain steady state levels in the peripheral circulation.[7] [8]

All blood cells are divided into three lineages.[9]

Clinical significance

Stem cell transplant

See main article: stem cell transplant. A stem cell transplant is a transplant intended to replace the progenitor haematopoietic stem cells

Haematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent haematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood.[10] [11] [12] It may be autologous (the patient's own stem cells are used), allogeneic (the stem cells come from a donor) or syngeneic (from an identical twin).[10] [11]

It is most often performed for patients with certain cancers of the blood or bone marrow, such as multiple myeloma or leukemia.[11] In these cases, the recipient's immune system is usually destroyed with radiation or chemotherapy before the transplantation. Infection and graft-versus-host disease are major complications of allogeneic HSCT.[11]

Haematopoietic stem cell transplantation remains a dangerous procedure with many possible complications; it is reserved for patients with life-threatening diseases. As survival following the procedure has increased, its use has expanded beyond cancer to autoimmune diseases[13] [14] and hereditary skeletal dysplasias; notably malignant infantile osteopetrosis[15] [16] and mucopolysaccharidosis.[17]

Notes and References

  1. Web site: hematopoietic system . Merriam-Webster . 8 July 2019.
  2. Monga I, Kaur K, Dhanda S. Revisiting hematopoiesis: applications of the bulk and single-cell transcriptomics dissecting transcriptional heterogeneity in hematopoietic stem cells . Briefings in Functional Genomics . 21 . 3 . 159–176 . March 2022 . 35265979 . 10.1093/bfgp/elac002.
  3. Morrison. J.. Judith Kimble. Asymmetric and symmetric stem-cell divisions in development and cancer. 10.1038/nature04956. 16810241. Nature. 441. 7097. 1068–74. 2006. 2006Natur.441.1068M. 2027.42/62868. 715049. free.
  4. Morrison. SJ. Weissman, IL. The long-term repopulating subset of hematopoietic stem cells is deterministic and isolable by phenotype.. Immunity. Nov 1994. 1. 8. 661–73. 7541305. 10.1016/1074-7613(94)90037-x.
  5. Fernández. KS. de Alarcón, PA. Development of the hematopoietic system and disorders of hematopoiesis that present during infancy and early childhood.. Pediatric Clinics of North America. Dec 2013. 60. 6. 1273–89. 24237971. 10.1016/j.pcl.2013.08.002.
  6. Birbrair. Alexander. Frenette. Paul S.. 2016-03-01. Niche heterogeneity in the bone marrow. Annals of the New York Academy of Sciences. en. 82–96. 10.1111/nyas.13016. 1749-6632. 1370. 1. 27015419. 4938003. 2016NYASA1370...82B.
  7. Semester 4 medical lectures at Uppsala University 2008 by Leif Jansson
  8. Book: Parslow, T G. . Stites, DP. . Terr, AI. . Imboden JB. . Medical Immunology . 1997 . 1 . 978-0-8385-6278-9.
  9. Web site: Hematopoiesis from Pluripotent Stem Cells. ThermoFisher Scientific. 3 February 2014.
  10. Felfly . H . Haddad . GG . Hematopoietic stem cells: potential new applications for translational medicine . Journal of Stem Cells . 2014 . 9 . 3 . 163–97 . 25157450.
  11. Park . B . Yoo . KH . Kim . C . Hematopoietic stem cell expansion and generation: the ways to make a breakthrough . Blood Research . December 2015 . 50 . 4 . 194–203 . 26770947 . 10.5045/br.2015.50.4.194 . 4705045.
  12. Mahla RS. Stem cells application in regenerative medicine and disease threpeutics . International Journal of Cell Biology . 2016 . 7 . 1–24 . 2016 . 27516776 . 10.1155/2016/6940283 . 4969512 . free .
  13. Tyndall A, Fassas A, Passweg J, etal . Autologous haematopoietic stem cell transplants for autoimmune disease–feasibility and transplant-related mortality. Autoimmune Disease and Lymphoma Working Parties of the European Group for Blood and Marrow Transplantation, the European League Against Rheumatism and the International Stem Cell Project for Autoimmune Disease . Bone Marrow Transplant . 24 . 7 . 729–34 . 1999 . 10516675 . 10.1038/sj.bmt.1701987.
  14. Burt RK, Loh Y, Pearce W, etal . Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases . JAMA . 299 . 8 . 925–36 . 2008 . 18314435 . 10.1001/jama.299.8.925. free .
  15. EL-Sobky . Tamer Ahmed . El-Haddad . Alaa . Elsobky . Ezzat . Elsayed . Solaf M. . Sakr . Hossam Moussa . Reversal of skeletal radiographic pathology in a case of malignant infantile osteopetrosis following hematopoietic stem cell transplantation . The Egyptian Journal of Radiology and Nuclear Medicine . March 2017 . 48 . 1 . 237–43 . 10.1016/j.ejrnm.2016.12.013 . free . vanc.
  16. Hashemi Taheri . Amir Pejman . Radmard . Amir Reza . Kooraki . Soheil . Behfar . Maryam . Pak . Neda . Hamidieh . Amir Ali . Ghavamzadeh . Ardeshir . Radiologic resolution of malignant infantile osteopetrosis skeletal changes following hematopoietic stem cell transplantation . Pediatric Blood & Cancer . September 2015 . 62 . 9 . 1645–49 . 10.1002/pbc.25524 . 25820806 . 11287381 . vanc.
  17. Langereis . Eveline J. . den Os . Matthijs M. . Breen . Catherine . Jones . Simon A. . Knaven . Olga C. . Mercer . Jean . Miller . Weston P. . Kelly . Paula M. . Kennedy . Jim . Ketterl . Tyler G. . O'Meara . Anne . Orchard . Paul J. . Lund . Troy C. . van Rijn . Rick R. . Sakkers . Ralph J. . White . Klane K. . Wijburg . Frits A. . Progression of Hip Dysplasia in Mucopolysaccharidosis Type I Hurler After Successful Hematopoietic Stem Cell Transplantation . The Journal of Bone and Joint Surgery . March 2016 . 98 . 5 . 386–95 . 10.2106/JBJS.O.00601 . 26935461 . vanc.

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