Gymnema sylvestre explained

Gymnema sylvestre[1] is a perennial woody vine native to Asia (including the Arabian Peninsula), Africa and Australia. It has been used in Ayurvedic medicine. Common names include gymnema,[2] Australian cowplant, and Periploca of the woods, and the Hindi term gurmar, which means "sugar destroyer".[3] [4] [5]

The leaves and extracts contain gymnemic acids, the major bioactive constituents that interact with taste receptors on the tongue to temporarily suppress the taste of sweetness.[6] [7] [8] [9] [10]

Description

The plant is a climber with leaves having soft hairs on the upper surface. The leaves are elongated-oval in shape. It has a small, yellow, umbelliferous inflorescence that is produced throughout the year.[11]

Properties

Gymnema sylvestre has a long history of use in herbal medicine and a broad range of therapeutic properties.[12]

Blocks sweet taste sensations

Its leaves contain triterpenoid saponins,[13] [14] [15] flavonols,[16] and gurmarin. The major biologically active plant molecules are gymnemic acids, a class of triterpenoid saponins, which have the effect of suppressing the taste of sweetness on the tongue from sucrose (sugar), stevia, xylitol, and artificial sweeteners such as aspartame.[17]

The sweet-blocking effect of G. sylvestre lasts from 15 to 50 minutes[18] and may even persist for several hours.[19] Gymnemic acids apparently have no long-term effects on taste and they do not influence bitter, salty, or sour taste perception.[20]

Effects on sugar absorption and insulin secretion

Gymnemic acid compounds in Gymnema sylvestre can also attach to receptors on the intestinal walls, helping to reduce absorption of sugar molecules in the gut.[21] This process can lower blood sugar and promote insulin secretion and release.[21] However, its antidiabetic properties were not confirmed in rats.[22]

Uses

  1. Reduction of sugar intake: G. sylvestre extracts taken in the form of lozenges, mouthwash, or tea diminishes the consumption of sweet foods and overall caloric intake. Extracts (formulated as a mint lozenge) reduced the desire for high-sugar foods and the pleasant taste of candy.[23] Research also suggests that Gymnema sylvestre extracts reduce cravings for sugar. In a double-blind study, participants who received a gymnemic acid lozenge declined candy (before tasting it) more often than the placebo group.[24]
  2. Weight loss: In Japan, 50 tons of G. sylvestre leaves are consumed annually for the purpose of weight loss.[25] [26] Early research suggests that taking a specific combination of Gymnema sylvestre extract, hydroxycitric acid, and niacin-bound chromium by mouth for 8 weeks might reduce body weight in people who are overweight or obese.[27]
  3. Traditional uses: In Eastern and Ayurvedic medicine, G. sylvestre leaves and extracts have been used to treat eye diseases, allergies, constipation, cough, dental caries, obesity, stomach ailments, and viral infections. G. sylvestre has also been used as an antioxidant, antimicrobial, and aphrodisiac.

Etymology

Gymnema derives from the Greek words gymnos (γυμνὀς) and nēma (νῆμα) meaning "naked" and "thread", respectively; the species epitheton sylvestre means "of the forest" in Latin.[28]

The Hindi and Urdu name gurmar, Sanskrit मधुनाशिनी (madhunashini), Malayalam chakkarakolli, Tamil சிறுகுறுஞ்சான்,and Telugu పొడపత్రి (podapatri), all literally mean "sugar destroyer". (Sanskrit) meshashringi translates as "ram's horn", a name given to the plant due to the shape of its fruits.

Further reading

Notes and References

  1. Web site: Integrated Taxonomic Information System. www.itis.gov. 2018-02-01.
  2. Book: Handbook of medicinal herbs . 855 . James A. . Duke . vanc . 2nd . CRC Press . 2002 . 978-0-8493-1284-7 .
  3. Book: Quattrocchi, Umberto . CRC World Dictionary of Plant Names: Common Names, Scientific Names, Eponyms, Synonyms, and Etymology. vanc . 1999-11-23. Taylor & Francis US. 978-0849326769. en.
  4. Tiwari P, Mishra BN, Sangwan NS . Phytochemical and pharmacological properties of Gymnema sylvestre: an important medicinal plant . BioMed Research International . 2014 . 830285 . 2014 . 24511547 . 3912882 . 10.1155/2014/830285 . free .
  5. Ulbricht C, Abrams TR, Basch E, Davies-Heerema T, Foppa I, Hammerness P, Rusie E, Tanguay-Colucci S, Taylor S, Ulbricht C, Varghese M, Weissner W, Woods J . An evidence-based systematic review of gymnema (Gymnema sylvestre R. Br.) by the Natural Standard Research Collaboration . Journal of Dietary Supplements . 8 . 3 . 311–30 . 2011 . 22432729 . 10.3109/19390211.2011.597977 . 29228955 .
  6. Kurihara Y . Antisweet activity of gymnemic acid A1 and its derivatives . Life Sciences . 8 . 9 . 537–43 . 1969 . 5791706 . 10.1016/0024-3205(69)90449-4 .
  7. Gent JF, Hettinger TP, Frank ME, Marks LE . Taste confusions following gymnemic acid rinse . Chemical Senses . 24 . 4 . 393–403 . 1999 . 10480675 . 10.1093/chemse/24.4.393 . free .
  8. Sanematsu K, Kusakabe Y, Shigemura N, Hirokawa T, Nakamura S, Imoto T, Ninomiya Y . Molecular mechanisms for sweet-suppressing effect of gymnemic acids . The Journal of Biological Chemistry . 289 . 37 . 25711–20 . September 2014 . 25056955 . 4162174 . 10.1074/jbc.M114.560409 . free .
  9. Book: American Herbal Products Association's Botanical Safety Handbook, Second Edition. Gardner. Zoë. McGuffin. Michael . vanc . 2013. CRC Press. 978-1466516946. en.
  10. Brala PM, Hagen RL . Effects of sweetness perception and caloric value of a preload on short term intake . Physiology & Behavior . 30 . 1 . 1–9 . January 1983 . 6836034 . 10.1016/0031-9384(83)90030-6 . 21639511 .
  11. Book: Drury, Heber . Hand-book of Indian Flora . vanc . Trabancore Sircar Press . 1869 . 978-1-143-66359-8 . Madras . 232 .
  12. Yeh GY, Eisenberg DM, Kaptchuk TJ, Phillips RS . Systematic review of herbs and dietary supplements for glycemic control in diabetes . Diabetes Care . 26 . 4 . 1277–94 . April 2003 . 12663610 . 10.2337/diacare.26.4.1277 . free .
  13. Dateo GP, Long L . Gymnemic acid, the antisaccharine principle of Gymnema sylvestre. Studies on the isolation and heterogeneity of gymnemic acid A1 . Journal of Agricultural and Food Chemistry . 21 . 5 . 899–903 . September 1973 . 4733385 . 10.1021/jf60189a030 .
  14. Di Fabio G, Romanucci V, Di Marino C, Pisanti A, Zarrelli A . Gymnema sylvestre R. Br., an Indian medicinal herb: traditional uses, chemical composition, and biological activity . Current Pharmaceutical Biotechnology . 16 . 6 . 506–16 . 2015 . 25860062 . 10.2174/138920101606150407112903 .
  15. Sinsheimer JE, McIlhenny HM . Constituents from Gymnema sylvestre leaves. II. Nitrogenous compounds . Journal of Pharmaceutical Sciences . 56 . 6 . 732–6 . 1967 . 6039815 . 10.1002/jps.2600560615 .
  16. Liu X, Ye W, Yu B, Zhao S, Wu H, Che C . Two new flavonol glycosides from Gymnema sylvestre and Euphorbia ebracteolata . en . Carbohydrate Research . 339 . 4 . 891–5 . March 2004 . 14980834 . 10.1016/j.carres.2003.12.017 .
  17. Frank . Robert A. . Mize . Sara J.S. . Kennedy . Linda M. . de los Santos . Hannah C. . Green . Sharon J. . vanc . 1992-10-01. The effect of Gymnema sylvestre extracts on the sweetness of eight sweeteners . Chemical Senses . 17 . 5 . 461–479 . 10.1093/chemse/17.5.461 .
  18. Meiselman HL, Halperin BP . Human judgments of Gymnema sylvestre and sucrose mixtures . Physiology & Behavior . 5 . 8 . 945–8 . 1970 . 5522511 . 10.1016/0031-9384(70)90187-3 .
  19. US . 2004071801 . application . Herbal formulation of Gymnema sylvestre as a dietary aid . 15 April 2004 . 9 October 2002 . 9 October 2002 . Edell D, Handel R .
  20. Riskey. Dwight R.. Desor. J. A.. Vellucci. Dominic. vanc . 1982-01-01. Effects of gymnemic acid concentration and time since exposure on intensity of simple tastes: A test of the biphasic model for the action of gymnemic acid. Chemical Senses. en. 7. 2. 143–152. 10.1093/chemse/7.2.143. 0379-864X.
  21. Phytochemical and pharmacological properties of Gymnema sylvestre: an important medicinal plant. . BioMed Research International . 6 January 2002 . 24511547 . 10.1155/2014/830285 . 3912882 . 2014 . 830285 . Tiwari . P . Mishra . BN . Sangwan . NS. free .
  22. Absence of antidiabetic and hypolipidemic effect of Gymnema sylvestre in non-diabetic and alloxan-diabetic rats . Braz. Arch. Biol. Technol. . August 2004 . 10.1590/S1516-89132004000400007 . 47 . 4 . 545–551 . Galletto . R . Siqueira . VLD . Ferreira . EB. free .
  23. Web site: Two clinical studies confirm that Sweet Defeat reduces desire for sugar and sugar consumption. Stice. Eric.
  24. Stice E, Yokum S, Gau JM . Gymnemic acids lozenge reduces short-term consumption of high-sugar food: A placebo controlled experiment . Journal of Psychopharmacology . 31 . 11 . 1496–1502 . 2017 . 28944714 . 10.1177/0269881117728541 . 46836377 .
  25. Ogawa Y, Sekita K, Umemura T, Saito M, Ono A, Kawasaki Y, Uchida O, Matsushima Y, Inoue T, Kanno J . [Gymnema sylvestre leaf extract: a 52-week dietary toxicity study in Wistar rats] . Shokuhin Eiseigaku Zasshi. Journal of the Food Hygienic Society of Japan . 45 . 1 . 8–18 . February 2004 . 15168555 . 10.3358/shokueishi.45.8 . free .
  26. Ueno. M . vanc . 1993. The bioactivity and use of the sugar absorption inhibitor "Gymnema sylvestre". Technical Journal on Food Chemistry & Chemicals. 12. 21–26.
  27. Preuss . H.G. . Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss. . 15056124 . 10.1111/j.1462-8902.2004.00328.x . 6 . 2004 . Diabetes Obes Metab . 3 . 171–80. 36237508 .
  28. [s:The New International Encyclopædia/Gymnema]

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